|
Obesity
|
0.700 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Obesity
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
|
Thinness
|
0.100 |
CausalMutation
|
phenotype |
CLINVAR |
|
|
|
|
OBESITY, LATE-ONSET
|
0.100 |
GeneticVariation
|
phenotype |
CLINVAR |
|
|
|
|
Decreased resting energy expenditure
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Increased waist to hip ratio
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Adult T-Cell Lymphoma/Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
ADF also enhanced IL 2-R expression of a rat T cell line transformed by HTLV-1(TARS-1), as demonstrated with anti-rat IL 2 receptor monoclonal antibodies (ART-18).
|
2999237 |
1985 |
|
Leukemia, Myelocytic, Acute
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A novel variant of the chimerical MLL-AF10 mRNA transcript was detected in a pediatric patient with acute myeloid leukemia (AML) by a new asymmetric reverse-transcription polymerase chain reaction (ART-PCR) method.
|
9305618 |
1997 |
|
Obesity
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Ubiquitous expression of human AGRP complementary DNA in transgenic mice caused obesity without altering pigmentation.
|
9311920 |
1997 |
|
Hypertensive disease
|
0.060 |
GeneticVariation
|
group |
BEFREE |
With this in mind, and recent advances in state of the art gene delivery system coupled with the anticipated completion of the human genome project, it is timely to think about the possibility of treating and/or curing hypertension using genetic means.
|
10779083 |
2000 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This variable expressivity of MC4-R-associated obesity is not due to variations in genes for alpha-MSH or AGRP.
|
10903341 |
2000 |
|
Hyperphagia
|
0.200 |
Biomarker
|
phenotype |
RGD |
Rats rendered diabetic by streptozotocin displayed marked hyperglycemia (blood glucose 456.0+/-8.4 mg/dl versus 71.8+/-1.9 mg/dl) and hyperphagia (36.9+/-1.0 g/day versus 22.0+/-0.4 g/day), that was associated with a 286.6+/-4.4% increase in hypothalamic AGRP mRNA and a 178.9+/-13.5% increase in hypothalamic NPY mRNA.
|
11179781 |
2001 |
|
Anorexia Nervosa
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
These data indicate that variations of AGRP are associated with susceptibility for AN.
|
11326303 |
2001 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Mutations in AGRP and alpha MSH genes were not among the causes of obesity in our population.
|
11487744 |
2001 |
|
Obesity, Morbid
|
0.030 |
Biomarker
|
disease |
BEFREE |
To search for mutations in melanocortin pathway elements, that is, the melanocortin-4 receptor (MC4R ), agouti-related protein (AGRP ), and (alpha-melanocyte-stimulating hormone (alpha MSH ) genes in children with severe obesity.
|
11487744 |
2001 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
A role for the Agouti-Related Protein promoter in obesity and type 2 diabetes.
|
11554767 |
2001 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.210 |
Biomarker
|
disease |
BEFREE |
A role for the Agouti-Related Protein promoter in obesity and type 2 diabetes.
|
11554767 |
2001 |
|
Anorexia Nervosa
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
One variant of the AgRP gene was associated with anorexia nervosa, thus putting forward melanocortin receptor blockade as putative pharmacotherapy.
|
11704425 |
2001 |
|
Prader-Willi Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Hypothalamic NPY and agouti-related protein are increased in human illness but not in Prader-Willi syndrome and other obese subjects.
|
11836343 |
2002 |
|
Kaposi Sarcoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
RTA (replication and transcription activator; also referred to as ORF50, Lyta, and ART), an immediate-early gene product of Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8, disrupts latency and drives lytic replication.
|
11967316 |
2002 |
|
Obesity
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The c.199G-->A polymorphism in hAGRP could, therefore, play a role in the development of human obesity in an age-dependent fashion.
|
12213871 |
2002 |
|
Malaria, Falciparum
|
0.010 |
Biomarker
|
disease |
BEFREE |
We recently found artesunate plus sulfadoxine-pyrimethamine (ART-SP) to be highly effective (96%) in the treatment of falciparum malaria in Papua Province.
|
12435700 |
2002 |
|
Spinal Muscular Atrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Private ART laboratory.Two couples undergoing IVF for infertility therapy, both of whom had previously delivered offspring afflicted with spinal muscular atrophy (type 1) after IVF therapy, and who underwent subsequent cycles of IVF coupled with PGD to screen for this disorder.
|
12909515 |
2003 |
|
Obesity
|
0.700 |
Biomarker
|
disease |
BEFREE |
The currently available data suggest that elevated AGRP mRNA along with reduced proopiomelanocortin (POMC) mRNA is associated with many types of obesity and agents antagonizing the effect of AGRP may be a potential therapeutic target in treating obesity and obesity-associated disorders in which endogenous hypothalamic AGRP is elevated.
|
14572167 |
2003 |
|
HIV viraemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
We previously demonstrated that short-cycle structured intermittent therapy (SIT; 7 days without therapy followed by 7 days with antiretroviral therapy [ART]) with a ritonavir-boosted, indinavir-based, twice-daily regimen maintained suppression of plasma HIV viremia while reducing serum levels of lipids.
|
15143462 |
2004 |