Uterine Fibroids
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The purpose of this study was to analyze the effect of ERα-351 XbaI A/G, ERα-397 PvuII T/C, and progesterone receptor (PGR) PROGINS polymorphisms on the development of leiomyomas.
|
30390345 |
2019 |
Uterine Fibroids
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In the present study, by evaluating G protein-coupled estrogen receptor (GPER), ERα36, and phospho-epidermal growth factor receptor (EGFR) expression in human tissues, we found that GPER, ERα36 and phospho-EGFR were all highly expressed in fibroids compared to patient-matched myometrial tissues.
|
31468104 |
2019 |
Uterine Fibroids
|
0.400 |
Biomarker
|
group |
BEFREE |
It highlights the difficulty in classifying some gastrointestinal SMNs as either LMs or LMSs and the importance of ER status in SMNs.
|
30431607 |
2018 |
Uterine Fibroids
|
0.400 |
Biomarker
|
group |
BEFREE |
To study the transforming growth factor beta (TGF-β) signaling pathway in interactions with estrogen receptor alpha (ERα) signaling pathway mediating the growth of human uterine leiomyoma (UL) activated by phenolic environmental estrogens (EEs).
|
29970676 |
2018 |
Uterine Fibroids
|
0.400 |
Biomarker
|
group |
BEFREE |
ERα inhibited myocardin-induced differentiation in uterine fibroids.
|
27871850 |
2017 |
Uterine Fibroids
|
0.400 |
Biomarker
|
group |
BEFREE |
Transthoracic needle biopsy was performed and the resected lesion consisted of benign spindle cells was positive for estrogen receptor (ER) and progesterone receptor (PR) and was diffuse positive for actin and desmin by immunohistochemical (IHC) staining, suggesting leiomyoma.
|
28203428 |
2017 |
Uterine Fibroids
|
0.400 |
Biomarker
|
group |
BEFREE |
ER-alpha, ER-beta, and PR proteins were also higher in leiomyomas and the level of these proteins negatively correlated with the level of 14-3-3 gamma protein.
|
27100507 |
2016 |
Uterine Fibroids
|
0.400 |
Biomarker
|
group |
BEFREE |
Estrogen stimulates cell proliferation through binding to the estrogen receptor (ER), of which both subtypes α and β are present in leiomyomas.
|
26529545 |
2016 |
Uterine Fibroids
|
0.400 |
Biomarker
|
group |
BEFREE |
One extrauterine, retroperitoneal estrogen receptor-positive leiomyoma was also FH deficient.
|
27454940 |
2016 |
Uterine Fibroids
|
0.400 |
Biomarker
|
group |
BEFREE |
A specific category of leiomyomas are estrogen-receptor positive ones in women.
|
24384850 |
2014 |
Uterine Fibroids
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The PvuII polymorphism in the ER-α gene may be a risk factor for ULM.
|
23749503 |
2013 |
Uterine Fibroids
|
0.400 |
Biomarker
|
group |
BEFREE |
Previously, we reported that fenvalerate (Fen) promotes proliferation of human uterine leiomyoma (UtLM) cells by enhancing progression of cells from G(0)-G(1) to S phase through molecular mechanisms independent of estrogen receptor-α and -β.
|
22850687 |
2012 |
Uterine Fibroids
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The protein expression of ERα, ERβ and aromatase was similar in leiomyoma and normal myometrium (p = 0.239, p = 0.695 and p = 0.203, respectively).
|
22377971 |
2012 |
Uterine Fibroids
|
0.400 |
Biomarker
|
group |
BEFREE |
The spearman's rho (ρ) was .53 (P = .008) between HDAC6 and ERα in normal myometrium and, more significantly, the spearman rho was .80 (P < .001) between HDAC6 and ERα in leiomyoma.
|
21421902 |
2011 |
Uterine Fibroids
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A T/C SNP in intron 1 and exon 2 boundary of estrogen receptor (ER) alpha gene recognized by PvuII enzyme has been associated with several female pathologies like breast cancer, osteoporosis, endometriosis and fibroids in various ethnic groups.
|
19729795 |
2009 |
Uterine Fibroids
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Estrogen receptor subtype alpha mRNA levels were significantly, and 1.8- to 2.6-fold, higher in leiomyoma compared with adjacent myometrium in all groups, whereas leiomyoma estrogen receptor subtype beta mRNA levels were significantly elevated only in Japanese women.
|
19240151 |
2009 |
Uterine Fibroids
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The level of messenger RNA expression of estrogen receptor alpha and beta and the level of estrogen receptor as a whole are increased on average to a similar extent in leiomyomas compared with normal myometrium.
|
18166184 |
2008 |
Uterine Fibroids
|
0.400 |
Biomarker
|
group |
CTD_human |
In conclusion, there was an aberrant DNA methylation status in the promoter region of ER-alpha gene in uterine leiomyoma, which may be associated with high ER-alpha mRNA expression.
|
18701604 |
2008 |
Uterine Fibroids
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The expression of estrogen receptor isoforms alpha, beta and insulin-like growth factor-I in uterine leiomyoma.
|
19012097 |
2008 |
Uterine Fibroids
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In conclusion, there was an aberrant DNA methylation status in the promoter region of ER-alpha gene in uterine leiomyoma, which may be associated with high ER-alpha mRNA expression.
|
18701604 |
2008 |
Uterine Fibroids
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We aimed to elucidate the association of estrogen receptor alpha (ERalpha)-351 A>G (XbaI) and -397 T>C (PvuII) gene polymorphisms with endometriosis and leiomyoma.
|
17121748 |
2007 |
Uterine Fibroids
|
0.400 |
Biomarker
|
group |
BEFREE |
Furthermore, our findings provided little support for the association of these SNPs on ESR1 with leiomyoma.
|
16935316 |
2006 |
Uterine Fibroids
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Carriage of the ESR1 IVS1-397 T/C (PvuII), COMT G158A, and the CYP17A 34T-->C SNPs is not associated with the susceptibility to uterine leiomyoma in a Caucasian population.
|
16595228 |
2006 |
Uterine Fibroids
|
0.400 |
Biomarker
|
group |
BEFREE |
Our in vivo data in a mouse model demonstrate the ability of an adenovirus-expressing dominant-negative ER to arrest leiomyoma growth.
|
16603566 |
2006 |
Uterine Fibroids
|
0.400 |
Biomarker
|
group |
BEFREE |
In all cases, pulmonary tumors had benign histology and immunohistochemical profiles (estrogen receptor positive, progesterone receptor positive, and very low proliferative index) identical to uterine leiomyoma.
|
16357844 |
2006 |