Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
AT1 receptor blocker azilsartan medoxomil normalizes plasma miR-146a and miR-342-3p in a murine heart failure model.
|
27321284 |
2017 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
The target of the current study was to examine the possible cardioprotective effect of telmisartan (Tel), an angiotensin II type 1 receptor (AT1R) blocker, compared with that of captopril (Cap), an angiotensin converting enzyme (ACE) inhibitor, in ameliorating PRG-induced HF in rats by assessing morphometric, echocardiographic and histopathological parameters.
|
31629013 |
2019 |
Heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We genotyped 134 patients with HF and reduced systolic function for the AT1R A1166C genotype using polymerase chain reaction and restriction fragment length polymorphism.
|
18612202 |
2009 |
Heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this meta-analysis suggests that the A1166C polymorphism in AT1R may not be associated with susceptibility to HF.
|
26345849 |
2015 |
Heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Here we demonstrate that a polymorphism in the AT1R gene (A1166C), linked to increased receptor activity, is associated with elevated levels of oxidative stress markers in heart failure patients but not in healthy controls.
|
16651460 |
2006 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
In conclusion, the diminished angiotensin II vasoconstriction with age in heart failure patients is most likely due to a lower density of AT(1) receptors and may result from a longer period of exposure to heart failure in older patients.
|
15569271 |
2004 |
Heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The results were independent of the etiology of the heart failure and suggest that increased levels of atrial AT1R mRNA may occur in response to elevated atrial pressures in heart failure.
|
9281460 |
1997 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this paper, we review the recent advances in the field of β-arrestin signaling of the AT1R, emphasizing its role in cardiovascular regulation and heart failure.
|
31447777 |
2019 |
Heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The Chinese herbal formula SNT could improve left ventricular systolic function in heart failure after myocardial infarction in rats and decreased the level of Plasma Renin, Angiotensin II, and Aldosterone, as well as downregulating the protein and gene level of ACE and AT1R.
|
30050591 |
2018 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
We compared the effects of sudden stretch to SFR as well as to twitch and Ca2+ transient characteristics in rat myocardium with monocrotaline-induced heart failure with those in normal rat myocardium without and with inhibition of angiotensin II type-1 (AT1) receptors.
|
29593122 |
2018 |
Heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A prospective study of the impact of AGTR1 A1166C on the effects of candesartan in patients with heart failure.
|
29701105 |
2018 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Heart failure-related genes, such as brain natriuretic peptide, connective tissue growth factor and osteopontin; calcium signaling-related genes, such as ryanodine receptor 2, sarcoendoplasmic reticulum Ca(2+)-ATPase 2A2 and adenylate cyclase 7; renin-angiotensin system-related genes, such as angiotensinogen, angiotensin II receptor, type 1 and type 2; and mitochondria-related genes, such as peroxisome proliferator-activated receptor-gamma co-activator-1alpha, cytochrome c and transcription factor A mitochondrial, were significantly changed at the apical ventricle rather than at the basal ventricle.
|
19300450 |
2009 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
These data suggest that the serum levels of ghrelin are significantly positively correlated with Ang II in CHF patients and that ghrelin can inhibit Ang II-induced cardiomyocyte apoptosis by down-regulating AT1R, thereby playing a role in preventing HF.
|
24465706 |
2014 |
Heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
It may underlie the decrease in AT1 protein expression in human heart failure.
|
9302352 |
1997 |
Heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Thus, sensitization of the heart failure-promoting AT1 receptor by the RKIP-GRK2 interaction contributes to heart failure whereas dominant-negative GRK2-K220R is cardioprotective.
|
30687708 |
2018 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
These findings indicate that females are more susceptible to the adverse effects of AT1R stimulation than males favouring the development of HF and increased mortality.
|
29343862 |
2018 |
Heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The results of this proof-of concept study provide the first evidence that the AGTR1 A1166C polymorphism could influence the response to candesartan in patients with heart failure who are receiving ACE inhibitors.
|
18594050 |
2008 |
Heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In the heart failure treated with intracerebroventricular (ICV) infusion of angiotensin II type 1 receptor blocker (ARB), sympathetic activation and brain oxidative stress were significantly lower, and baroreflex sensitivity and volume tolerance were significantly higher than in heart failure treated with vehicle.
|
29495326 |
2018 |
Heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis showed significant associations between rs5186 in AGTR1 and increased rates by 25-34% for the primary endpoint (composite of death or nonfatal myocardial infarction, hospitalization for unstable angina, heart failure or peripheral vascular event), all-cause mortality, cardiovascular mortality and heart failure; all P < 0.001.
|
29982608 |
2019 |
Heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In human ventricles (n=13), message levels of atrial natriuretic peptide and AT(1) receptor were inversely correlated, which suggests a decrease in AT(1) receptor expression with progressive heart failure.
|
10715259 |
2000 |
Heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Intracellular Ang-II and nuclear AT1R protein levels were significantly increased in a heart failure model in which atrial fibrosis underlies atrial fibrillation.
|
28381466 |
2017 |
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A prospective study of the impact of AGTR1 A1166C on the effects of candesartan in patients with heart failure.
|
29701105 |
2018 |
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this meta-analysis suggests that the A1166C polymorphism in AT1R may not be associated with susceptibility to HF.
|
26345849 |
2015 |
Congestive heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The results were independent of the etiology of the heart failure and suggest that increased levels of atrial AT1R mRNA may occur in response to elevated atrial pressures in heart failure.
|
9281460 |
1997 |
Congestive heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We genotyped 134 patients with HF and reduced systolic function for the AT1R A1166C genotype using polymerase chain reaction and restriction fragment length polymorphism.
|
18612202 |
2009 |