Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
In the present study, we explored the effects of a grape seed extract (GSE) enriched in the flavan-3-ols procyanidin dimers on obesity-related cardiovascular and metabolic disorders; with a particular interest in the role/contribution of ERα.
|
29740325 |
2018 |
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Increased mTORC1 signaling in obesity ensures the strong activation of oncogenic signaling in E2Rα-positive breast cancer cells.
|
30620711 |
2019 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
It appears likely that ESR1 contributes to type 2 diabetes and CVD risk via pleiotropic effects, leading to insulin resistance, a poor lipid profile, and obesity.
|
17513703 |
2007 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Loss of ESR1 increases weight gain and obesity in female rats, while reducing the normal growth in males.
|
30974146 |
2019 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
N-terminal transactivation function, AF-1, of estrogen receptor alpha controls obesity through enhancement of energy expenditure.
|
30287090 |
2018 |
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that polymorphisms of the ESR1 gene do not contribute significantly to the genetic risk for obesity phenotypes in a population of young Caucasian adults.
|
28627236 |
2018 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Selective Activation of Estrogen Receptor α Activation Function-1 Is Sufficient to Prevent Obesity, Steatosis, and Insulin Resistance in Mouse.
|
28502695 |
2017 |
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Since obesity and osteoporosis present a high genetic predisposition and polymorphisms of IL-6, IL6R, LRP5, ESR1 and SP7 may influence the risk of both diseases, the aim of this study was to analyze the possible association of polymorphisms in these genes, as well as their haplotypes, with BMD variations in postmenopausal Mexican-Mestizo women with grade 2 or grade 3 obesity.
|
23891823 |
2013 |
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The rs2234693 C allele of ESR1 and its associated genotypes and haplotypes were inversely and consistently associated with obesity.
|
19375130 |
2009 |
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The aim of this retrospective study was to explore the possible correlation in the EC microenvironment between master regulators of complex phenomena such as steroid responsiveness through estrogen receptor alpha (ERα) and progesterone receptor (PR), epithelial-to-mesenchymal transition (supported by SLUG transcription factor), hypoxia (with hypoxia inducible factor-1 alpha, HIF-1α), and obesity that has been recognized as a EC risk factor.
|
31220580 |
2019 |
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The association between obesity and breast cancer risk and prognosis is well established in estrogen receptor (ER)-positive disease but less clear in HER2-positive disease.
|
28373182 |
2017 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The combination of overweight/obesity and elevated breast density in premenopausal women is associated with a higher risk of ER-negative compared with ER-positive cancer.
|
30944014 |
2019 |
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The data suggest a possibility that dietary <i>S</i>-equol could be an alternative to hormone replacement therapy for the prevention of hyperphagia and obesity with a lower risk of adverse effects induced by ER-α stimulation.
|
29097993 |
2017 |
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The insulin signaling network is influenced by obesity and may interact with the estrogen receptor α (ERα) signaling.
|
29234306 |
2017 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The role of progesterone receptor (PR) status on the association between obesity and prognosis of estrogen receptor positive (ER+) breast cancer (BC) remains poorly understood.
|
31403177 |
2020 |
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that adipocytes can modify breast cancer cell ER gene expression through hypoxia and also can promote EMT processes in breast cancer cells, supporting an important role of obesity in aggressive breast cancer development.
|
25823469 |
2015 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Thus, it is speculated that such ESR1 epigenetic changes may be influenced or shaped by obesity and reproductive history-related factors before and during breast carcinogenesis.
|
28708432 |
2017 |
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To determine whether oestrogen receptor (ER)alpha messenger RNA (mRNA) levels or single nucleotide polymorphisms (SNPs) are associated with obesity in Swedish women.
|
17224934 |
2007 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
To evaluate the relationship between obesity and the ratio of estrogen receptor subtypes (ERalpha/ERbeta) in adipose tissues in pre- and postmenopausal women, we measured the anthropometric indices of 31 premenopausal women and 12 postmenopausal women.
|
17509633 |
2007 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
To investigate the contribution of serum levels of testosterone (TS) and sex hormone binding globulin (SHBG) in association with body mass index (BMI) as a surrogate marker of obesity, to the predictive capability of tumor size (T), lymph node (N) and estrogen receptor (ER) status and proliferative activity (TLI).
|
29474646 |
2018 |
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Variants of estrogen receptor α (ERα) have been associated with obesity, dyslipidemia, diabetes and blood pressure.
|
24140101 |
2014 |
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
We assessed the associations between BMI and gene expression of both breast tumor and adjacent tissue in estrogen receptor-positive (ER+) and estrogen receptor-negative (ER-) diseases to help elucidate the mechanisms linking obesity with breast cancer biology in 519 post-menopausal women from the Nurses' Health Study (NHS) and NHSII.
|
30387004 |
2019 |
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We studied the significance of BsmI restriction enzyme polymorphism of the vitamin D receptor (VDR) gene and the XbaI and PvuII polymorphisms of the estrogen receptor (ER) gene in patients with type 2 diabetes (n=49), android type obesity with normal carbohydrate metabolism (n=29) and healthy controls (n=138).
|
11275948 |
2001 |