|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our previous report revealed that <i>Drynaria fortunei</i> (Polydiaceae) protected against 6-hydroxydopamine (6-OHDA)-induced oxidative damage via the PI3K/AKT pathway in B35 neuroblastoma cells.
|
30301204 |
2018 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study we investigated the phosphorylation status of key proteins in the PI3K/AKT/mTOR pathway and the effects of the mTOR inhibitors rapamycin and CCI-779 on neuroblastoma tumorigenesis.
|
18026138 |
2008 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, PI3K/AKT-dependent oncogenic transformations require N-myc, an extensively studied oncogene in neuroblastoma.
|
23468863 |
2013 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Proximity ligation and two-way immunoprecipitation assays using monoclonal antibodies against gB and Akt-1 phosphorylated at S473 [Akt-1(S473)] confirmed that HSV-1(McKrae) gB interacted with Akt-1(S473) during virus entry into human neuroblastoma (SK-N-SH) cells and induced the release of intracellular calcium.
|
29321326 |
2018 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study was aimed to explore the neuroprotective effect of AA against aluminium maltolate <b>(</b>Al(mal)<sub>3</sub>) induced neurotoxicity by assessing cell viability, mitochondrial membrane potential, levels of reactive oxygen species (ROS), DNA damage and apoptosis (Hoechst and dual staining, comet assay; expressions of pro-apoptotic, anti-apoptotic and signaling indices) via AKT/GSK-3β signaling pathway in SH-SY 5Y neuroblastoma cells.
|
28930619 |
2018 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
BCH motif-containing molecule at the carboxyl terminal region 1 (BMCC1)/PRUNE2 is highly expressed in patients with favorable neuroblastoma (NB), encoding a multifunctional scaffold protein that modulates several signaling networks including RhoA and AKT pathways.
|
27453342 |
2016 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, whole-genome transcriptome analysis revealed that BRG1 controls the expression of key elements of oncogenic pathways such as PI3K/AKT and BCL2, which offers a promising new combination therapy for high-risk NB.
|
26996667 |
2016 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In summary, we found NLGN3 promoted neuroblastoma cell proliferation and growth through activating PI3K/AKT pathway and providing a new target for neuroblastoma therapy.
|
31150649 |
2019 |
|
Neuroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Reduction of Akt1 phosphorylation and apoptosis resistance were also evident when a neuroblastoma SH-SY5Y clone overexpressing WT LRRK2 was transfected with the I2020T LRRK2.
|
23220480 |
2013 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib in ALK-mutated neuroblastoma.
|
25228590 |
2014 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2, and c-Myc pathways.
|
21993994 |
2012 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This growth effect was accompanied by a marked decrease in the expression of MYC, MYCN, AKT and an increase in p53 expression in neuroblastoma cell lines without TP53 mutation.
|
24173829 |
2014 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Activation of PI3K/AKT survival pathway may contribute to the increased drug resistance in TrkB-expressing neuroblastomas.
|
12438236 |
2002 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A decrease in the ratio of PTEN to phospho-Akt protein expression was identified in poorly differentiated neuroblastomas.
|
15849504 |
2005 |
|
Neuroblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
In contrast to RAS-MAPK pathway-mutated neuroblastoma cell lines, ALK-addicted neuroblastoma cells treated with trametinib showed increased activation (inferred by phosphorylation) of the kinases AKT and ERK5.
|
29184034 |
2017 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we report that membrane depolarization triggered IKC intracellular signals mediated by small GTPases of the Ras subfamily and protein kinase B (Akt) to advance the development of filopodia and lamellipodia in Chinese hamster ovary cells, stimulate their motility, and enhance neurite outgrowth in mouse neuroblastoma Neuro2a cells.
|
31682765 |
2019 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inactivation of FOXO3a by AKT was essential for neuroblastoma cell survival.
|
23378341 |
2013 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Activation of the PI3K target AKT is frequent in neuroblastoma (NB) and correlates with poor prognosis.
|
25622909 |
2015 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Afatinib also induced apoptosis and blocked EGF-induced activation of PI3K/AKT/mTOR signaling in all neuroblastoma cell lines tested.
|
27902463 |
2017 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we measured the expression level of GIGYF1, Grb10, phosphorylated IGF1R/IGF1R, phosphorylated AKT serine/threonine protein kinase/protein kinase B (AKT)/AKT, and phosphorylated extracellular signal-regulated kinase (ERK)/ERK in human neuroblastoma SHSY-5Y cells.
|
30376373 |
2018 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We then demonstrate that the uptake of NB exosomes by MSCs was associated with a rapid increase in ERK1/2 and AKT activation, and that blocking ERK1/2 but not AKT activation inhibited the IL-6 and IL-8/CXCL8 production by MSCs without affecting exosome uptake.
|
28717423 |
2017 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PAG1 knockdown in NB cells promotes proliferation and anchorage-independent colony formation with increased activation of AKT and ERK downstream of c-Src, while PAG1 overexpression significantly rescues these effects.
|
26993602 |
2016 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that repression of Survivin by FKHRL1 facilitates FKHRL1-induced apoptosis and sensitizes to cell death induced by DNA-damaging agents, which supports the central role of PI3K-PKB-FKHRL1 signaling in drug resistance of human NB.
|
19211844 |
2009 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The way of PI3K/AKT/mTOR pathway activation in neuroblastoma (NB) is not well established.
|
21225506 |
2010 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Myr-AKT overexpression reversed SPARC-mediated PTEN and increased proliferation of neuroblastoma cells in vitro.
|
22567126 |
2012 |