|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
P2X7R blockade with oxidized ATP reduces the CD8<sup>+</sup> T cell-mediated autoimmune response in vitro and delays diabetes onset in NOD mice.
|
30065030 |
2018 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Prevention of diabetes in the NOD mouse by a Th1 clone specific for a hsp60 peptide.
|
10677244 |
2000 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We conclude that IA-2beta is involved in insulin secretion, but despite its importance as a major autoantigen in human type 1 diabetes, it is not required for the development of diabetes in NOD mice.
|
15220191 |
2004 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fenofibrate, a regulator of sphingolipid metabolism, is known to prevent diabetes in NOD mice.
|
31410530 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found that the CD19+IgM+ cell is the primary subpopulation of B cells that delayed transfer of diabetes mediated by diabetogenic T cells from NOD mice (P = 0.002).
|
30518692 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the resulting 3A9 TCR:iHEL NOD.H2(k)-Chr12 mice, we observed a significant decrease in diabetes incidence as well as a decrease in both the quantity and affinity of HEL-specific IgG autoantibodies relative to 3A9 TCR:iHEL NOD.H2(k) mice.
|
25623266 |
2015 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Available experiments in the NOD mouse and epidemiological evidence in the human point to proinsulin as a key autoantigen in diabetes.
|
16306346 |
2005 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Despite the well known role of nucleotide oligomerization domain (NOD) receptor proteins in innate immunity, their association with diabetes is less explored.
|
24018334 |
2013 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Islets were isolated from NOD mice and mice treated with multiple low doses of streptozotocin, as a mouse model of diabetes.
|
28280903 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, splenocytes from NOD-Alox15(null) mice are unable to transfer diabetes in an adoptive transfer model.
|
23437231 |
2013 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
This was demonstrated by greater ability to cause recurrent diabetes in NOD-RIP-CD86 diabetic mice transplanted with 6-wk-old NOD islets and adoptively transferred diabetes from diabetic NOD-RIP-CD86 mice to NOD.scid mice.
|
17947667 |
2007 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans.
|
11016460 |
2000 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Because exogenous IL-4 and IL-10 exert antidiabetogenic effect in NOD mice and early blockade of endogenous tumor necrosis factor-alpha prevents NOD mouse diabetes, these phenomena may be causally related to the antidiabetogenic effect of HGG-pulsed DC treatment.
|
10746656 |
2000 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We conclude that treatment of NOD mice with an antibody against CSF-1 receptor reduced diabetes incidence and led to the development of a regulatory pathway that controlled autoimmune progression.
|
29133420 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
L-serine supplementation lowers diabetes incidence and improves blood glucose homeostasis in NOD mice.
|
29543915 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
By using the recombinant PLAD.Fc protein to block TNFR1 assembly, we demonstrated that PLAD.Fc treatment significantly reduced the TNFR1-driving proinflammatory cytokines and protected NOD mice from diabetes.
|
21689905 |
2011 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Oral vaccination with H6P-loaded targeting NPs induced antigen-specific T cell tolerance and prevented diabetes in 100% of NOD mice.
|
29546475 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
A single administration of rAd-GLP-1 via the tail vein into streptozotocin (STZ)-induced diabetic non-obese diabetic/severe combined immunodeficient (NOD/SCID) mice resulted in remission of diabetes within 10 days; normoglycemia remained until the experiment was terminated.
|
17164779 |
2007 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we used direct non-invasive confocal imaging of islets transplanted in the anterior chamber of the eye (ACE) to investigate the anti-islet autoimmunity in NOD mice before, during and after diabetes onset.
|
31087105 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
STZ-treated mice, NOD mice, and adoptive-transfer mice demonstrate altered islet blood-flow dynamics prior to diabetes onset, consistent with islet microvasculature reorganization.
|
29717116 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Stat5b-CA.DC-educated CD4<sup>+</sup>CD25<sup>-</sup> T cells delayed diabetes onset whereas Stat5b-CA.DC-educated Tregs blocked ongoing diabetes in 8-10 weeks old NOD recipient mice.
|
27634616 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Blockade of IFNAR1 in prediabetic NOD mice accelerated diabetes and increased Th1 responses.
|
29415894 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we show that proinsulin B24-C36 peptide binds to I-A(g7), the MHC class II molecule of the NOD mouse, and, after intranasal administration, induces regulatory CD4(+) T cells that, in the absence of CD8(+) T cells, block the adoptive transfer of diabetes.
|
12727928 |
2003 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thioredoxin-interacting protein (TXNIP), a regulator of cellular oxidative stress, has been associated with activation of NOD-like receptor 3 (NLRP3) inflammasome, inflammation and lipid metabolism, suggesting it has a role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) in diabetes.
|
23647015 |
2013 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
To test the role of gut microbiota on diabetes development in this model system, we treated the <i>A22Cα<sup>-/-</sup>PI2<sup>-/-</sup></i> NOD mice with enrofloxacin, a broad-spectrum antibiotic.
|
30796028 |
2019 |