|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated the association of variants around these genes with schizophrenia and schizoaffective disorder in 104 small nuclear families using the Sib-Transmission Disequilibrium Test (TDT-STDT).
|
20950212 |
2011 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Haplotype TDT was statistically significant (X(2)=5.14, df=1, P=0.023), with the rs6603272(T)-rs6645249(G) haplotype significantly associated with schizophrenia (OR=1.66; 95% CI=1.08-2.55).
|
19281803 |
2009 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently, the sulfotransferase-4A1 (Sult4A1) locus within chromosome 22q13 was reported to be linked to schizophrenia in a family TDT study.
|
18823757 |
2008 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Using a TDT approach, we showed that the G allele of the -1438A/G polymorphism of the gene coding for the 5-HT2A receptor was associated to schizophrenia with good response to conventional antipsychotics, although this conclusion is based on 88 informative patients only.
|
18513383 |
2008 |
|
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Case-control and TDT analyses were performed to detect association of DPYSL2 with schizophrenia.
|
16321170 |
2006 |
|
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
A significant genetic association with schizophrenia was found for the 14-3-3zeta isoform in a subset of nuclear families of British ancestry (TDT: chi(2)=7.2; df=1; p=0.0073), in the case-control sample overall (p=0.011), and in a subset of the case-control sample.
|
16054338 |
2005 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The TDT for allelic association demonstrated that, in male, a weak association was detected in SNP rs475827 with p=0.0294, suggesting that the genetic polymorphisms within PLP1 in male are likely to confer an increased susceptibility to schizophrenia in the Chinese population.
|
15694262 |
2005 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The TDT analysis demonstrated that of the nine SNPs, three were associated with schizophrenia, including rs1009382 (P = 0.00047), rs204887 (P = 0.007), and rs8283 (P = 0.015).
|
14755442 |
2004 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the family-based sample, a significant genetic association was found between schizophrenia and one of the four single nucleotide polymorphisms (SNPs) tested: an intron 7 SNP (transmission disequilibrium test [TDT] chi(2) = 5.898; df = 1; p =.015, family-based association test [FBAT] z = 2.280, p =.023).
|
15219469 |
2004 |
|
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
TDT analysis of D22S944 genotyped in a further 278 cases of schizophrenia and their parents failed to find any overall allele-wise significant transmission disequilibrium (chi(2) = 18.3, P = 0.17).
|
12476324 |
2002 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No evidence was obtained for preferential transmission of the Cys23Ser 5HT2C alleles in schizophrenia in either of the two main ethnic groups examined (German and Palestinian Arab) or in the combined cohort (TDT chi-square = 0.00, NS).
|
11353441 |
2001 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The NOTCH4 gene was recently reported to be associated with schizophrenia based on TDT analysis of 80 British trios.
|
11381258 |
2001 |
|
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Results of a multiallelic transmission/disequilibrium test (TDT(max) = 3.00; P = 0.55) challenged the possibility that D22S280 alleles appear with DSM-IV schizophrenia more frequently than expected.
|
10898920 |
2000 |
|
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Additional allelic association and TDT studies of 4p markers in bipolar disorder and in schizophrenia might be able to narrow the focus of the 4p investigations.
|
9686426 |
1998 |
|
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Multiallelic TDT procedure showed no association of individual CAG repeats to schizophrenia.
|
9858366 |
1998 |
|
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present study we observed this association in a sample of 63 parent/offspring trios where the proband received a diagnosis of DSM-III-R schizophrenia using TDT analysis (chi2 = 6.26, P= 0.006, chi2 = 9.00, P=0.001 when one affected offspring was selected at random from each family, suggesting that the results are due to association rather than linkage).
|
9491812 |
1998 |
|
Attention deficit hyperactivity disorder
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
TDT analysis of the data yielded two polymorphisms that were significantly associated with ADHD (rs2770112-Transmitted: 71 Not Transmitted; 48; rs12861247-Transmitted: 43 Not Transmitted: 21), located towards the 5' end of the gene (P < 0.05).
|
18937300 |
2008 |
|
Attention deficit hyperactivity disorder
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
When haplotype TDT analysis of HTR4 was performed, we further found that the C/G haplotype of the 83097 C>T and 83198 A>G polymorphisms (chi(2)=8.783, P=0.003) and the C/G/C haplotype of these and the -36 C>T polymorphism (chi(2)=5.762, P=0.016) were under-transmitted to probands with ADHD.
|
16563621 |
2006 |
|
Attention deficit hyperactivity disorder
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest a significant association of ADHD with SNP rs498793 (case-control p = .004, odds ratio [OR] 1.6, 95% confidence interval [CI] 1.15-2.23; transmission disequilibrium test [TDT] p = .014, OR 1.69) in the fatty acid desaturase 2 (FADS2) gene.
|
16893529 |
2006 |
|
Attention deficit hyperactivity disorder
|
0.080 |
Biomarker
|
disease |
BEFREE |
The negative TDT finding between DAT1 and DRD4 VNTR polymorphisms and ADHD should be interpreted with caution; partly due to lack of power caused by low heterozygosity in the study population.
|
16165273 |
2005 |
|
Attention deficit hyperactivity disorder
|
0.080 |
Biomarker
|
disease |
BEFREE |
This association is particularly pronounced among male ADHD probands without any comorbidity (50 trios, HHRR: chi(2) = 5.128, P = 0.024, df = 1; TDT: chi(2) = 4.558, P = 0.033, df = 1), especially the ADHD-I subtype (32 trios, HHRR: chi(2) = 5.792, P = 0.016, df = 1; TDT: chi(2) = 5.333, P = 0.021, df = 1).
|
12627475 |
2003 |
|
Attention deficit hyperactivity disorder
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Using case control analysis and then the TDT, no association was found between these two MAOA polymorphisms and ADHD.
|
12497620 |
2003 |
|
Attention deficit hyperactivity disorder
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
However TDT analysis showed no preferential transmission of allele 7 to ADHD probands.
|
11032386 |
2000 |
|
Attention deficit hyperactivity disorder
|
0.080 |
Biomarker
|
disease |
BEFREE |
A categorical TDT yielded no significant findings, but the number of transmissions was small, especially for ADHD-inattentive type.
|
9774775 |
1998 |
|
Autistic Disorder
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
In TDT analysis, rs69510130 (p=0.027) showed nominal associations with autism; modest haplotype association was also observed.
|
21118708 |
2011 |