|
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
In conclusion, the diminished angiotensin II vasoconstriction with age in heart failure patients is most likely due to a lower density of AT(1) receptors and may result from a longer period of exposure to heart failure in older patients.
|
15569271 |
2004 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
PVN microinjection of PKCγ siRNA had the same effect on LOS above responses to hypertension but no effect on PVN level of AT1R.
|
28338001 |
2017 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Thus, we concluded that AT1 pathway plays a role in pulmonary vascular dysfunction by increasing oxidative stress and reducing NO bioavailability, thereby contributing to vascular remodeling and pulmonary hypertension of iron-overload.
|
29990562 |
2018 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Since Hap-I of the human AT1R gene is associated with hypertension in Caucasians, we generated transgenic (TG) mice with Hap-I and Hap-II and studied the physiological significance of high fat diet (HFD) on haplotype specific gene expression.
|
29036458 |
2018 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
These results suggest that the AGT and AT1 receptor genes are not major genetic determinants of hypertension associated with NIDDM in this population, although we can not exclude the possibility that these loci make a minor contribution in a polygenic context.
|
9218178 |
1997 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
AT1R antibody was associated with renal allograft loss (odds ratio of 13.1 [95% confidence interval 1.48-1728]), the presence of glomerulitis or arteritis, and significantly higher TNF-α, IL-1β, and IL-8 levels, but not rejection or hypertension.
|
28927645 |
2018 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
New results have been obtained on the possible role of the angiotensinogen gene, and other candidate genes, such as the angiotensin II receptor Type I gene and the Sa gene, in human hypertension.
|
7600049 |
1995 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
These data suggest that the (-535)T allele of AGTR1 and (-344)T allele of CYP11B2 may increase hypertension risk among African Americans but not among Latinos.
|
15545843 |
2004 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Angiotensin II and its type 1 receptor (AT1R) are both expressed in the adipose tissue and involved in the genesis of atherosclerosis as well as hypertension.
|
19696781 |
2009 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Our study pooled previous findings and showed that the AT1R +1166 C allele conferred an increased risk of hypertension.
|
20703234 |
2010 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
The estimated effect implied that AGTR1 may have a protective effect for hypertension.
|
28381821 |
2017 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
The uremic environment seems to dominate over previously reported actions of high blood pressure and cholesterol to enhance leukocyte Angiotensin II AT1 receptor expression.
|
21640098 |
2011 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
There are reported associations between an angiotensin II type I receptor gene polymorphism (AT(1)R/A1166C) with hypertension, myocardial infarction, insulin resistance and cardiovascular disease risk.
|
20851291 |
2010 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Blockers of angiotensin II type 1 receptor (AT<sub>1</sub>R) and the voltage gated calcium channel 1.2 (Ca<sub>V</sub>1.2) are commonly used for treatment of hypertension.
|
28514967 |
2017 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Therefore, we conducted an association study between A1166C variants of the AT1 receptor gene and hypertension in the Japanese population.
|
12627871 |
2003 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
In the present work, the role of angiotensin II type 1-receptor (AGTR1) gene polymorphisms as susceptibility markers for hypertension was evaluated.
|
21846682 |
2012 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
To explore the roles of glutamate acid decarboxylase 65 (GAD65) and angiotensin II type 1 receptor (AT<sub>1</sub>R) in the action of renal sympathetic denervation (RSD) on obesity-induced hypertension in canines.
|
29172730 |
2018 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
However, no influence of ACE and AT1R polymorphisms on left ventricular mass was found, regardless of systemic hypertension.
|
9227291 |
1997 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
We hypothesized that enhanced constrictive responsiveness of renal afferent arterioles (Af-Art) to angiotensin II (ANG II) mediated by ANG II type 1 (AT1) receptors contributes to the development of hypertension in diabetes.
|
28842434 |
2017 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Renal AT1R was found to be primarily responsible for Ang II-mediated hypertension.
|
30061705 |
2018 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
To investigate the association of polymorphism in the angiotensin-converting enzyme (ACE) I/D gene, angiotensinogen M235T gene, and angiotensin II type 1 receptor A1166C gene with body mass index, body fat pattern, and obesity-associated hypertension.
|
12513040 |
2003 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Although the octapeptide hormone angiotensin II (Ang II) regulates cardiovascular and renal homeostasis through the Ang II type 1 receptor (AT1R), overstimulation of AT1R causes various human diseases, such as hypertension and cardiac hypertrophy.
|
28648738 |
2017 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Intranasal immunization with AT1R-PspA vaccine has the potential to simultaneously attenuate the development of hypertension and protect from lethal pneumococcal infection.
|
28832363 |
2018 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
More importantly, we showed for the first time that oral administration of azilsartan, a newly developed AT1R blocker approved by the U.S. Food and Drug Administration for hypertension treatment, rescued the apoptosis of dopaminergic neurons and relieved the characteristic parkinsonian symptoms in PD rats.
|
28445961 |
2017 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
We investigated the associations between hypertension status and the genotypes of four single nucleotide polymorphism (SNP) sites in four hypertension-related genes (Angiotensinogen [AGT], Angiotensin I Converting Enzyme [ACE], Angiotensinogen II receptor, subtype 1 [AGTR1], and Alpha 1-Antichymotrypsin [ACT or SERPINA3]), in an African American sample.
|
19341158 |
2009 |