DGKH, diacylglycerol kinase eta, 160851

N. diseases: 39; N. variants: 24
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4142110
rs4142110
Entrez Id: 160851
Gene Symbol: DGKH
DGKH
CUI: C0392525
Disease:
Nephrolithiasis 		0.830 GeneticVariation BEFREE We selected single-nucleotide polymorphism (SNPs) including rs12654812 and rs11746443 from 5q32.3; rs12669187 and rs1000597 from 7q14.3; rs7981733, rs4142110 and rs17646069 from 13q14.1 and rs4293393 from 16p12.3 which were previously reported to be associated with nephrolithiasis. 28361944 2017
dbSNP: rs4142110
rs4142110
Entrez Id: 160851
Gene Symbol: DGKH
DGKH
CUI: C0392525
Disease:
Nephrolithiasis 		0.830 GeneticVariation BEFREE We selected seven single-nucleotide polymorphisms (SNPs): rs12654812 and rs11746443 from 5q35.3 (RGS14-SLC34A1-PFN3-F12); rs12669187 and rs1000597 from 7p14.3 (INMT-FAM188B-AQP1); and rs7981733, rs1170155, and rs4142110 from 13q14.1 (DGKH (diacylglycerol kinase)), which were previously reported to be significantly associated with nephrolithiasis. rs12654812, rs12669187 and rs7981733 were significantly associated with nephrolithiasis after Bonferroni's correction (P=3.12 × 10(-3), odds ratio (OR)=1.43; P=6.40 × 10(-3), OR=1.57; and P=5.00 × 10(-3), OR=1.41, respectively). 23719187 2013
dbSNP: rs4142110
rs4142110
Entrez Id: 160851
Gene Symbol: DGKH
DGKH
CUI: C0392525
Disease:
Nephrolithiasis 		0.830 GeneticVariation GWASCAT Here we found three novel loci for nephrolithiasis: RGS14-SLC34A1-PFN3-F12 on 5q35.3 (rs11746443; P = 8.51×10⁻¹², odds ratio (OR) = 1.19), INMT-FAM188B-AQP1 on 7p14.3 (rs1000597; P = 2.16×10⁻¹⁴, OR = 1.22), and DGKH on 13q14.1 (rs4142110; P = 4.62×10⁻⁹, OR = 1.14). 22396660 2012
dbSNP: rs4142110
rs4142110
Entrez Id: 160851
Gene Symbol: DGKH
DGKH
CUI: C0392525
Disease:
Nephrolithiasis 		0.830 GeneticVariation BEFREE Here we found three novel loci for nephrolithiasis: RGS14-SLC34A1-PFN3-F12 on 5q35.3 (rs11746443; P = 8.51×10⁻¹², odds ratio (OR) = 1.19), INMT-FAM188B-AQP1 on 7p14.3 (rs1000597; P = 2.16×10⁻¹⁴, OR = 1.22), and DGKH on 13q14.1 (rs4142110; P = 4.62×10⁻⁹, OR = 1.14). 22396660 2012
dbSNP: rs4142110
rs4142110
Entrez Id: 160851
Gene Symbol: DGKH
DGKH
CUI: C0392525
Disease:
Nephrolithiasis 		0.830 GeneticVariation GWASDB Here we found three novel loci for nephrolithiasis: RGS14-SLC34A1-PFN3-F12 on 5q35.3 (rs11746443; P = 8.51×10⁻¹², odds ratio (OR) = 1.19), INMT-FAM188B-AQP1 on 7p14.3 (rs1000597; P = 2.16×10⁻¹⁴, OR = 1.22), and DGKH on 13q14.1 (rs4142110; P = 4.62×10⁻⁹, OR = 1.14). 22396660 2012
dbSNP: rs1012053
rs1012053
Entrez Id: 160851
Gene Symbol: DGKH
DGKH
CUI: C0005586
Disease:
Bipolar Disorder 		A 0.800 GeneticVariation GWASDB A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder. 17486107 2008
dbSNP: rs1012053
rs1012053
Entrez Id: 160851
Gene Symbol: DGKH
DGKH
CUI: C0005586
Disease:
Bipolar Disorder 		A 0.800 GeneticVariation GWASCAT A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder. 17486107 2008
dbSNP: rs7981733
rs7981733
Entrez Id: 160851
Gene Symbol: DGKH
DGKH
CUI: C0392525
Disease:
Nephrolithiasis 		0.710 GeneticVariation BEFREE We selected seven single-nucleotide polymorphisms (SNPs): rs12654812 and rs11746443 from 5q35.3 (RGS14-SLC34A1-PFN3-F12); rs12669187 and rs1000597 from 7p14.3 (INMT-FAM188B-AQP1); and rs7981733, rs1170155, and rs4142110 from 13q14.1 (DGKH (diacylglycerol kinase)), which were previously reported to be significantly associated with nephrolithiasis. rs12654812, rs12669187 and rs7981733 were significantly associated with nephrolithiasis after Bonferroni's correction (P=3.12 × 10(-3), odds ratio (OR)=1.43; P=6.40 × 10(-3), OR=1.57; and P=5.00 × 10(-3), OR=1.41, respectively). 23719187 2013
dbSNP: rs7981733
rs7981733
Entrez Id: 160851
Gene Symbol: DGKH
DGKH
CUI: C0392525
Disease:
Nephrolithiasis 		0.710 GeneticVariation GWASDB A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1. 22396660 2012
dbSNP: rs34445998
rs34445998
Entrez Id: 160851
Gene Symbol: DGKH
DGKH
CUI: C0017654
Disease:
Glomerular Filtration Rate 		C 0.700 GeneticVariation GWASCAT Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies. 30604766 2019
dbSNP: rs347413
rs347413
Entrez Id: 160851
Gene Symbol: DGKH
DGKH
CUI: C0017654
Disease:
Glomerular Filtration Rate 		G 0.700 GeneticVariation GWASCAT Sex-specific and pleiotropic effects underlying kidney function identified from GWAS meta-analysis. 31015462 2019
dbSNP: rs7328064
rs7328064
Entrez Id: 160851
Gene Symbol: DGKH
DGKH
CUI: C0451641
Disease:
Urolithiasis 		C 0.700 GeneticVariation GWASCAT Novel Risk Loci Identified in a Genome-Wide Association Study of Urolithiasis in a Japanese Population. 30975718 2019
dbSNP: rs9533031
rs9533031
Entrez Id: 160851
Gene Symbol: DGKH
DGKH
CUI: C0005890
Disease:
Body Height 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs9590675
rs9590675
Entrez Id: 160851
Gene Symbol: DGKH
DGKH
CUI: C0017654
Disease:
Glomerular Filtration Rate 		T 0.700 GeneticVariation GWASCAT A catalog of genetic loci associated with kidney function from analyses of a million individuals. 31152163 2019
dbSNP: rs9594674
rs9594674
Entrez Id: 160851
Gene Symbol: DGKH
DGKH
CUI: C0200638
Disease:
Eosinophil count procedure 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs12583267
rs12583267
Entrez Id: 160851
Gene Symbol: DGKH
DGKH
CUI: C0005845
Disease:
Blood urea nitrogen measurement 		0.700 GeneticVariation GWASCAT Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases. 29403010 2018
dbSNP: rs67332916
rs67332916
Entrez Id: 160851
Gene Symbol: DGKH
DGKH
CUI: C0017654
Disease:
Glomerular Filtration Rate 		0.700 GeneticVariation GWASCAT Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases. 29403010 2018
dbSNP: rs67332916
rs67332916
Entrez Id: 160851
Gene Symbol: DGKH
DGKH
CUI: C0201976
Disease:
Creatinine measurement, serum (procedure) 		0.700 GeneticVariation GWASCAT Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases. 29403010 2018
dbSNP: rs73187288
rs73187288
Entrez Id: 160851
Gene Symbol: DGKH
DGKH
CUI: C0871470
Disease:
Systolic Pressure 		A 0.700 GeneticVariation GWASCAT Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. 30224653 2018
dbSNP: rs1170109
rs1170109
Entrez Id: 160851
Gene Symbol: DGKH
DGKH
CUI: C0201968
Disease:
Cortisol Measurement 		T 0.700 GeneticVariation GWASCAT The low single nucleotide polymorphism heritability of plasma and saliva cortisol levels. 28843169 2017
dbSNP: rs347412
rs347412
Entrez Id: 160851
Gene Symbol: DGKH
DGKH
CUI: C0004096
Disease:
Asthma 		A 0.700 GeneticVariation GWASCAT Genome-wide interrogation of longitudinal FEV1 in children with asthma. 25221879 2014
dbSNP: rs347412
rs347412
Entrez Id: 160851
Gene Symbol: DGKH
DGKH
CUI: C0035227
Disease:
Respiratory Function Tests 		A 0.700 GeneticVariation GWASCAT Genome-wide interrogation of longitudinal FEV1 in children with asthma. 25221879 2014
dbSNP: rs347412
rs347412
Entrez Id: 160851
Gene Symbol: DGKH
DGKH
CUI: C0016529
Disease:
Forced expiratory volume function 		A 0.700 GeneticVariation GWASCAT Genome-wide interrogation of longitudinal FEV1 in children with asthma. 25221879 2014
dbSNP: rs4142110
rs4142110
Entrez Id: 160851
Gene Symbol: DGKH
DGKH
CUI: C0156257
Disease:
Calculus of kidney and ureter 		0.700 GeneticVariation GWASCAT A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1. 22396660 2012
dbSNP: rs912875
rs912875
Entrez Id: 160851
Gene Symbol: DGKH
DGKH
CUI: C0392525
Disease:
Nephrolithiasis 		0.700 GeneticVariation GWASDB A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1. 22396660 2012