AGRP, agouti related neuropeptide, 181

N. diseases: 233; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030421
Disease: Paraganglioma
Paraganglioma 		0.010 Biomarker disease BEFREE These data (1) confirm that ART acts as a differentiation factor for autonomic (chiefly sympathoadrenal but also parasympathetic) neurons, (2) suggest a role for ART overexpression in the genesis of pheochromocytomas and paragangliomas, and (3) indicate that ART is not a suitable therapy for peripheral neuropathy. 15204970 2005
CUI: C0031117
Disease: Peripheral Neuropathy
Peripheral Neuropathy 		0.010 Biomarker group BEFREE These data (1) confirm that ART acts as a differentiation factor for autonomic (chiefly sympathoadrenal but also parasympathetic) neurons, (2) suggest a role for ART overexpression in the genesis of pheochromocytomas and paragangliomas, and (3) indicate that ART is not a suitable therapy for peripheral neuropathy. 15204970 2005
CUI: C0031511
Disease: Pheochromocytoma
Pheochromocytoma 		0.010 AlteredExpression disease BEFREE These data (1) confirm that ART acts as a differentiation factor for autonomic (chiefly sympathoadrenal but also parasympathetic) neurons, (2) suggest a role for ART overexpression in the genesis of pheochromocytomas and paragangliomas, and (3) indicate that ART is not a suitable therapy for peripheral neuropathy. 15204970 2005
CUI: C4551683
Disease: Adrenal Gland Pheochromocytoma
Adrenal Gland Pheochromocytoma 		0.010 AlteredExpression disease BEFREE These data (1) confirm that ART acts as a differentiation factor for autonomic (chiefly sympathoadrenal but also parasympathetic) neurons, (2) suggest a role for ART overexpression in the genesis of pheochromocytomas and paragangliomas, and (3) indicate that ART is not a suitable therapy for peripheral neuropathy. 15204970 2005
CUI: C4721453
Disease: Peripheral Nervous System Diseases
Peripheral Nervous System Diseases 		0.010 Biomarker group BEFREE These data (1) confirm that ART acts as a differentiation factor for autonomic (chiefly sympathoadrenal but also parasympathetic) neurons, (2) suggest a role for ART overexpression in the genesis of pheochromocytomas and paragangliomas, and (3) indicate that ART is not a suitable therapy for peripheral neuropathy. 15204970 2005
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa 		0.070 GeneticVariation disease BEFREE Functional analysis of the Ala67Thr polymorphism in agouti related protein associated with anorexia nervosa and leanness. 15927146 2005
CUI: C0028754
Disease: Obesity
Obesity 		0.700 GeneticVariation disease BEFREE An association study of the AGRP -38C/T SNP and indices of obesity and diabetes status. 16130030 2006
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.050 GeneticVariation group BEFREE An association study of the AGRP -38C/T SNP and indices of obesity and diabetes status. 16130030 2006
CUI: C0011847
Disease: Diabetes
Diabetes 		0.030 GeneticVariation disease BEFREE An association study of the AGRP -38C/T SNP and indices of obesity and diabetes status. 16130030 2006
CUI: C0012546
Disease: Diphtheria
Diphtheria 		0.010 Biomarker disease BEFREE To determine whether NPY/AgRP neurons are essential in mice, we targeted the human diphtheria toxin receptor to the Agrp locus, which allows temporally controlled ablation of NPY/AgRP neurons to occur after an injection of diphtheria toxin. 16254186 2005
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa 		0.070 GeneticVariation disease LHGDN Mutation analysis of the agouti related protein promoter region and the melanocortin-3 receptor in anorexia nervosa patients. 16314751 2005
CUI: C0010481
Disease: Cushing Syndrome
Cushing Syndrome 		0.010 Biomarker disease BEFREE Plasma AgRP in the patients with Cushing's syndrome following bilateral adrenalectomy and hydrocortisone replacement were similar to the levels seen in controls. 16320160 2005
CUI: C0342443
Disease: Adrenal Cushing's syndrome
Adrenal Cushing's syndrome 		0.010 Biomarker disease BEFREE Plasma AgRP in the patients with Cushing's syndrome following bilateral adrenalectomy and hydrocortisone replacement were similar to the levels seen in controls. 16320160 2005
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.080 Biomarker group BEFREE The aim of this study was to ascertain whether a genetic alteration of ARTS gene is involved in the development of human cancers possibly by inactivating the apoptotic function of ART. 16376484 2006
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa 		0.070 Biomarker disease LHGDN Plasma agouti-related protein levels in women with anorexia nervosa. 16904835 2006
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa 		0.070 Biomarker disease BEFREE Family trios analysis of common polymorphisms in the obestatin/ghrelin, BDNF and AGRP genes in patients with Anorexia nervosa: association with subtype, body-mass index, severity and age of onset. 17197106 2007
CUI: C0242510
Disease: Drug usage
Drug usage 		0.070 Biomarker phenotype BEFREE Multivariable analysis including age, race, sex, HIV-1 RNA, prior antiretroviral therapy, probable route of infection, prior ADE, absolute CD4, and %CD4 was performed; prior ART (P<.0001), injection-drug use (P=.04), lower absolute CD4 (P=.002), and lower %CD4 (P=.002) predicted disease progression. 17205482 2007
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.100 Biomarker disease BEFREE The VERSANT HCV RNA 3.0 (bDNA), COBAS AmpliPrep/COBAS TaqMan HCV, and Abbott ART HCV RealTime assays were compared for hepatitis C virus RNA quantification in 158 clinical specimens (genotypes 1 to 5). 17581929 2007
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker disease RGD By contrast, although there was the expected increase in both NPY and AGRP expression in obese 14-week-old ZF rats, the expression of NPY and AGRP was decreased in 6-week-old obese ZDF rats with hyperinsulinaemia and in 14-week-old rats with the additional hyperglycaemia. 18001323 2007
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.210 Biomarker disease RGD Reduced expression of the KATP channel subunit, Kir6.2, is associated with decreased expression of neuropeptide Y and agouti-related protein in the hypothalami of Zucker diabetic fatty rats. 18001323 2007
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker disease BEFREE While forced activation of hypothalamic IKKbeta/NF-kappaB interrupts central insulin/leptin signaling and actions, site- or cell-specific suppression of IKKbeta either broadly across the brain or locally within the mediobasal hypothalamus, or specifically in hypothalamic AGRP neurons significantly protects against obesity and glucose intolerance. 18854155 2008
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.030 Biomarker phenotype BEFREE While forced activation of hypothalamic IKKbeta/NF-kappaB interrupts central insulin/leptin signaling and actions, site- or cell-specific suppression of IKKbeta either broadly across the brain or locally within the mediobasal hypothalamus, or specifically in hypothalamic AGRP neurons significantly protects against obesity and glucose intolerance. 18854155 2008
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.100 Biomarker disease BEFREE Twelve of 13 (92%) were receiving ART, with a mean CD4+ count of 428 cells microL(-1) (range 175-928 cells microL(-1)) at initiation of HCV therapy. 19187189 2009
CUI: C0021051
Disease: Immunologic Deficiency Syndromes
Immunologic Deficiency Syndromes 		0.080 Biomarker group BEFREE We evaluated NK cell subsets and functions in previously immunodeficient HIV patients responding to ART. 19403337 2009
CUI: C0028754
Disease: Obesity
Obesity 		0.700 GeneticVariation disease BEFREE The aim of the present study was to assess the genetic variability of AGRP gene and investigate whether the previously reported SNP rs5030980 and the rs11575892, a SNP that so far has not been studied with respect to obesity is associated with increased body mass index (BMI). 19602223 2009