Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
FcGR genetic polymorphisms and the response to adalimumab in patients with rheumatoid arthritis.
|
25823785 |
2015 |
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
No relation was found between the FCGR2A polymorphism and susceptibility to RA in Europeans or Asians.
|
18843786 |
2008 |
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Although no relationship was found between the FCGR3B polymorphism and RA susceptibility, FCGR2A and FCGR3A polymorphisms were found to be associated with RA in Europeans, but not in Asians.
|
26314337 |
2015 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
LHGDN |
Immune complexes from rheumatoid arthritis synovial fluid induce FcgammaRIIa dependent and rheumatoid factor correlated production of tumour necrosis factor-alpha by peripheral blood mononuclear cells.
|
16569263 |
2006 |
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Plasma levels of the soluble form of the FcγRIIa receptor vary with receptor polymorphisms and are elevated in rheumatoid arthritis.
|
31378115 |
2020 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
FcγRIIa-131H allele may have a protective role in autoantibody production and might be a biomarker for predicting good response to TNFi in Chinese RA patients.
|
28112584 |
2017 |
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci.
|
24532676 |
2015 |
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Analyzing the subset of anti-CCP positive RA patients (78%), we also found a significant association between FCGR2A and the response to infliximab (P=0.035).
|
25848939 |
2015 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
CTD_human |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
|
20453842 |
2010 |
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our data indicate that FCGR2A polymorphism may influence the response to TNF-α blockers (namely etanercept) in PsA in a direction opposite to that previously found in patients with rheumatoid arthritis.
|
22467926 |
2012 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
More detailed analysis of intimal lining layer macrophages revealed a strong co-expression of the IL-10 polarization markers CD163 and cluster of differentiation 32 (CD32) but not any of the other markers in both SpA and RA.
|
22494514 |
2012 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
A trans-ethnic genetic study of rheumatoid arthritis identified FCGR2A as a candidate common risk factor in Japanese and European populations.
|
21607711 |
2012 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
The CD32a immunoglobulin G (IgG) receptor (Fcγ receptor IIa) is a potential therapeutic target for diseases in which IgG immune complexes (ICs) mediate inflammation, such as heparin-induced thrombocytopenia, rheumatoid arthritis, and systemic lupus erythematosus.
|
26396093 |
2015 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our results reveal that FCGR2A, FCGR2B and FCGR3B were not associated with RA.
|
16356189 |
2006 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
In total, 25 single nucleotide polymorphisms were found to be associated with anti-TNF treatment response in RA (19 from genome-wide association studies and 6 from the meta-analyses), and these map to genes involved in T cell function, NFκB and TNF signalling pathways (including CTCN5, TEC, PTPRC, FCGR2A, NFKBIB, FCGR2A, IRAK3).
|
28607508 |
2017 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Association of FCGR2A with the response to infliximab treatment of patients with rheumatoid arthritis.
|
24667440 |
2014 |
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies in rheumatoid arthritis (RA) have failed to examine the FCGR gene cluster because of the confounding effects of segmental duplication.
|
19700393 |
2010 |
Rheumatoid Arthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Compared with the control group, i-RA and a-RA patients exhibited: (1) increased neutrophil ROS production and membrane expression of FcγRIIa/CD32, FcγRIIIb/CD16, and CR1/CD35, indicating neutrophil activation; and (2) increased serum chemotactic activity and decreased activity of the alternative complement pathway, indicating systemic complement system activation.
|
29464314 |
2018 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Significantly higher mean frequencies of cells presenting CD11b and CD32 from whole blood were observed in patients with AOSD than in patients with RA or HC.
|
28106835 |
2017 |
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
FCGR polymorphisms in the treatment of rheumatoid arthritis with Fc-containing TNF inhibitors.
|
25823782 |
2015 |
Rheumatoid Arthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The combination of the FcgammaRIIIA-176F allele with a lack of CD32 expression in NK cells appeared to be characteristic of RA subjects with aggressive disease.
|
15334114 |
2004 |
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The PTPRC rs10919563 A allele shows a poor response to anti-TNF therapy, and the FCGR2A HH + HR genotype shows a poor response to adalimumab for RA.
|
27074847 |
2016 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
The relationship between functional single nucleotide polymorphisms (SNP) of the FCGR2A and FCGR3A genes and the response to anti-tumour necrosis factor (TNF)alpha therapy (infliximab) in patients with rheumatoid arthritis (RA) was assessed.
|
18930989 |
2009 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
LHGDN |
Immunoglobulin G fc-receptor (FcgammaR) IIA, IIIA, and IIIB polymorphisms related to disease severity in rheumatoid arthritis.
|
12064825 |
2002 |