|
Bipolar Disorder
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
TIMELESS rs4630333 and CSNK1E rs135745 were significantly associated with both major depressive disorder and bipolar disorder.
|
31323592 |
2019 |
|
Bipolar Disorder
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
CSNK1E SNP rs2075984 seemed to play a significant role in the development of bipolar disorder in this Korean sample.
|
30445897 |
2018 |
|
Bipolar Disorder
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
However, a 4-locus CSNK1E haplotype encompassing the rs1534891 SNP (Z-score=2.685, permuted p=0.0076) and a 3-locus haplotype in ARNTL (Z-score=3.269, permuted p=0.0011) showed a significant association with BD.
|
26283580 |
2015 |
|
Bipolar Disorder
|
0.360 |
Biomarker
|
disease |
PSYGENET |
None of the SNPs showed a significant association with MDD, but a SNP (rs2075984) in CSNK1E and SNP (rs6502097) in CSNK1D were associated with SCZ (P=0.0091, uncorrected) and BD (P=0.030, uncorrected), respectively.
|
22981886 |
2012 |
|
Bipolar Disorder
|
0.360 |
Biomarker
|
disease |
PSYGENET |
An inhibitor of casein kinase 1 ε/δ partially normalizes the manic-like behaviors of the ClockΔ19 mouse.
|
22743604 |
2012 |
|
Bipolar Disorder
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
None of the SNPs showed a significant association with MDD, but a SNP (rs2075984) in CSNK1E and SNP (rs6502097) in CSNK1D were associated with SCZ (P=0.0091, uncorrected) and BD (P=0.030, uncorrected), respectively.
|
22981886 |
2012 |
|
Bipolar Disorder
|
0.360 |
Biomarker
|
disease |
PSYGENET |
We examined 209 single-nucleotide polymorphisms (SNPs) covering 19 circadian genes (ADCYAP1, ARNTL, ARNTL2, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1E, DBP, NPAS2, NR1D1, PER1, PER2, PER3, RORA, TIMELESS, VIP, and VIPR2) in a sample of 534 MD patients (335 with unipolar major mood depression (MDD) and 199 with bipolar disorder (BD)) and 440 community-based screened controls.
|
20072116 |
2010 |
|
Bipolar Disorder
|
0.360 |
Biomarker
|
disease |
PSYGENET |
A multi-locus interaction between rs6442925 in the 5' upstream of BHLHB2, rs1534891 in CSNK1E, and rs534654 near the 3' end of the CLOCK gene, however, is significantly associated with BP (P = 0.00000172).
|
18228528 |
2008 |
|
Bipolar Disorder
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
A multi-locus interaction between rs6442925 in the 5' upstream of BHLHB2, rs1534891 in CSNK1E, and rs534654 near the 3' end of the CLOCK gene, however, is significantly associated with BP (P = 0.00000172).
|
18228528 |
2008 |
|
Bipolar Disorder
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
Polymorphism on the CKIepsilon binding region of hper2 gene which was previously reported, is unlikely to play an important role in the development of bipolar disorder.
|
12565145 |
2003 |
|
Bipolar Disorder
|
0.360 |
Biomarker
|
disease |
PSYGENET |
Polymorphism on the CKIepsilon binding region of hper2 gene which was previously reported, is unlikely to play an important role in the development of bipolar disorder.
|
12565145 |
2003 |
|
Schizophrenia
|
0.320 |
Biomarker
|
disease |
PSYGENET |
None of the SNPs showed a significant association with MDD, but a SNP (rs2075984) in CSNK1E and SNP (rs6502097) in CSNK1D were associated with SCZ (P=0.0091, uncorrected) and BD (P=0.030, uncorrected), respectively.
|
22981886 |
2012 |
|
Schizophrenia
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
None of the SNPs showed a significant association with MDD, but a SNP (rs2075984) in CSNK1E and SNP (rs6502097) in CSNK1D were associated with SCZ (P=0.0091, uncorrected) and BD (P=0.030, uncorrected), respectively.
|
22981886 |
2012 |
|
Schizophrenia
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Association between a casein kinase 1 ε gene polymorphism and schizophrenia in a Chinese Han population.
|
22367616 |
2012 |
|
Schizophrenia
|
0.320 |
Biomarker
|
disease |
PSYGENET |
Association between a casein kinase 1 ε gene polymorphism and schizophrenia in a Chinese Han population.
|
22367616 |
2012 |
|
Psychotic Disorders
|
0.310 |
GeneticVariation
|
group |
BEFREE |
The present findings suggest that having a genetic variant of the CSNK1E gene did not affect susceptibility to methamphetamine dependence or psychosis, at least in a Japanese population.
|
18991847 |
2008 |
|
Nonorganic psychosis
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
The present findings suggest that having a genetic variant of the CSNK1E gene did not affect susceptibility to methamphetamine dependence or psychosis, at least in a Japanese population.
|
18991847 |
2008 |
|
Adenocarcinoma of lung (disorder)
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 1
|
0.100 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Malignant neoplasm of breast
|
0.060 |
Biomarker
|
disease |
BEFREE |
Out of 17 genes investigated, 15 were found to be significantly associated with the risk of cancer: four genes were shared by all three malignancies (ARNTL, CLOCK, RORA and RORB), two by breast and lung cancer (CRY1 and CRY2) and three by prostate and lung cancer (NPAS2, NR1D1 and PER3), whereas four genes were specific for lung cancer (ARNTL2, CSNK1E, NR1D2 and PER2) and two for breast cancer (PER1, RORC).
|
29455641 |
2018 |
|
Breast Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
Out of 17 genes investigated, 15 were found to be significantly associated with the risk of cancer: four genes were shared by all three malignancies (ARNTL, CLOCK, RORA and RORB), two by breast and lung cancer (CRY1 and CRY2) and three by prostate and lung cancer (NPAS2, NR1D1 and PER3), whereas four genes were specific for lung cancer (ARNTL2, CSNK1E, NR1D2 and PER2) and two for breast cancer (PER1, RORC).
|
29455641 |
2018 |
|
Malignant neoplasm of breast
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Multivariate analysis found high expression of CK1ε to be associated with a statistically significant higher disease-free survival (DFS) in BC patients with wild-type p53 (Hazard ratio [HR] = 0.33; 95% CI, 0.12-0.91; P = 0.018) or poor histological differentiation ([HR] = 0.34; 95% CI, 0.12-0.94; P = 0.039) or in those without adjuvant chemotherapy ([HR] = 0.11; 95% CI, 0.01-0.97; P = 0.006).
|
26327509 |
2015 |
|
Breast Carcinoma
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Multivariate analysis found high expression of CK1ε to be associated with a statistically significant higher disease-free survival (DFS) in BC patients with wild-type p53 (Hazard ratio [HR] = 0.33; 95% CI, 0.12-0.91; P = 0.018) or poor histological differentiation ([HR] = 0.34; 95% CI, 0.12-0.94; P = 0.039) or in those without adjuvant chemotherapy ([HR] = 0.11; 95% CI, 0.01-0.97; P = 0.006).
|
26327509 |
2015 |
|
Malignant neoplasm of breast
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
In women with three consecutive night shifts, a reduced risk of breast cancer was associated with carriage of variant alleles of SNPs in CLOCK (rs3749474), BMAL1 (rs2278749), BMAL2 (rs2306074), CSNK1E (rs5757037), NPAS2 (rs17024926), ROR-b (rs3903529, rs3750420), MTNR1A (rs131113549) and PER3 (rs1012477).
|
23822714 |
2013 |
|
Breast Carcinoma
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
In women with three consecutive night shifts, a reduced risk of breast cancer was associated with carriage of variant alleles of SNPs in CLOCK (rs3749474), BMAL1 (rs2278749), BMAL2 (rs2306074), CSNK1E (rs5757037), NPAS2 (rs17024926), ROR-b (rs3903529, rs3750420), MTNR1A (rs131113549) and PER3 (rs1012477).
|
23822714 |
2013 |