|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Responses of blood vessels to endothelin-1 may be normal or depressed in many models of experimental hypertension and also in essential hypertension in humans.
|
7768553 |
1995 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Contractile responses of renal arteries to Ang II, endothelin-1 (ET-1), and NA were decreased in dTGR, suggesting hypertension-associated generalized changes in the vascular function rather than a receptor-specific desensitization.
|
11230310 |
2001 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Endothelin-1 (ET-1) is a powerful vasoconstrictor peptide considered to be causally implicated in hypertension and the development of cardiovascular disease.
|
31630572 |
2019 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Endothelin-1 (ET-1), as it functions as a neuromodulator, has been associated with hypertension in chronic intermittent hypoxia (CIH) which attribute to enhanced carotid body sensibility to hypoxia.
|
30579678 |
2019 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Finally, we suggest that these observations may help to explain why patients with pulmonary hypertension experience exacerbations after taking indomethacin and that the newly introduced selective cyclooxygenase-2 inhibitors may increase endothelin-1 production in susceptible patients, leading to vascular remodeling and the development of pulmonary hypertension.
|
12391278 |
2002 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
The objective of the investigation was to assess whether circulating adhesion molecules, von Willebrand factor (vWf) and endothelin-1 are elevated in patients with mild uncomplicated essential hypertension without further risk factors of atherosclerosis and whether they could serve as indicators of endothelial dysfunction in this form of hypertension.
|
12425201 |
2002 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
LHGDN |
In summary, our results uncover a sex-specific protective effect of variation in the ET-1 gene on the progression of hypertension risk, and a SES-specific effect on risk of developing left ventricular hypertrophy in multiethnic youth.
|
15505112 |
2004 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The endothelin-1 G5665T single nucleotide polymorphism has been linked to increased vascular reactivity and hypertension.
|
18603063 |
2008 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
AAV vector-mediated CRP expression resulted in hypertension mediated through reduced NO production and subsequent alteration in ET-1 and renin-angiotensin system activation.
|
19056836 |
2009 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Given the negative vascular effects of ET-1, this abnormality may contribute to the pathogenesis of hypertension and its complications in black patients.
|
15148269 |
2004 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Pentaerythritol Tetranitrate In Vivo Treatment Improves Oxidative Stress and Vascular Dysfunction by Suppression of Endothelin-1 Signaling in Monocrotaline-Induced Pulmonary Hypertension.
|
28337251 |
2017 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
We assessed the role of endothelin-1, acting through endothelin A (ET<sub>A</sub> ) receptors, in modulating the central and peripheral cardiovascular responses to exercise in patients with hypertension via local antagonism of these receptors during exercise.
|
31705661 |
2020 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
The most potent vasoconstrictor, endothelin-1 and its receptors, endothelin receptor A (EDNRA) and endothelin receptor B (EDNRB) are involved in hypertension.
|
31150867 |
2019 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
LHGDN |
They also demonstrate that enhancement of the expression of endothelin-1 gene in blood vessels and in the heart of hypertensive rats may occur in the absence of exposure to DOCA and salt, and that endothelin-1 gene overexpression in experimental hypertension occurs early in non-renin-dependent, volume-expanded models such as the one-kidney, one clip or the DOCA-salt hypertensive rat, but only in the progressively non-renin-dependent late phase of the initially renin-dependent volume-contracted two-kidney, one clip hypertensive rat.
|
12013496 |
1996 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
These findings highlight the role of endothelin-1 in driving biventricular remodeling secondary to RV hypertension and suggest that early therapy with an endothelin-1 receptor blocker may be beneficial in attenuating biventricular remodeling but that late therapy is also effective.
|
29446710 |
2018 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Endothelin 1 type a receptor antagonism prevents vascular dysfunction and hypertension induced by 11beta-hydroxysteroid dehydrogenase inhibition: role of nitric oxide.
|
11425780 |
2001 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
It is believed that ET-1 plays an important role in pathogenesis of hypertension, and cardiovascular diseases; therefore, research in order to limit ET-1-mediated action is still in progress.
|
29738719 |
2018 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Magnesium attenuates endothelin-1-induced vasoreactivity and enhances vasodilatation in mouse pulmonary arteries: Modulation by chronic hypoxic pulmonary hypertension.
|
29363240 |
2018 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The associations of the 5-HT2A T102C polymorphism with hypertension and diastolic blood pressure in ET-1 T allele carriers were significant (p = 0.0056 and 0.021, respectively).
|
16778329 |
2006 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
There is much evidence to suggest that endothelin-1 might be involved in the pathogenesis of hypertension, atherosclerosis, and ischemic heart disease.
|
10192234 |
1999 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Investigating the association between K198N coding polymorphism in EDN1 and hypertension, lipoprotein levels, the metabolic syndrome and cardiovascular disease.
|
18288492 |
2008 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Studies suggest that endothelin-1 contributes to the pathogenesis of hypertension.
|
15188945 |
2004 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
No study has yet determined the impact of this polymorphism on vascular reactivity, although a functional role for endothelin-1 in the pathophysiology of hypertension has been clarified.
|
11847185 |
2002 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Ambrisentan is a highly selective endothelin-1 type A receptor antagonist indicated for use in the treatment of pulmonary hypertension.
|
29289894 |
2018 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
HLA-B35 upregulates the production of endothelin-1 in HLA-transfected cells: a possible pathogenetic role in pulmonary hypertension.
|
16948645 |
2006 |