Uterine Fibroids
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Ethnic distribution of estrogen receptor-alpha polymorphism is associated with a higher prevalence of uterine leiomyomas in black Americans.
|
16860797 |
2006 |
Uterine Fibroids
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Estrogen receptor-alpha expression in endometrium was lower than in leiomyomas and myometrium.
|
15474102 |
2004 |
Uterine Fibroids
|
0.400 |
Biomarker
|
group |
BEFREE |
Dominant-negative estrogen receptor gene therapy may provide a nonsurgical treatment option for women with symptomatic uterine fibroids who want to preserve their uteri.
|
15547533 |
2004 |
Uterine Fibroids
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Estrogen receptor thymine-adenine dinucleotide repeat polymorphism is associated with susceptibility to leiomyoma.
|
12524070 |
2003 |
Uterine Fibroids
|
0.400 |
Biomarker
|
group |
BEFREE |
Analysis of estrogen receptor (ERalpha and ERbeta) and progesterone receptor (PR) polymorphisms in uterine leiomyomas.
|
12552233 |
2003 |
Uterine Fibroids
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Analysis of cells for estrogen receptor-alpha and progesterone receptor proteins by Western blotting showed no change in expression of these proteins between the immortalized and parental leiomyoma and myometrial cells.
|
12065682 |
2002 |
Uterine Fibroids
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Estrogen receptor-alpha and -beta expression in microvascular endothelial cells and smooth muscle cells of myometrium and leiomyoma.
|
12149410 |
2002 |
Uterine Fibroids
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The Pvu II and Xba I polymorphisms in the ER-alpha gene do not produce different risks of developing uterine leiomyomas.
|
11239543 |
2001 |
Uterine Fibroids
|
0.400 |
Biomarker
|
group |
BEFREE |
The present results imply that the increased ratio of ER alpha/ER beta observed in the fibroids after GnRHa treatment could reflect or be the cause of the shrinkage of the leiomyoma, which is the clinical outcome of this treatment.
|
11826769 |
2001 |
Uterine Fibroids
|
0.400 |
AlteredExpression
|
group |
BEFREE |
On the other hand, estrogen receptor-alpha (ER-alpha) mRNA is hyper-expressed in 67% of the leiomyomas as compared to their paired myometrium.
|
11232041 |
2001 |
Uterine Fibroids
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Paradoxically, neither 17 beta-estradiol nor bFGF was capable of up-regulating Cyr61 mRNA in leiomyoma explants despite elevated levels of ER alpha mRNA, suggesting a possible defect in steroid and growth factor regulation.
|
11297607 |
2001 |
Uterine Fibroids
|
0.400 |
AlteredExpression
|
group |
BEFREE |
This is likely because the myometrial and leiomyoma cells begin to express the novel ER-beta upon culturing, and agonist-bound ER-beta is known to inhibit AP-1 activity.
|
11035987 |
2000 |
Uterine Fibroids
|
0.400 |
Biomarker
|
group |
BEFREE |
Eighty-percent of LM and 70% of the ULMS were estrogen receptor positive, whereas only one retroperitoneal tumor had focal weak positivity.
|
10574596 |
1999 |
Uterine Fibroids
|
0.400 |
Biomarker
|
group |
BEFREE |
The results presented here suggest that some exogenous ER ligands may mimic the effects of endogenous estrogens on uterine leiomyoma and may contribute to a complex hormonal milieu that impacts both normal and neoplastic myometrium.
|
10397250 |
1999 |
Uterine Fibroids
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Expression of exon 5 deleted estrogen receptor variant messenger RNA in human uterine myometrium and leiomyoma.
|
9780024 |
1998 |
Uterine Fibroids
|
0.400 |
AlteredExpression
|
group |
BEFREE |
To shed light on the molecular mechanisms involved in the pathogenesis of uterine leiomyomas, transcript levels of the immediate early genes c-fos, c-myc, and c-jun and of the estrogen receptor (ER) and progesterone receptor (PR) were determined in tissue samples of human myometrium and leiomyoma.
|
9253340 |
1997 |
Uterine Fibroids
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We propose that increased expression of progesterone receptor in leiomyoma is most likely a consequence of overexpression of functional ER that results in increased end-organ sensitivity to estradiol.
|
7775635 |
1995 |