AKT1, AKT serine/threonine kinase 1, 207

N. diseases: 1250; N. variants: 33
Disease: Neuroblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.100 Biomarker disease BEFREE CD133 expression is associated with poor outcome in neuroblastoma via chemoresistance mediated by the AKT pathway. 22394107 2012
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.100 AlteredExpression disease BEFREE Furthermore, activation of AKT (pAKT) positively correlated with neuroblastoma progression in an in vivo tumor-metastasis model. 24039782 2013
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.100 Biomarker disease BEFREE The detected variants are located within the different domains of TIAM1 that signal to the upstream regulator RAS and downstream effector molecules MYC and RAC, which are all implicated in neuroblastoma etiology and progression. 28423360 2017
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.100 Biomarker disease BEFREE We have previously demonstrated an increased expression of gastrin-releasing peptide (GRP) and its receptor, GRPR, in neuroblastoma and that GRP activates the PI3K-AKT pathway as a proangiogenic factor during tumor progression. 24108003 2013
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.100 Biomarker disease BEFREE SD also inhibited AKT activation in neuroblastoma cells as shown by reduced phosphorylated AKT levels. 29335887 2018
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.100 Biomarker disease BEFREE We examined epidermal growth factor receptor (EGFR), Kirsten rate sarcoma viral oncogene homolog (KRAS), v-Raf murine sarcoma viral oncogene homolog B1 (BRAF), human epidermal growth factor receptor 2 (HER2), PIK3CA, v-akt murine thymoma vial oncogene homolog 1 (AKT1), v-ras neuroblastoma viral oncogene homolog (NRAS), dual specificity mitogen-activated protein kinase kinase 1 (MEK1), and anaplastic lymphoma kinase (ALK) in patients with adenocarcinoma of the lung to identify driver mutations. 22135231 2012
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.100 PosttranslationalModification disease BEFREE Perifosine, at 30 muM concentration, decreased AKT phosphorylation and increased apoptosis in all four NB cell lines in vitro. 20463309 2010