CSNK1E, casein kinase 1 epsilon, 1454

N. diseases: 61; N. variants: 4
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1569077009
rs1569077009
Entrez Id: 1454;102800317
Gene Symbol: CSNK1E;TPTEP2-CSNK1E
CSNK1E;TPTEP2-CSNK1E
CUI: C3463992
Disease:
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 1 		T 0.700 CausalMutation CLINVAR
dbSNP: rs1534891
rs1534891
Entrez Id: 1454;102800317
Gene Symbol: CSNK1E;TPTEP2-CSNK1E
CSNK1E;TPTEP2-CSNK1E
CUI: C0005586
Disease:
Bipolar Disorder 		0.030 GeneticVariation BEFREE No allelic or genotypic association between SNP rs1534891 and bipolar disorder was observed. 30445897 2018
dbSNP: rs1534891
rs1534891
Entrez Id: 1454;102800317
Gene Symbol: CSNK1E;TPTEP2-CSNK1E
CSNK1E;TPTEP2-CSNK1E
CUI: C0005586
Disease:
Bipolar Disorder 		0.030 GeneticVariation BEFREE However, a 4-locus CSNK1E haplotype encompassing the rs1534891 SNP (Z-score=2.685, permuted p=0.0076) and a 3-locus haplotype in ARNTL (Z-score=3.269, permuted p=0.0011) showed a significant association with BD. 26283580 2015
dbSNP: rs1534891
rs1534891
Entrez Id: 1454;102800317
Gene Symbol: CSNK1E;TPTEP2-CSNK1E
CSNK1E;TPTEP2-CSNK1E
CUI: C0005586
Disease:
Bipolar Disorder 		0.030 GeneticVariation BEFREE A multi-locus interaction between rs6442925 in the 5' upstream of BHLHB2, rs1534891 in CSNK1E, and rs534654 near the 3' end of the CLOCK gene, however, is significantly associated with BP (P = 0.00000172). 18228528 2008
dbSNP: rs2075984
rs2075984
Entrez Id: 1454;102800317
Gene Symbol: CSNK1E;TPTEP2-CSNK1E
CSNK1E;TPTEP2-CSNK1E
CUI: C0005586
Disease:
Bipolar Disorder 		0.020 GeneticVariation BEFREE CSNK1E SNP rs2075984 seemed to play a significant role in the development of bipolar disorder in this Korean sample. 30445897 2018
dbSNP: rs2075984
rs2075984
Entrez Id: 1454;102800317
Gene Symbol: CSNK1E;TPTEP2-CSNK1E
CSNK1E;TPTEP2-CSNK1E
CUI: C0005586
Disease:
Bipolar Disorder 		0.020 GeneticVariation BEFREE None of the SNPs showed a significant association with MDD, but a SNP (rs2075984) in CSNK1E and SNP (rs6502097) in CSNK1D were associated with SCZ (P=0.0091, uncorrected) and BD (P=0.030, uncorrected), respectively. 22981886 2012
dbSNP: rs1534891
rs1534891
Entrez Id: 1454;102800317
Gene Symbol: CSNK1E;TPTEP2-CSNK1E
CSNK1E;TPTEP2-CSNK1E
CUI: C0546837
Disease:
Malignant neoplasm of esophagus 		0.010 GeneticVariation BEFREE We also found an association between the cell cycle regulation pathway and esophagus cancer (P-corrected = 1.48 × 10(-) (2)), explained by three SNPs located within or near CSNK1E gene: rs1534891 (P = 1.27 × 10(-) (4)), rs7289981 (P = 3.37 × 10(-) (3)) and rs13054361 (P = 4.09 × 10(-) (3)). 24658182 2014
dbSNP: rs1534891
rs1534891
Entrez Id: 1454;102800317
Gene Symbol: CSNK1E;TPTEP2-CSNK1E
CSNK1E;TPTEP2-CSNK1E
CUI: C0019337
Disease:
Heroin Dependence 		0.010 GeneticVariation BEFREE The results support our previous report of association of CSNK1E SNP rs1534891 with protection from heroin addiction. 25521358 2014
dbSNP: rs1997644
rs1997644
Entrez Id: 1454;102800317
Gene Symbol: CSNK1E;TPTEP2-CSNK1E
CSNK1E;TPTEP2-CSNK1E
CUI: C0019337
Disease:
Heroin Dependence 		0.010 GeneticVariation BEFREE In this study, to identify markers contributing to the genetic susceptibility of the Csnk1ε gene to heroin dependence, we examined the potential association between heroin dependence and 14 single nucleotide polymorphisms (SNPs; rs1997644, rs135764, rs867198, rs135763, rs135757, rs6001090, rs5750581, rs1534891, rs1005473, rs3890379, rs2075984, rs2075983, rs135749, and rs135745) of the Csnk1ε gene using the MassARRAY system. 24338102 2014
dbSNP: rs2075984
rs2075984
Entrez Id: 1454;102800317
Gene Symbol: CSNK1E;TPTEP2-CSNK1E
CSNK1E;TPTEP2-CSNK1E
CUI: C1269683
Disease:
Major Depressive Disorder 		0.010 GeneticVariation BEFREE None of the SNPs showed a significant association with MDD, but a SNP (rs2075984) in CSNK1E and SNP (rs6502097) in CSNK1D were associated with SCZ (P=0.0091, uncorrected) and BD (P=0.030, uncorrected), respectively. 22981886 2012
dbSNP: rs2075984
rs2075984
Entrez Id: 1454;102800317
Gene Symbol: CSNK1E;TPTEP2-CSNK1E
CSNK1E;TPTEP2-CSNK1E
CUI: C0036341
Disease:
Schizophrenia 		0.010 GeneticVariation BEFREE None of the SNPs showed a significant association with MDD, but a SNP (rs2075984) in CSNK1E and SNP (rs6502097) in CSNK1D were associated with SCZ (P=0.0091, uncorrected) and BD (P=0.030, uncorrected), respectively. 22981886 2012
dbSNP: rs1534891
rs1534891
Entrez Id: 1454;102800317
Gene Symbol: CSNK1E;TPTEP2-CSNK1E
CSNK1E;TPTEP2-CSNK1E
CUI: C0600139
Disease:
Prostate carcinoma 		0.010 GeneticVariation BEFREE Our results showed that at least one SNP in nine core circadian genes (rs885747 and rs2289591 in PER1; rs7602358 in PER2; rs1012477 in PER3; rs1534891 in CSNK1E; rs12315175 in CRY1; rs2292912 in CRY2; rs7950226 in ARNTL; rs11133373 in CLOCK; and rs1369481, rs895521, and rs17024926 in NPAS2) was significantly associated with susceptibility to prostate cancer (either overall risk or risk of aggressive disease), and the risk estimate for four SNPs in three genes (rs885747 and rs2289591 in PER1, rs1012477 in PER3, and rs11133373 in CLOCK) varied by disease aggressiveness. 19934327 2009
dbSNP: rs1534891
rs1534891
Entrez Id: 1454;102800317
Gene Symbol: CSNK1E;TPTEP2-CSNK1E
CSNK1E;TPTEP2-CSNK1E
CUI: C0376358
Disease:
Malignant neoplasm of prostate 		0.010 GeneticVariation BEFREE Our results showed that at least one SNP in nine core circadian genes (rs885747 and rs2289591 in PER1; rs7602358 in PER2; rs1012477 in PER3; rs1534891 in CSNK1E; rs12315175 in CRY1; rs2292912 in CRY2; rs7950226 in ARNTL; rs11133373 in CLOCK; and rs1369481, rs895521, and rs17024926 in NPAS2) was significantly associated with susceptibility to prostate cancer (either overall risk or risk of aggressive disease), and the risk estimate for four SNPs in three genes (rs885747 and rs2289591 in PER1, rs1012477 in PER3, and rs11133373 in CLOCK) varied by disease aggressiveness. 19934327 2009