Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Renal AT1R was found to be primarily responsible for Ang II-mediated hypertension.
|
30061705 |
2018 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Intranasal immunization with AT1R-PspA vaccine has the potential to simultaneously attenuate the development of hypertension and protect from lethal pneumococcal infection.
|
28832363 |
2018 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Polymorphisms in both the PPARG and AGTR1 genes were found to be significantly associated with hypertension.
|
29266977 |
2018 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
In the present work, we explored the changes in the expression of angiotensin II receptor, type 1 (AT<sub>1</sub> receptor) in limbic structures, as well as the effect of the AT1 receptor antagonist losartan in a model of comorbid hypertension and epilepsy.
|
29223539 |
2018 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Salt loading increased BP in both types of offspring, suggesting that elevated hypothalamic Agtr1a expression is epigenetically modulated by excessive glucocorticoid and leads to adult-onset salt-sensitive hypertension.
|
30385711 |
2018 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
During the treatment, angiotensin II type 1 receptor blockers and Ca antagonists were used to strictly control the axitinib-induced hypertension and proteinuria.
|
30158382 |
2018 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Thus, our data show that spinal ionotropic glutamatergic and AT1 receptors contribute to increased rSNA in the 2K1C model, leading to the maintenance of hypertension; however, the participation of spinal AT1 receptors seems to be especially important in the establishment of sympathoexcitation in this model.
|
29935157 |
2018 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Angiotensin II type I receptor agonistic autoantibody (AT1-AA) is closely related to pre-eclampsia, which is characterized by proteinuria and hypertension.
|
30380548 |
2018 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Progesterone attenuates hypertension and autoantibody levels to the angiotensin II type 1 receptor in response to elevated cadmium during pregnancy.
|
29405962 |
2018 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
There is an ongoing interest in the renin-angiotensin system (RAS) contribution either to pathological mechanisms leading to hypertension (mainly regarding the ACE/AngII/AT1R axis), or, to RAS protective and pro-regenerative actions, primarily ascribed to the mediation of the AT2R and the MAS1 receptor.
|
30498455 |
2018 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
<b>Conclusion:</b> Overexpression of β-arrestin1 in the RVLM reduces BP and sympathetic outflow in hypertension, which may be associated with NFκB-mediated AT1R downregulation.
|
29643817 |
2018 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Hap-I of AT1R gene is associated with hypertension in Caucasians.
|
30084918 |
2018 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The aim of this study was to investigate whether distribution of three putative regulatory SNPs rs13430086, rs5186, rs4606 in 3'UTR of genes ACVR2A, AGTR1 and RGS2, respectively, that have been associated with hypertension and regulation of trophoblast invasion differ between women with PE and control group.
|
29593124 |
2018 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Furthermore, we will examine the relationship between AT1-AA induced hypertension associated with increased oxidative stress, antiangiogenic factors (such as soluble fms-related tyrosine kinase-1 (sFlt-1), endothelin-1 (ET-1), inflammation, endothelial dysfunction, and reduced renal function.
|
30255752 |
2018 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Angiotensin II receptor type 1 (AT1) antagonists are the most recent drug class against hypertension.
|
29156380 |
2018 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
PVN microinjection of PKCγ siRNA had the same effect on LOS above responses to hypertension but no effect on PVN level of AT1R.
|
28338001 |
2017 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
The estimated effect implied that AGTR1 may have a protective effect for hypertension.
|
28381821 |
2017 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Blockers of angiotensin II type 1 receptor (AT<sub>1</sub>R) and the voltage gated calcium channel 1.2 (Ca<sub>V</sub>1.2) are commonly used for treatment of hypertension.
|
28514967 |
2017 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
We hypothesized that enhanced constrictive responsiveness of renal afferent arterioles (Af-Art) to angiotensin II (ANG II) mediated by ANG II type 1 (AT1) receptors contributes to the development of hypertension in diabetes.
|
28842434 |
2017 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Although the octapeptide hormone angiotensin II (Ang II) regulates cardiovascular and renal homeostasis through the Ang II type 1 receptor (AT1R), overstimulation of AT1R causes various human diseases, such as hypertension and cardiac hypertrophy.
|
28648738 |
2017 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
More importantly, we showed for the first time that oral administration of azilsartan, a newly developed AT1R blocker approved by the U.S. Food and Drug Administration for hypertension treatment, rescued the apoptosis of dopaminergic neurons and relieved the characteristic parkinsonian symptoms in PD rats.
|
28445961 |
2017 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
These responses do not require the presence of concurrent AT1R blockade and are effective both in the prevention and reversal of hypertension.
|
27664954 |
2017 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Losartan is a selective antagonist of AngⅠ type (AT1) receptor of Angiotensin Ⅱ (Ang Ⅱ), which is widely used as a clinical medicine for the hypertension.
|
28483563 |
2017 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Areas covered: In this review we aimed at examining a variety of drugs (statins, beta-adrenergic receptor blockers, calcium channel blockers, angiotensin converting enzyme inhibitors, angiotensin II type-1 receptor blockers) used to treat hypertension and other cardiovascular diseases, particularly with respect to their potential of increasing NO bioavailability and activity in the cardiovascular system.
|
28338370 |
2017 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Despite upregulation of AT1R and P2X1R in hypertension, Up4A-mediated aortic contraction was impaired in Ang II-infused mice, likely through the desensitization of P2X1R but not AT1R.
|
28034895 |
2017 |