|
Abnormality of the urinary system
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Abortion, Tubal
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Gene expression in cultured endometrium from women with different outcomes following IVF.
|
18539642 |
2008 |
|
Acromegaly
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
It can be said that the angiotensinogen MT and AT1R CC1166 genotype carriers may have more risk than other genotypes in the development of hypertension in acromegaly.
|
20361261 |
2011 |
|
Acute Cerebrovascular Accidents
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The results of this study show no relationship between the A1166C polymorphism in the AT1 gene and acute stroke in the Turkish population.
|
23480670 |
2013 |
|
Acute Chest Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
AT1R (rs 5182) CT genotype is mildly associated with STEMI (OR = 1.1), but also prone to have PCI after ACS attack (OR = 1.6) while TT genotype has a risk to get less improvement (OR = 1.8).
|
31195108 |
2020 |
|
Acute Coronary Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
Autoantibodies targeting AT1 receptor from patients with acute coronary syndrome upregulate proinflammatory cytokines expression in endothelial cells involving NF-κB pathway.
|
25762441 |
2014 |
|
Acute Coronary Syndrome
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
This study aims to investigate the impact of ACE (rs4343) and AT1R (rs 5182) genetic polymorphisms on the outcome of acute coronary syndrome (ACS) in patients on captopril.
|
31195108 |
2020 |
|
Acute heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
TRV027, a 'biased' ligand of the angiotensin II type 1 receptor (AT1R), did not affect a composite clinical outcome at 30 days in a phase 2b acute heart failure (AHF) trial (BLAST-AHF).
|
28986703 |
2018 |
|
Acute myocardial infarction
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated the relationship between the angiotensin II type-1 receptor (AT1R) gene polymorphism and the blood flow characteristics of common carotid arteries (CCA) and BA by color Doppler ultrasound (CDUS) in patients with a first anterior acute myocardial infarction (AMI).
|
16911325 |
2006 |
|
Acute myocardial infarction
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present study aimed to evaluate whether angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1 receptor blockers (ARBs) had any different effects on long-term CV and all-cause mortality in patients with AMI who received either agent from admission and were discharged alive from the hospital.
|
30130974 |
2018 |
|
Acute myocardial infarction
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The findings indicated that diminazene significantly reduced the levels of inflammatory factors including tumor necrosis factor‑α and interleukin‑6, suppressed the protein expression of cytochrome c oxidase subunit 2 (COX‑2) and inducible nitric oxide synthase (iNOS), and activated angiotensin‑converting enzyme 2 (ACE2), angiotensin II receptor type 1 (AT1R) and MAS1 proto‑oncogene, G protein‑coupled receptor (MasR) protein expression in AMI model rats.
|
28791381 |
2017 |
|
Acute myocardial infarction
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association between A/C1166 gene polymorphism of the angiotensin II type 1 receptor and biventricular functions in patients with acute myocardial infarction.
|
16998258 |
2006 |
|
Acute myocardial infarction
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The AT1R 1166A/C polymorphism has association with AMI among north Indian patients, particularly if integrated with ACE I/D polymorphism and smoking.
|
22392878 |
2012 |
|
Acute myocardial infarction
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Double homozygous combinations for normal alleles (MM of AGT, II of ACE and AA of AGTR1) had a lower risk of AMI (odds ratio<0.38), indicating a protective effect in these individuals.
|
16061119 |
2005 |
|
Acute myocardial infarction
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The insertion/deletion (I/D) polymorphism in the ACE gene and the A1166C polymorphism in the AT1R gene have been associated with left ventricular remodelling and prognosis after acute myocardial infarction (AMI).
|
15785027 |
2005 |
|
Acute myocardial infarction
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The A1166C polymorphism of the angiotensin II type-1 receptor in acute myocardial infarction.
|
15543360 |
2004 |
|
Acute myocardial infarction
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In 82 coronary artery disease (CAD) patients and healthy controls (CTL), expressions of angiotensin I-converting enzyme (ACE), angiotensin AT1 receptor and DC-specific ICAM-3-grabbing nonintegrin (DC-SIGN) on DCs were measured by western-blot: CAD patients had an increased expression of ACE, AT1 receptor and DC-SIGN compared to controls especially in acute myocardial infarction (AMI).
|
19669395 |
2009 |
|
Acute myocardial infarction
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to assess the association of angiotensin II type 1 receptor (ATR1) gene polymorphisms with AMI as well as to evaluate the role of serum angiotensin-converting enzyme (ACE) activity and that of cardiac troponin I (cTnI) in Tunisian AMI patients.
|
21330421 |
2011 |
|
Acute respiratory distress
|
0.010 |
Biomarker
|
disease |
BEFREE |
The balance between Ang II/AT1R and Ang-(1-7)/Mas plays a pivotal role in the development of lipopolysaccharides (LPS)-induced acute respiratory distress syndrome.
|
30537127 |
2019 |
|
Acute respiratory failure
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The final model which included >5 risk alleles in the CYP1A1 (rs2606345, rs4646903, rs1048943), GCLC, AGT, and AGTR1 genes was associated with pleuritis, empyema, acute respiratory distress syndrome, all PC and acute respiratory failure (ARF).
|
24068433 |
2013 |
|
Adenocarcinoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
The RT-PCR showed that AT1 receptor expression in well-differentiated adenocarcinoma was higher than that in poorly differentiated adenocarcinoma.
|
16369744 |
2005 |
|
Adenocarcinoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
AT1R was expressed in 57 of 67 (85%) invasive ovarian adenocarcinomas and 12 of 18 (66%) borderline malignant tumors but in only 2 of 14 (14%) benign cystadenomas.
|
15814650 |
2005 |
|
Adenocarcinoma Of Esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
The angiotensin II type 1 receptor antagonist telmisartan inhibits cell proliferation and tumor growth of esophageal adenocarcinoma via the AMPKα/mTOR pathway in vitro and in vivo.
|
28052030 |
2017 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
The present study aimed to evaluate the potential usage of angiotensin II receptor type 1 (<i>AGTR1</i>) methylation in two major pathologic subtypes: Lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC).
|
29085512 |
2017 |
|
Adenoma
|
0.020 |
GeneticVariation
|
group |
BEFREE |
In patients with aldosterone-producing adenomas either responsive or unresponsive to the renin-angiotensin system, no differences were detected using SSCP analysis in the coding region of the AT1 receptor gene in peripheral blood or tumour tissue.
|
8582102 |
1996 |