|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
In crosses of NOD mice with a series of normal strains, inheritance overt diabetes is correlated with inheritance of the NOD's unique I-A beta gene, though the bulk of islet destruction and insulitis can occur independent of MHC inheritance.
|
2642771 |
1989 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It can be induced by as disparate means as tuberculin antigen administration, by interleukin-4 treatments, by transfer of T-cell lines generated in autologous mixed lymphocyte responses, and by immunization to insulin B-chain, whereas oral islet cell antigens, such as insulin, can delay diabetes onset in the NOD mouse.(ABSTRACT TRUNCATED AT 250 WORDS)
|
8100786 |
1993 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nicotinamide can protect the NOD mouse from diabetes if given early enough and in sufficient dose.The effect partly wanes with time.There is reduced islet inflammation.
|
8109840 |
1993 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
NOR mice are insulitis resistant and diabetes free despite genetic identity with NOD at numerous chromosomal regions containing previously described insulin-dependent diabetes (Idd) genes, including the strongly diabetogenic H2g7 major histocompatibility complex (MHC) haplotype.
|
7931087 |
1994 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
All splice variants encode the conserved T-cell epitope (in exon 2) recognized by autoreactive T cells in diabetic children and diabetes-prone NOD mice.
|
8975715 |
1996 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We show that diabetes-prone NOD mice had Tep69-specific, autoreactive T cell repertoires and thus provide a relevant model for the study of ICA69's role in diabetic autoimmunity.
|
9128175 |
1997 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We reported that oral administration of 0.8 mg of recombinant human insulin to 6-week-old NOD mice every other day for a month generated regulatory T-cells that were able to reduce the severity of insulitis and the percentage of clinical diabetes in naive irradiated recipients when co-injected with diabetogenic T-cells.
|
9421372 |
1998 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
To optimize the induction of tolerance, we have shown that feeding insulin conjugated to cholera toxin B-subunit (CTB), a potent mucosal adjuvant, reduced by 5,000 the amounts of antigen necessary for delaying diabetes onset in NOD mice.
|
10535448 |
1999 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Targeted immunomodulation by treatment of recipients with either anti-helper T-cell antibodies, or fusion proteins which block costimulatory interactions between antigen presenting cells and host T-cells have demonstrated synergy in significant prolongation of encapsulated islet xenograft survival in NOD mice with spontaneous diabetes.
|
10415571 |
1999 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We evaluated two bone marrow-derived dendritic cell (DC) populations from NOD mice, the murine model for type 1 human diabetes.
|
10580417 |
1999 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We evaluated the effects of recombinant human (rh) interleukin (IL)-11 on the development of spontaneous and cyclophosphamide-induced diabetes in female NOD mice.
|
10580421 |
1999 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Clone C9 can adoptively transfer diabetes or, when attenuated, C9 can be used to vaccinate NOD mice against diabetes.
|
10360969 |
1999 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Vitamin D has been shown to modulate the immune system thereby preventing the development of diabetes in NOD mice.
|
10593571 |
1999 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Prevention of diabetes in the NOD mouse by a Th1 clone specific for a hsp60 peptide.
|
10677244 |
2000 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans.
|
11016460 |
2000 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Because exogenous IL-4 and IL-10 exert antidiabetogenic effect in NOD mice and early blockade of endogenous tumor necrosis factor-alpha prevents NOD mouse diabetes, these phenomena may be causally related to the antidiabetogenic effect of HGG-pulsed DC treatment.
|
10746656 |
2000 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Because type 1 diabetes is regarded to be immune-mediated and vitamin D prevents the development of diabetes in the NOD mouse, we investigated the role of the vitamin D receptor (VDR) gene as a candidate for type 1 diabetes susceptibility.
|
10868975 |
2000 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, NOD/LtSz-Rag1null recipients of adoptively transferred spleen cells from diabetic NOD/Lt+/+ mice rapidly developed diabetes.
|
10679087 |
2000 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
This review will focus on the genetic components predisposing NOD mice to SLE induced by BCG treatment and compare them to previously determined diabetes susceptibility genes in this strain and SLE susceptibility genes in the BXSB, MRL and the New Zealand mouse strains.
|
11681493 |
2001 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present study we tried to identify immune reactivity patterns in the pancreas associated with diabetes resistance in NOD-related mouse strains.
|
11409710 |
2001 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
While both isoforms of glutamic acid decarboxylase (GAD) function as important autoantigens in autoimmune diabetes mellitus-GAD65 in humans and GAD67 in the NOD mouse-GAD67 is not synthesized in human pancreatic islets and is thought not to be an autoantigen in human diabetes.
|
12515288 |
2002 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we show that proinsulin B24-C36 peptide binds to I-A(g7), the MHC class II molecule of the NOD mouse, and, after intranasal administration, induces regulatory CD4(+) T cells that, in the absence of CD8(+) T cells, block the adoptive transfer of diabetes.
|
12727928 |
2003 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
T lymphocytes isolated from the islets of the NOD mouse that recognize insulin peptide B:9-23 can transfer diabetes.
|
14679045 |
2003 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We conclude that IA-2beta is involved in insulin secretion, but despite its importance as a major autoantigen in human type 1 diabetes, it is not required for the development of diabetes in NOD mice.
|
15220191 |
2004 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interleukin-18 (IL-18) is a potent proinflammatory cytokine which is strongly associated with the development of diabetes in NOD mice.
|
14709415 |
2004 |