|
Disseminated Intravascular Coagulation
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Abbreviations: AML: acute myeloid leukemia; APL: acute promyelocytic leukemia; WBC: white blood cell; RBC: red blood cell; Hb: hemoglobin; PT: prothrombin time; TT: thrombin time; APTT: activated partial thromboplastin time; TP: total protein; ALB: albumin; AST: aspartate transaminase; ALT: alanine aminotransferase; LDH: lactate dehydrogenase; ATRA: all-trans retinoic acid; ICH: intracranial hemorrhage; DIC: disseminated intravascular coagulation.
|
30453810 |
2019 |
|
Disseminated Intravascular Coagulation
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The levels of PT and activated partial thromboplastin time were higher, and the fibrinogen level was lower in patients with overt DIC.
|
29065752 |
2019 |
|
Disseminated Intravascular Coagulation
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
This responded to standard advanced life support, but he had an unrecordably high international normalised ratio (INR), activated partial thromboplastin time and unrecordably low fibrinogen, consistent with a complete venom-induced consumption coagulopathy.
|
30885617 |
2019 |
|
Disseminated Intravascular Coagulation
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this study, we aim to investigate the effects of TM alfa on platelet aggregation using lipopolysaccharide (LPS)-induced and tissue factor (TF)-induced DIC rat models.
|
31096113 |
2019 |
|
Disseminated Intravascular Coagulation
|
0.600 |
Biomarker
|
disease |
BEFREE |
Infection of Mϕs stimulates the production of proinflammatory and immunomodulatory cytokines and chemokines, leading to the production of a cytokine storm, while simultaneously increasing tissue factor production and thus facilitating disseminated intravascular coagulation.
|
30095866 |
2018 |
|
Disseminated Intravascular Coagulation
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In sepsis, inducible TF expression on monocytes leads to disseminated intravascular coagulation.
|
29437578 |
2018 |
|
Disseminated Intravascular Coagulation
|
0.600 |
Biomarker
|
disease |
BEFREE |
Procoagulant phosphatidylserine (PS)- and tissue factor (TF)-exposing extracellular vesicles (EVs) might play an important role in AF embolism-induced DIC.
|
28236427 |
2017 |
|
Disseminated Intravascular Coagulation
|
0.600 |
Biomarker
|
disease |
BEFREE |
In sepsis, binding of factor VII (FVII:C) and activated factor VII (FVIIa) with tissue factor is the key step of coagulation resulting in disseminated intravascular coagulation (DIC).
|
28492702 |
2017 |
|
Disseminated Intravascular Coagulation
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
From medical records, we collected information about the following coagulation and fibrinolytic factors at hospital admission: platelet count; prothrombin time; activated partial thromboplastin time; plasma levels of fibrinogen, D-dimer, fibrin/fibrinogen degradation products (FDP), and antithrombin; and calculated DIC score.
|
27940211 |
2017 |
|
Disseminated Intravascular Coagulation
|
0.600 |
Biomarker
|
disease |
BEFREE |
Initial laboratory testing showed thrombocytopenia, further testing showed deranged prothrombin time, partial thromboplastin time, decreased fibrinogen, and elevated D-dimer, suggesting disseminated intravascular coagulation.
|
22713531 |
2015 |
|
Disseminated Intravascular Coagulation
|
0.600 |
Biomarker
|
disease |
BEFREE |
Tissue factor is the major protease that drives the pathology of DIC.
|
26410136 |
2015 |
|
Disseminated Intravascular Coagulation
|
0.600 |
Biomarker
|
disease |
BEFREE |
Delayed bleeding is often ascribed to consumptive coagulopathy initiated by exposed brain tissue factor.
|
25673638 |
2015 |
|
Disseminated Intravascular Coagulation
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Liver xenografts induce rapid and profound thrombocytopenia resulting in recipient death within days due to bleeding; ex-vivo data suggest that liver endothelial cells and hepatocytes are responsible for platelet consumption by a coagulation-independent process.It has been proposed that expression of recipient tissue factor on platelets and monocytes is an important trigger of consumptive coagulopathy.
|
21415824 |
2011 |
|
Disseminated Intravascular Coagulation
|
0.600 |
Biomarker
|
disease |
CTD_human |
Activation of platelets to express TF was associated with the initiation of CC, whereas TF expression on PBMCs was concomitant with the onset of CC, often in the relative absence of features of acute humoral xenograft rejection.
|
20642682 |
2010 |
|
Disseminated Intravascular Coagulation
|
0.600 |
Biomarker
|
disease |
BEFREE |
The shedding of TF-containing membrane particles is believed to influence the ability of tumors to expand and metastasize, and these microparticles may also be harmful in the onset of disseminated intravascular coagulation in specific cancers.
|
19794520 |
2009 |
|
Disseminated Intravascular Coagulation
|
0.600 |
Biomarker
|
disease |
BEFREE |
Tissue factor (TF) plays a central role during disseminated intravascular coagulation (DIC) in sepsis.
|
16634740 |
2006 |
|
Disseminated Intravascular Coagulation
|
0.600 |
Biomarker
|
disease |
BEFREE |
Tissue factor (TF), the main initiator of blood coagulation, contributes to the manifestation of disseminated intravascular coagulation following septic shock in meningococcal infection.
|
16411400 |
2005 |
|
Disseminated Intravascular Coagulation
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Although TF mRNA levels in leukocytes were higher in patients with DVT than in healthy volunteers, they were lower in patients with DVT than in those with solid cancer and those with disseminated intravascular coagulation (DIC).
|
16038715 |
2005 |
|
Disseminated Intravascular Coagulation
|
0.600 |
Biomarker
|
disease |
BEFREE |
Pathogenetic pathways that play a role in the development of DIC include tissue factor-dependent activation of coagulation, defective physiological anticoagulant pathways (such as the antithrombin system and the protein C system), and impaired fibrinolysis, caused by elevated levels of plasminogen activator inhibitor type 1.
|
15992667 |
2005 |
|
Disseminated Intravascular Coagulation
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
TF mRNA levels in leukocytes and plasma levels of TF antigen did not correlate in normal subjects and all patients, but they tended to be correlated in patients with AML, infections or overt-DIC.
|
15213854 |
2004 |
|
Disseminated Intravascular Coagulation
|
0.600 |
Biomarker
|
disease |
BEFREE |
However, the emerging role of TF in the pathogenesis of diseases such as sepsis, atherosclerosis, certain cancers and diseases characterized by pathological fibrin deposition such as disseminated intravascular coagulation and thrombosis, has directed attention to the development of novel inhibitors of tissue factor for use as antithrombotic drugs.
|
15389118 |
2004 |
|
Disseminated Intravascular Coagulation
|
0.600 |
Biomarker
|
disease |
BEFREE |
Group 1 and 2 animals developed features of disseminated intravascular coagulation (DIC), with reductions of fibrinogen and platelets and increases of prothrombin time, partial thromboplastin time, and fibrin split products.Graft survival was for 6-13 days.
|
11740383 |
2001 |
|
Disseminated Intravascular Coagulation
|
0.600 |
Biomarker
|
disease |
BEFREE |
Because the binding of a fVII immunoconjugate to TF might cause disseminated intravascular coagulation, the active site of fVII was mutated to inhibit coagulation without affecting the affinity for TF.
|
10393965 |
1999 |
|
Disseminated Intravascular Coagulation
|
0.600 |
Biomarker
|
disease |
RGD |
These results indicate that imbalance between TF and TFPI, overexpression of TF, and underexpression of TFPI in the lung may contribute to thrombus formation in this LPS-induced DIC model.
|
9426395 |
1997 |
|
Disseminated Intravascular Coagulation
|
0.600 |
Biomarker
|
disease |
CTD_human |
We therefore further compared the antithrombotic (Benefit: dose required for 50% inhibition of fibrinogen decrease: ED50) and hemorrhagic (Risk: minimum dose required for significant prolongation of bleeding time) effects of MR-33 and LMW-heparin in the thromboplastin-induced DIC model.
|
9134660 |
1997 |