Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In summary, we found NLGN3 promoted neuroblastoma cell proliferation and growth through activating PI3K/AKT pathway and providing a new target for neuroblastoma therapy.
|
31150649 |
2019 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we report that membrane depolarization triggered IKC intracellular signals mediated by small GTPases of the Ras subfamily and protein kinase B (Akt) to advance the development of filopodia and lamellipodia in Chinese hamster ovary cells, stimulate their motility, and enhance neurite outgrowth in mouse neuroblastoma Neuro2a cells.
|
31682765 |
2019 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our previous report revealed that <i>Drynaria fortunei</i> (Polydiaceae) protected against 6-hydroxydopamine (6-OHDA)-induced oxidative damage via the PI3K/AKT pathway in B35 neuroblastoma cells.
|
30301204 |
2018 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Proximity ligation and two-way immunoprecipitation assays using monoclonal antibodies against gB and Akt-1 phosphorylated at S473 [Akt-1(S473)] confirmed that HSV-1(McKrae) gB interacted with Akt-1(S473) during virus entry into human neuroblastoma (SK-N-SH) cells and induced the release of intracellular calcium.
|
29321326 |
2018 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study was aimed to explore the neuroprotective effect of AA against aluminium maltolate <b>(</b>Al(mal)<sub>3</sub>) induced neurotoxicity by assessing cell viability, mitochondrial membrane potential, levels of reactive oxygen species (ROS), DNA damage and apoptosis (Hoechst and dual staining, comet assay; expressions of pro-apoptotic, anti-apoptotic and signaling indices) via AKT/GSK-3β signaling pathway in SH-SY 5Y neuroblastoma cells.
|
28930619 |
2018 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we measured the expression level of GIGYF1, Grb10, phosphorylated IGF1R/IGF1R, phosphorylated AKT serine/threonine protein kinase/protein kinase B (AKT)/AKT, and phosphorylated extracellular signal-regulated kinase (ERK)/ERK in human neuroblastoma SHSY-5Y cells.
|
30376373 |
2018 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
SD also inhibited AKT activation in neuroblastoma cells as shown by reduced phosphorylated AKT levels.
|
29335887 |
2018 |
Neuroblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
In contrast to RAS-MAPK pathway-mutated neuroblastoma cell lines, ALK-addicted neuroblastoma cells treated with trametinib showed increased activation (inferred by phosphorylation) of the kinases AKT and ERK5.
|
29184034 |
2017 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Afatinib also induced apoptosis and blocked EGF-induced activation of PI3K/AKT/mTOR signaling in all neuroblastoma cell lines tested.
|
27902463 |
2017 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We then demonstrate that the uptake of NB exosomes by MSCs was associated with a rapid increase in ERK1/2 and AKT activation, and that blocking ERK1/2 but not AKT activation inhibited the IL-6 and IL-8/CXCL8 production by MSCs without affecting exosome uptake.
|
28717423 |
2017 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The detected variants are located within the different domains of TIAM1 that signal to the upstream regulator RAS and downstream effector molecules MYC and RAC, which are all implicated in neuroblastoma etiology and progression.
|
28423360 |
2017 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
BCH motif-containing molecule at the carboxyl terminal region 1 (BMCC1)/PRUNE2 is highly expressed in patients with favorable neuroblastoma (NB), encoding a multifunctional scaffold protein that modulates several signaling networks including RhoA and AKT pathways.
|
27453342 |
2016 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, whole-genome transcriptome analysis revealed that BRG1 controls the expression of key elements of oncogenic pathways such as PI3K/AKT and BCL2, which offers a promising new combination therapy for high-risk NB.
|
26996667 |
2016 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PAG1 knockdown in NB cells promotes proliferation and anchorage-independent colony formation with increased activation of AKT and ERK downstream of c-Src, while PAG1 overexpression significantly rescues these effects.
|
26993602 |
2016 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Activation of the PI3K target AKT is frequent in neuroblastoma (NB) and correlates with poor prognosis.
|
25622909 |
2015 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib in ALK-mutated neuroblastoma.
|
25228590 |
2014 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This growth effect was accompanied by a marked decrease in the expression of MYC, MYCN, AKT and an increase in p53 expression in neuroblastoma cell lines without TP53 mutation.
|
24173829 |
2014 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, PI3K/AKT-dependent oncogenic transformations require N-myc, an extensively studied oncogene in neuroblastoma.
|
23468863 |
2013 |
Neuroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Reduction of Akt1 phosphorylation and apoptosis resistance were also evident when a neuroblastoma SH-SY5Y clone overexpressing WT LRRK2 was transfected with the I2020T LRRK2.
|
23220480 |
2013 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inactivation of FOXO3a by AKT was essential for neuroblastoma cell survival.
|
23378341 |
2013 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, activation of AKT (pAKT) positively correlated with neuroblastoma progression in an in vivo tumor-metastasis model.
|
24039782 |
2013 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have previously demonstrated an increased expression of gastrin-releasing peptide (GRP) and its receptor, GRPR, in neuroblastoma and that GRP activates the PI3K-AKT pathway as a proangiogenic factor during tumor progression.
|
24108003 |
2013 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
AKT (v-akt murine thymoma viral oncogene homolog 1) and N-Ras (neuroblastoma ras viral oncogene homolog) coactivation in the mouse liver promotes rapid carcinogenesis by way of mTOR (mammalian target of rapamycin complex 1), FOXM1 (forkhead box M1)/SKP2, and c-Myc pathways.
|
21993994 |
2012 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Myr-AKT overexpression reversed SPARC-mediated PTEN and increased proliferation of neuroblastoma cells in vitro.
|
22567126 |
2012 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CD133 expression is associated with poor outcome in neuroblastoma via chemoresistance mediated by the AKT pathway.
|
22394107 |
2012 |