|
Absence of sensation
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Ninety-nine patients who met the inclusion criteria and presented with carious lesions were randomly allocated to receive either ART or conventional restorations (anaesthesia, rotary instruments and resin-modified glass ionomer).
|
30862556 |
2019 |
|
Acromegaly
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The plasma AgRP levels were higher in those with active acromegaly than in the matched healthy subjects [median, 100 pg/mL; interquartile range (IQR), 78 to 139 pg/mL vs median, 63 pg/mL; IQR, 58 to 67 pg/mL; P < 0.0001].
|
31361303 |
2019 |
|
Acute HIV infection
|
0.020 |
Biomarker
|
disease |
BEFREE |
In contrast, the fully differentiated HIV-specific CD8<sup>+</sup> T cells at peak viremia in AHI stage 3 were more prone to apoptosis but were associated with a steeper viral load decrease after ART initiation.
|
28202771 |
2017 |
|
Acute HIV infection
|
0.020 |
Biomarker
|
disease |
BEFREE |
We therefore measured systemic levels of 84 soluble biomarkers belonging to a broad array of immune pathways in acute HIV infection in both antiretroviral therapy-naive (ART-naive) individuals as well as individuals who began ART upon early detection of HIV infection.
|
29769442 |
2018 |
|
Acute infectious disease
|
0.030 |
Biomarker
|
group |
BEFREE |
In adults starting ART during acute infection, 2% of proviruses that persist on ART are genetically intact by sequence analysis.
|
31776265 |
2020 |
|
Acute infectious disease
|
0.030 |
Biomarker
|
group |
BEFREE |
In a macaque simian-human immunodeficiency virus (SHIV) model, some macaques who were able to control SHIV replication after ART interruption showed expansion of Env-specific CD8 T cell responses during acute infection, compared to macaques who progressed to viral rebound.
|
29773224 |
2018 |
|
Acute infectious disease
|
0.030 |
Biomarker
|
group |
BEFREE |
Our study highlights the role of HIV replication and CTL control in reservoir accumulation in sanctuary sites and why ART appears to be more effective in acute infection.
|
27630237 |
2016 |
|
Addictive Behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Maximally-assisted therapy (MAT) is an interdisciplinary care intervention that includes ART dispensation to support individuals with a history of addiction and homelessness.
|
30269233 |
2019 |
|
Adrenal Cushing's syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Plasma AgRP in the patients with Cushing's syndrome following bilateral adrenalectomy and hydrocortisone replacement were similar to the levels seen in controls.
|
16320160 |
2005 |
|
Adrenal Gland Pheochromocytoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These data (1) confirm that ART acts as a differentiation factor for autonomic (chiefly sympathoadrenal but also parasympathetic) neurons, (2) suggest a role for ART overexpression in the genesis of pheochromocytomas and paragangliomas, and (3) indicate that ART is not a suitable therapy for peripheral neuropathy.
|
15204970 |
2005 |
|
Adult Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Competition assays were used to measure the relative binding affinities of engineered AgRP peptides for integrin receptors expressed on the surface of U87MG glioblastoma cells.
|
20124048 |
2010 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
ADF also enhanced IL 2-R expression of a rat T cell line transformed by HTLV-1(TARS-1), as demonstrated with anti-rat IL 2 receptor monoclonal antibodies (ART-18).
|
2999237 |
1985 |
|
Advanced Head and Neck Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The CONDOR study showed that docetaxel/cisplatin/5-fluorouracil (TPF) followed by conventional radiotherapy with cisplatin 100 mg/m<sup>2</sup> on days 1, 22, and 43 (cis100 + RT; n = 27)) versus accelerated radiotherapy with cisplatin weekly 40 mg/m<sup>2</sup> (cis40 + ART; n = 29) in locally advanced head and neck cancer (LAHNC) patients was not feasible.
|
29230548 |
2018 |
|
AIDS defining illness
|
0.010 |
Biomarker
|
disease |
BEFREE |
Women who modified/discontinued a drug class or died due to an AIDS defining illness were classified as ART-failures.
|
24586673 |
2014 |
|
AIDS-Associated Nephropathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to assess, the efficacy and safety of add-on corticosteroids to antiretroviral therapy [ART] in patients with biopsy proven HIV associated nephropathy.
|
30728003 |
2019 |
|
Alcohol abuse
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study evaluates whether a group intervention that included cognitive remediation improved ART adherence, service utilization, and viral load among HIV-positive adults with a history of alcohol abuse.
|
31637608 |
2019 |
|
Alcohol or Other Drugs use
|
0.020 |
Biomarker
|
disease |
BEFREE |
The Longitudinal Effects of Non-injection Substance Use on Sustained HIV Viral Load Undetectability Among MSM and Heterosexual Men in Brazil and Thailand: The Role of ART Adherence and Depressive Symptoms (HPTN 063).
|
30725397 |
2019 |
|
Alcohol or Other Drugs use
|
0.020 |
Biomarker
|
disease |
BEFREE |
Having 2 years and above duration on ART [AOR = 7, 95% CI (2.2, 22.6)], history of adverse effect [AOR = 6.9, 95% CI (1.4, 32.9)], substance use [AOR = 5.3, 95% CI (1.4, 20.0)], living with parents [AOR = 3.4, 95% CI (1.2, 10.3)], having depression symptom [AOR = 3.3, 95% CI (1.4, 7.5)], <350 cells/mm<sup>3</sup> cluster of differentiation 4 count [AOR = 3.2, 95% CI (1.8, 5.8)] and low dietary diversity [AOR = 2, 95% CI (1.1, 3.7)] were found significant determinants of non-adherence to antiretroviral drug.
|
28331527 |
2017 |
|
Anal squamous cell carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Scans from 26 patients participating in the ART trial (full title: Anal squamous cell carcinoma: Investigation of functional imaging during chemoRadioTherapy), a single center observational study with FDG PETCT prior to radiotherapy and at fraction 8-10 of concurrent chemoradiation were analysed.
|
31506182 |
2020 |
|
Anemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Low nutritional status at the start of ART evidenced by underweight and anemia were found to be predictors of survival among HIV positive children.
|
31801487 |
2019 |
|
Anorexia Nervosa
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
These data indicate that variations of AGRP are associated with susceptibility for AN.
|
11326303 |
2001 |
|
Anorexia Nervosa
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
One variant of the AgRP gene was associated with anorexia nervosa, thus putting forward melanocortin receptor blockade as putative pharmacotherapy.
|
11704425 |
2001 |
|
Anorexia Nervosa
|
0.070 |
Biomarker
|
disease |
BEFREE |
Family trios analysis of common polymorphisms in the obestatin/ghrelin, BDNF and AGRP genes in patients with Anorexia nervosa: association with subtype, body-mass index, severity and age of onset.
|
17197106 |
2007 |
|
Anorexia Nervosa
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
AGRP rs13338499 polymorphism was associated with lowest illness-related BMI in those with AN (p = 0.0013), and NTRK2 rs1042571 was associated with highest BMI in those with BN (p = 0.0018).
|
24831852 |
2014 |
|
Anorexia Nervosa
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Functional analysis of the Ala67Thr polymorphism in agouti related protein associated with anorexia nervosa and leanness.
|
15927146 |
2005 |