AKT1, AKT serine/threonine kinase 1, 207

N. diseases: 1250; N. variants: 33
Disease: Neuroblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.100 PosttranslationalModification disease BEFREE Perifosine, at 30 muM concentration, decreased AKT phosphorylation and increased apoptosis in all four NB cell lines in vitro. 20463309 2010
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.100 AlteredExpression disease BEFREE This growth effect was accompanied by a marked decrease in the expression of MYC, MYCN, AKT and an increase in p53 expression in neuroblastoma cell lines without TP53 mutation. 24173829 2014
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.100 AlteredExpression disease BEFREE A decrease in the ratio of PTEN to phospho-Akt protein expression was identified in poorly differentiated neuroblastomas. 15849504 2005
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.100 AlteredExpression disease BEFREE Afatinib also induced apoptosis and blocked EGF-induced activation of PI3K/AKT/mTOR signaling in all neuroblastoma cell lines tested. 27902463 2017
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.100 AlteredExpression disease BEFREE PAG1 knockdown in NB cells promotes proliferation and anchorage-independent colony formation with increased activation of AKT and ERK downstream of c-Src, while PAG1 overexpression significantly rescues these effects. 26993602 2016
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.100 AlteredExpression disease BEFREE Myr-AKT overexpression reversed SPARC-mediated PTEN and increased proliferation of neuroblastoma cells in vitro. 22567126 2012
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.100 AlteredExpression disease BEFREE Furthermore, activation of AKT (pAKT) positively correlated with neuroblastoma progression in an in vivo tumor-metastasis model. 24039782 2013