DGKH, diacylglycerol kinase eta, 160851

N. diseases: 39; N. variants: 24
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.500 GeneticVariation disease BEFREE The second aim was to investigate possible interaction between the previously published common risk gene variants of ADHD in the ADGRL3 (=LPHN3) gene (rs2305339, rs1397548, rs734644, rs1397547, rs2271338, rs6551665, and rs2345039) and shared risk gene variants of aADHD and BD in the DGKH gene (DGKH rs994856/rs9525580/rs9525584 GAT haplotype) and pre-, peri-, and postnatal risk factors in comparison to a healthy control group. 30758784 2019
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.500 GeneticVariation disease BEFREE Generation of human induced pluripotent stem cell lines (hiPSC) from one bipolar disorder patient carrier of a DGKH risk haplotype and one non-risk-variant-carrier bipolar disorder patient. 30266033 2018
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.500 GeneticVariation disease BEFREE The aim of the present study was to examine the relation of the DGKH genotype with broad dimensions of personality, to obtain further evidence for its implication in the etiology of bipolar disorder. 29936393 2018
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.500 GeneticVariation disease BEFREE In this proof-of-concept study we isolated mRNA from peripheral blood and fibroblasts of heterozygote DGKH risk variants carriers (risk haplotype rs994856/rs9525580/rs9525584 GAT) with bipolar disorder and non-risk variant carriers with and without bipolar disorder. 27016658 2016
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.500 Biomarker disease BEFREE Interestingly DGKH has previously demonstrated genome-wide significant association with bipolar disorder as well as evidence of association to other mental disorders. 27255576 2016
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.500 Biomarker disease PSYGENET These findings add to the notion of a role of DGKH in the pathogenesis of BD. 24958494 2015
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.500 Biomarker disease BEFREE These findings add to the notion of a role of DGKH in the pathogenesis of BD. 24958494 2015
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.500 Biomarker disease PSYGENET In addition to pathway enrichment, the collective network approach elevates the importance of ANK3, DGKH and ODZ4 for BD susceptibility in the WTCCC GWAS, despite their weak single-locus effect in the data. 22892719 2012
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.500 Biomarker disease PSYGENET Individuals at high familial risk for BD homozygous for the DGKH risk haplotype demonstrated relatively greater activation (poor suppression) of these regions during the task vs the low-risk haplotype subjects. 22048461 2012
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.500 GeneticVariation disease BEFREE Individuals at high familial risk for BD homozygous for the DGKH risk haplotype demonstrated relatively greater activation (poor suppression) of these regions during the task vs the low-risk haplotype subjects. 22048461 2012
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.500 Biomarker disease BEFREE In addition to pathway enrichment, the collective network approach elevates the importance of ANK3, DGKH and ODZ4 for BD susceptibility in the WTCCC GWAS, despite their weak single-locus effect in the data. 22892719 2012
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.500 Biomarker disease PSYGENET A modest association was also detected for SNP rs1012053 (GWAS P = 4.50 × 10(-2)) in DGKH, which has already been reported as the most significant variant in a previous genome-wide scan on bipolar disorder. 21771265 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.500 Biomarker disease BEFREE Although the association was not strong, the result of this study would support the association between DGKH and BD. 21507135 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.500 Biomarker disease BEFREE Cross-disorder analysis of bipolar risk genes: further evidence of DGKH as a risk gene for bipolar disorder, but also unipolar depression and adult ADHD. 21654738 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.500 Biomarker disease PSYGENET Cross-disorder analysis of bipolar risk genes: further evidence of DGKH as a risk gene for bipolar disorder, but also unipolar depression and adult ADHD. 21654738 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.500 Biomarker disease BEFREE No association between DGKH and bipolar disorder in a Scandinavian case-control sample. 19478689 2009
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.500 Biomarker disease BEFREE Nevertheless, genomewide association analysis, which has successfully identified susceptibility genes for a variety of complex disorders, has begun to implicate specific genes for bipolar disorder (DGKH, CACNA1C, ANK3). 19358880 2009
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.500 GeneticVariation disease GWASDB A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder. 17486107 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.500 Biomarker disease BEFREE A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder. 17486107 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.500 GeneticVariation disease GWASCAT A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder. 17486107 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.500 Biomarker disease LHGDN A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder. 17486107 2008
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.320 GeneticVariation disease BEFREE In a recent study, we were able to identify a risk haplotype for BPD, as well as for unipolar depression and adult attention-deficit/hyperactivity disorder (ADHD), within the DGKH gene. 27085324 2017
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.320 Biomarker disease PSYGENET Cross-disorder analysis of bipolar risk genes: further evidence of DGKH as a risk gene for bipolar disorder, but also unipolar depression and adult ADHD. 21654738 2011
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.320 Biomarker disease BEFREE Cross-disorder analysis of bipolar risk genes: further evidence of DGKH as a risk gene for bipolar disorder, but also unipolar depression and adult ADHD. 21654738 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.310 GeneticVariation disease BEFREE Influence of DGKH variants on amygdala volume in patients with bipolar affective disorder and schizophrenia. 24958494 2015