|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated the association of variants around these genes with schizophrenia and schizoaffective disorder in 104 small nuclear families using the Sib-Transmission Disequilibrium Test (TDT-STDT).
|
20950212 |
2011 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No evidence was obtained for preferential transmission of the Cys23Ser 5HT2C alleles in schizophrenia in either of the two main ethnic groups examined (German and Palestinian Arab) or in the combined cohort (TDT chi-square = 0.00, NS).
|
11353441 |
2001 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The TDT analysis demonstrated that of the nine SNPs, three were associated with schizophrenia, including rs1009382 (P = 0.00047), rs204887 (P = 0.007), and rs8283 (P = 0.015).
|
14755442 |
2004 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the family-based sample, a significant genetic association was found between schizophrenia and one of the four single nucleotide polymorphisms (SNPs) tested: an intron 7 SNP (transmission disequilibrium test [TDT] chi(2) = 5.898; df = 1; p =.015, family-based association test [FBAT] z = 2.280, p =.023).
|
15219469 |
2004 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently, the sulfotransferase-4A1 (Sult4A1) locus within chromosome 22q13 was reported to be linked to schizophrenia in a family TDT study.
|
18823757 |
2008 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Using a TDT approach, we showed that the G allele of the -1438A/G polymorphism of the gene coding for the 5-HT2A receptor was associated to schizophrenia with good response to conventional antipsychotics, although this conclusion is based on 88 informative patients only.
|
18513383 |
2008 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Haplotype TDT was statistically significant (X(2)=5.14, df=1, P=0.023), with the rs6603272(T)-rs6645249(G) haplotype significantly associated with schizophrenia (OR=1.66; 95% CI=1.08-2.55).
|
19281803 |
2009 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The NOTCH4 gene was recently reported to be associated with schizophrenia based on TDT analysis of 80 British trios.
|
11381258 |
2001 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The TDT for allelic association demonstrated that, in male, a weak association was detected in SNP rs475827 with p=0.0294, suggesting that the genetic polymorphisms within PLP1 in male are likely to confer an increased susceptibility to schizophrenia in the Chinese population.
|
15694262 |
2005 |
|
Attention deficit hyperactivity disorder
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
When haplotype TDT analysis of HTR4 was performed, we further found that the C/G haplotype of the 83097 C>T and 83198 A>G polymorphisms (chi(2)=8.783, P=0.003) and the C/G/C haplotype of these and the -36 C>T polymorphism (chi(2)=5.762, P=0.016) were under-transmitted to probands with ADHD.
|
16563621 |
2006 |
|
Attention deficit hyperactivity disorder
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
TDT analysis of the data yielded two polymorphisms that were significantly associated with ADHD (rs2770112-Transmitted: 71 Not Transmitted; 48; rs12861247-Transmitted: 43 Not Transmitted: 21), located towards the 5' end of the gene (P < 0.05).
|
18937300 |
2008 |
|
Attention deficit hyperactivity disorder
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
However TDT analysis showed no preferential transmission of allele 7 to ADHD probands.
|
11032386 |
2000 |
|
Attention deficit hyperactivity disorder
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Using case control analysis and then the TDT, no association was found between these two MAOA polymorphisms and ADHD.
|
12497620 |
2003 |
|
Attention deficit hyperactivity disorder
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest a significant association of ADHD with SNP rs498793 (case-control p = .004, odds ratio [OR] 1.6, 95% confidence interval [CI] 1.15-2.23; transmission disequilibrium test [TDT] p = .014, OR 1.69) in the fatty acid desaturase 2 (FADS2) gene.
|
16893529 |
2006 |
|
Autistic Disorder
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
In TDT analysis, rs69510130 (p=0.027) showed nominal associations with autism; modest haplotype association was also observed.
|
21118708 |
2011 |
|
Autistic Disorder
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
However, when a meta-analysis of all the available TDT data, inclusive of the present study is carried out, we observed a significant preferential transmission of S-allele from parents to the affected offspring (chi2 = 7.51, P = 0.006) indicating an association of 5-HTTLPR with autism.
|
16674932 |
2006 |
|
Autistic Disorder
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
As predicted, Caucasian-American and not Italian families display a significant association between autism and PON1 variants less active in vitro on the OP diazinon (R192), according to case-control contrasts (Q192R: chi2=6.33, 1 df, P<0.025), transmission/disequilibrium tests (Q192R: TDT chi2=5.26, 1 df, P<0.025), family-based association tests (Q192R and L55M: FBAT Z=2.291 and 2.435 respectively, P<0.025), and haplotype-based association tests (L55/R192: HBAT Z=2.430, P<0.025).
|
16027737 |
2005 |
|
Autistic Disorder
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
In single SNP TDT analysis, C270T showed preferential transmission of the T allele compared to the C allele (TDT p < 0.001) in autism.
|
20201430 |
2009 |
|
Autistic Disorder
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
TPH2 alleles and haplotypes are not significantly associated in our sample with autism (rs4570625: TDT P = 0.27, and FBAT P = 0.35; rs4565946: TDT P = 0.45, and FBAT P = 0.55; haplotype P = 0.84), with any endophenotype, or with the presence/absence of prominent repetitive and stereotyped behaviors (motor stereotypies: P = 0.81 and 0.84, verbal stereotypies: P = 0.38 and 0.73 for rs4570625 and rs4565946, respectively).
|
17346350 |
2007 |
|
Autistic Disorder
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Therefore in the present study, we have performed genetic analysis of three markers of GluR6 (SNP1: rs2227281, SNP2: rs2227283, SNP3: rs2235076) for possible association with autism through population, and family-based (TDT and HHRR) approaches.
|
17712621 |
2007 |
|
Gilles de la Tourette syndrome
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Marker D7S522 showed a biased transmission of alleles from heterozygote parents to their TS offsprings (allele-wise TDT chi(2) = 12.61, 4 df, P = 0.013, genotype-wise TDT chi(2) = 15.49, 7 df, P = 0.030).
|
15103711 |
2004 |
|
Anorexia Nervosa
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Using HHRR and TDT approaches, we found that both polymorphisms were preferentially transmitted to AN offspring (TDT yielded chi(2)=5.01, p=0.025 for NR2B 5073G alleles and chi(2)=11.75, p<0.001 for SK3 L alleles including >19 repeats).
|
16157352 |
2007 |
|
Anorexia Nervosa
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We then stratified the MAOA-uVNTR TDT data according to the (a) NETpPR genotype of the AN-R females, and (b) NETpPR allele transmitted from NETpPR-S4/L4 heterozygous mothers.
|
14508509 |
2003 |
|
Rheumatoid Arthritis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The (CCTTT)(n)locus showed a trend for RA association in the case-control study, however, stratification data by Class II status did not yield significant effect and overall, the family study showed no significant association nor linkage for any of the markers under study using TDT and non-parametric linkage respectively.
|
12140750 |
2002 |
|
Coronary heart disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The results of TDT analysis showed that no allele transmission disequilibrium existed in CHD nuclear families.
|
17319270 |
2006 |