|
Abnormal behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These results allow assessment of mechanisms for zebrafish abnormal behavior in response to TDT exposure, and are useful for early intervention and gene therapy of contaminant-induced diseases.
|
29874755 |
2018 |
|
Acute lymphocytic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Southern blot analyses revealed no differences in the gene structure of the promoter region of TdT genes between this ATL case and TdT-positive lymphoblastic leukemia cells.
|
1954350 |
1991 |
|
Adult Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We have isolated nearly full-length cDNA clones of terminal deoxynucleotidyltransferase (TdT) from calf thymus and mouse lymphoma cDNA libraries.
|
3755527 |
1986 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The activation of TdT gene in ATL may be mediated by other trans-acting factors.
|
1954350 |
1991 |
|
Agitation
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
All adult behavioral tests demonstrated that chronic TDT exposure (0.14 mg/L) led to hyperactivity and restlessness in adult zebrafish.
|
29874755 |
2018 |
|
Alzheimer's Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
S-TDT analysis between the BCHE-K variant and AD was also not significant (P = 0.52).
|
10430518 |
1999 |
|
Anorexia Nervosa
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Using HHRR and TDT approaches, we found that both polymorphisms were preferentially transmitted to AN offspring (TDT yielded chi(2)=5.01, p=0.025 for NR2B 5073G alleles and chi(2)=11.75, p<0.001 for SK3 L alleles including >19 repeats).
|
16157352 |
2007 |
|
Anorexia Nervosa
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We then stratified the MAOA-uVNTR TDT data according to the (a) NETpPR genotype of the AN-R females, and (b) NETpPR allele transmitted from NETpPR-S4/L4 heterozygous mothers.
|
14508509 |
2003 |
|
Asthma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We apply an empirical variance estimation method, which is implemented in the program package FBAT, on Caucasian families with asthma in the presence and absence of linkage and compare the results with those obtained using the TDT (TDTEX-PAIRS) on the same data sets.
|
11793685 |
2001 |
|
Attention deficit hyperactivity disorder
|
0.080 |
Biomarker
|
disease |
BEFREE |
This association is particularly pronounced among male ADHD probands without any comorbidity (50 trios, HHRR: chi(2) = 5.128, P = 0.024, df = 1; TDT: chi(2) = 4.558, P = 0.033, df = 1), especially the ADHD-I subtype (32 trios, HHRR: chi(2) = 5.792, P = 0.016, df = 1; TDT: chi(2) = 5.333, P = 0.021, df = 1).
|
12627475 |
2003 |
|
Attention deficit hyperactivity disorder
|
0.080 |
Biomarker
|
disease |
BEFREE |
The negative TDT finding between DAT1 and DRD4 VNTR polymorphisms and ADHD should be interpreted with caution; partly due to lack of power caused by low heterozygosity in the study population.
|
16165273 |
2005 |
|
Attention deficit hyperactivity disorder
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
When haplotype TDT analysis of HTR4 was performed, we further found that the C/G haplotype of the 83097 C>T and 83198 A>G polymorphisms (chi(2)=8.783, P=0.003) and the C/G/C haplotype of these and the -36 C>T polymorphism (chi(2)=5.762, P=0.016) were under-transmitted to probands with ADHD.
|
16563621 |
2006 |
|
Attention deficit hyperactivity disorder
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
TDT analysis of the data yielded two polymorphisms that were significantly associated with ADHD (rs2770112-Transmitted: 71 Not Transmitted; 48; rs12861247-Transmitted: 43 Not Transmitted: 21), located towards the 5' end of the gene (P < 0.05).
|
18937300 |
2008 |
|
Attention deficit hyperactivity disorder
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
However TDT analysis showed no preferential transmission of allele 7 to ADHD probands.
|
11032386 |
2000 |
|
Attention deficit hyperactivity disorder
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Using case control analysis and then the TDT, no association was found between these two MAOA polymorphisms and ADHD.
|
12497620 |
2003 |
|
Attention deficit hyperactivity disorder
|
0.080 |
Biomarker
|
disease |
BEFREE |
A categorical TDT yielded no significant findings, but the number of transmissions was small, especially for ADHD-inattentive type.
|
9774775 |
1998 |
|
Attention deficit hyperactivity disorder
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest a significant association of ADHD with SNP rs498793 (case-control p = .004, odds ratio [OR] 1.6, 95% confidence interval [CI] 1.15-2.23; transmission disequilibrium test [TDT] p = .014, OR 1.69) in the fatty acid desaturase 2 (FADS2) gene.
|
16893529 |
2006 |
|
Autistic Disorder
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
In TDT analysis, rs69510130 (p=0.027) showed nominal associations with autism; modest haplotype association was also observed.
|
21118708 |
2011 |
|
Autistic Disorder
|
0.070 |
Biomarker
|
disease |
BEFREE |
In the TDT of autism trios, the SNP haplotype combinations showed significant associations in the autism group.
|
17349978 |
2007 |
|
Autistic Disorder
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
However, when a meta-analysis of all the available TDT data, inclusive of the present study is carried out, we observed a significant preferential transmission of S-allele from parents to the affected offspring (chi2 = 7.51, P = 0.006) indicating an association of 5-HTTLPR with autism.
|
16674932 |
2006 |
|
Autistic Disorder
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
As predicted, Caucasian-American and not Italian families display a significant association between autism and PON1 variants less active in vitro on the OP diazinon (R192), according to case-control contrasts (Q192R: chi2=6.33, 1 df, P<0.025), transmission/disequilibrium tests (Q192R: TDT chi2=5.26, 1 df, P<0.025), family-based association tests (Q192R and L55M: FBAT Z=2.291 and 2.435 respectively, P<0.025), and haplotype-based association tests (L55/R192: HBAT Z=2.430, P<0.025).
|
16027737 |
2005 |
|
Autistic Disorder
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
In single SNP TDT analysis, C270T showed preferential transmission of the T allele compared to the C allele (TDT p < 0.001) in autism.
|
20201430 |
2009 |
|
Autistic Disorder
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
TPH2 alleles and haplotypes are not significantly associated in our sample with autism (rs4570625: TDT P = 0.27, and FBAT P = 0.35; rs4565946: TDT P = 0.45, and FBAT P = 0.55; haplotype P = 0.84), with any endophenotype, or with the presence/absence of prominent repetitive and stereotyped behaviors (motor stereotypies: P = 0.81 and 0.84, verbal stereotypies: P = 0.38 and 0.73 for rs4570625 and rs4565946, respectively).
|
17346350 |
2007 |
|
Autistic Disorder
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Therefore in the present study, we have performed genetic analysis of three markers of GluR6 (SNP1: rs2227281, SNP2: rs2227283, SNP3: rs2235076) for possible association with autism through population, and family-based (TDT and HHRR) approaches.
|
17712621 |
2007 |
|
Bipolar Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Additional allelic association and TDT studies of 4p markers in bipolar disorder and in schizophrenia might be able to narrow the focus of the 4p investigations.
|
9686426 |
1998 |