|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Review of the GDB [Human Genome Database, 1990] reveals that the duplicated region includes the locus EDN2 that encodes endothelin-1, a potent vasoconstrictor, making genetic overdosage of this protein a likely etiology of the pulmonary hypertension.
|
11391651 |
2001 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Mφ and ET-1 may play an important role in BP control and potentially have a critical role as a therapeutic target in hypertension.
|
30657897 |
2019 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Our findings define novel molecular mechanism involving interplay between microparticles, the ET-1 system and endothelial cell pro-inflammatory and redox signalling, which may be important in cardiovascular toxicity and hypertension associated with VEGFi anti-cancer treatment.
|
30753341 |
2019 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Potent and selective non-peptidic inhibitors of endothelin-converting enzyme-1 with sustained duration of action.
|
10669576 |
2000 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
CD ET-1 KO mice on a high-Na diet had worsened hypertension, reduced urinary Na excretion, and excessive weight gain, but showed no differences between aldosterone excretion and plasma renin activity.
|
15314687 |
2004 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
In view of the multiple cardiovascular actions of endothelin-1, there has been much interest in its contribution to the pathophysiology of hypertension.
|
9794709 |
1998 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
The aim of this study was to investigate if hypertension has an effect on vasoconstrictive receptor responses to endothelin 1, sarafotoxin 6c and angiotensin II after stroke by inducing transient middle cerebral artery occlusion in spontaneously hypertensive rats and Wistar-Kyoto rats using the wire-myograph.
|
29190633 |
2018 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
The angiotensin II AT<sub>1</sub> and the endothelin 1 ET<sub>A</sub> receptors play a crucial role in the pathogenesis of cardiovascular diseases like hypertension, heart failure, stroke, pulmonary hypertension, and cardiac hypertrophy.
|
30851407 |
2019 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Thus, loss of ET-1-dependent natriuresis may account for sodium retention during stress and may predispose retainers to renal diseases such as hypertension and kidney disease.
|
29246686 |
2018 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1.
|
8152482 |
1994 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The purpose of this study was to investigate the role of endothelin-1 Lys198Asn polymorphism in patients with severe arterial hypertension as well as associated endorgan damages.
|
18923236 |
2008 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Endothelin-1 (ET-1) is a potential contributor to sex differences in the pathophysiology of hypertension.
|
30606254 |
2019 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Experimental studies and clinical trials have demonstrated that ET-1 plays a major role in normal cardiovascular homeostasis and in the functional and structural changes observed in arterial and pulmonary hypertension, glomerulosclerosis, atherosclerosis, and heart failure.
|
16855133 |
2006 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
The goal of this study is to elucidate the role of Endothelin-1 (ET-1) in aortic stiffening-induced hypertension through ET<sub>A</sub> receptor activation.
|
29449619 |
2018 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
We therefore looked for irET-1 in the different layers of the wall of human arteries, including renal, gastric, and internal thoracic artery wall, obtained ex vivo from consenting patients with coronary artery disease and/or high blood pressure undergoing surgery, as well as from young organ donors.
|
10069781 |
1999 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
These results illuminate a novel mechanistic pathway linking hemolysis and erythroid hyperplasia to increased PlGF, endothelin-1, and pulmonary hypertension in SCD, and suggest that strategies that block PlGF signaling may be therapeutically beneficial.
|
20335221 |
2010 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Olmesartan improves endothelin-induced hypertension and oxidative stress in rats.
|
15302986 |
2004 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
This resulted in a rapid onset of hypertension, a decrease in eNOS expression, and an increase in endothelin-1 plasma levels, with all mice dying within 5 wk.
|
31196980 |
2019 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
RGD |
Hypertension induced by the tyrosine kinase inhibitor sunitinib is associated with increased circulating endothelin-1 levels.
|
20733093 |
2010 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
We assessed the correlation of 10 single-nucleotide polymorphisms (SNPs) in genes modulating angiogenesis (vascular endothelial growth factor-A (VEGF-A), VEGF receptor 1 (VEGFR-1), serine threonine kinase 39 (STK39)) or hypertension (endothelin-1 and uromodulin) with outcome and toxicity.
|
27139155 |
2017 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
The present study was designed to test the hypothesis that VEGF receptor inhibitor treatment leads to hypertension through decreased renal medullary formation of NO and endothelin-1.
|
29311252 |
2018 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Endothelin-1 increases vascular superoxide via endothelin(A)-NADPH oxidase pathway in low-renin hypertension.
|
12600921 |
2003 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Increased pulmonary and LV expression of preproET-1 suggests that ET-1 plays a role in mediating the pulmonary hypertension and LV dysfunction characteristic of this model.
|
9595502 |
1998 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Patients with uncomplicated hypertension with no other risk factors of atherosclerosis had significantly elevated levels of ICAM-1, vWf, and endothelin-1.
|
12149661 |
2002 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Endothelin-1/nitric oxide balance and HOMA index in children with excess weight and hypertension: a pathophysiological model of hypertension.
|
30923371 |
2019 |