Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
FC gamma RIIa polymorphism in patients with rheumatoid arthritis.
|
12508778 |
2003 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Isolated FcgR genes do not play a major independent role in susceptibility to RA.
|
12734884 |
2003 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
After testing an independent cohort of 2,009 cases of ulcerative colitis and 1,580 controls, we identified 13 loci that were significantly associated with ulcerative colitis (P < 5 x 10(-8)), including the immunoglobulin receptor gene FCGR2A, 5p15, 2p16 and ORMDL3 (orosomucoid1-like 3).
|
20228799 |
2010 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
|
28067908 |
2017 |
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
CTD_human |
A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.
|
19915573 |
2009 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis demonstrates that the FCGR2A rs1801274 G-allele confers susceptibility to KD and UC.
|
27270653 |
2016 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The FcgR2a*519G functional variant was associated with IBD and reduced susceptibility to UC and to CD in Caucasians.
|
20848524 |
2010 |
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our results suggest that organizing handling of immune complex by FCGR3A, FCGR3B, and FCGR2A may play a crucial role in the pathogenesis of UC.
|
23917248 |
2013 |
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
In recent years, there has been renewed interest in the role of IgG in intestinal immunity, driven in part by a genetic association of an affinity-lowering variant of an IgG receptor, FcγRIIA, with protection from ulcerative colitis (UC), a subclass of inflammatory bowel disease (IBD).
|
31480888 |
2019 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that FCGR2A, JAK2 or HNF4A variants play a role in the pathogenesis of ulcerative colitis in Koreans.
|
21831733 |
2011 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
|
21297633 |
2011 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our suggestive finding that the association between dietary heme iron intake and risk of UC may be modified by a coding variant in FcγRIIA gene warrants additional investigation.
|
28604414 |
2017 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The TC haplotype constructed by the major allele of FCGR2A (rs1801274 and rs511278) was more prevalent in UC patients compared with controls (65.2% vs. 60.2%, p = 0.017).
|
30260678 |
2018 |
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Specifically, a variant of the activating receptor, FcγRIIA, with low affinity for IgG, confers protection against the development of ulcerative colitis, a subset of IBD, leading to a re-evaluation of the role of IgG and FcγRs in gastrointestinal tract immunity, an organ system traditionally associated with IgA.
|
31031776 |
2019 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.
|
19915573 |
2009 |
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
CTD_human |
After testing an independent cohort of 2,009 cases of ulcerative colitis and 1,580 controls, we identified 13 loci that were significantly associated with ulcerative colitis (P < 5 x 10(-8)), including the immunoglobulin receptor gene FCGR2A, 5p15, 2p16 and ORMDL3 (orosomucoid1-like 3).
|
20228799 |
2010 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.
|
19915573 |
2009 |
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Genome-wide association studies in ulcerative colitis point to a role for FcγRIIA, a receptor for IgG.Castro-Dopico et al.
|
30995495 |
2019 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants of rs6671847 at FCGR2A and rs17085007 at 13q12 conferred a risk of relapse in patients with UC.
|
25787843 |
2015 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We confirmed the associations of 10 known UC risk loci in Koreans: rs76418789 in IL23R (combined P = 1.25 × 10), rs4728142 in IRF5 (combined P = 3.17 × 10), rs1830610 near JAK2 (combined P = 2.28 × 10), rs1555791 near TNFRSF14 (combined P = 1.62 × 10), rs880790 between IL10-IL19 (combined P = 3.73 × 10), rs10185424 between IL1R2-IL1R1 (combined P = 1.54 × 10), rs6478108 in TNFSF15 (combined P = 9.28 × 10), rs861857 between UBE2L3-YDJC (combined P = 3.05 × 10), rs1801274 in FCGR2A (discovery P = 1.54 × 10), and rs17085007 between GPR12-USP12 (discovery P = 3.64 × 10).
|
26398853 |
2016 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
|
21297633 |
2011 |
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies (GWASs) in UC implicate a FCGR2A variant that alters the binding affinity of the antibody receptor it encodes, FcγRIIA, for immunoglobulin G (IgG).
|
30876876 |
2019 |
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Further, we confirmed the genetic association between lupus and 5 additional lupus susceptibility loci (ITGAM, MSH5, CFB, STAT4, and FCGR2A; P = 7.5 × 10⁻¹¹, P = 5.2 × 10⁻⁸, P = 8.7 × 10⁻⁷ , P = 0.0058, and P = 0.0070, respectively), and provided evidence, for the first time, of genome-wide significance for the association between lupus in African American patients and ITGAM and MSH5 (HLA region).
|
21792837 |
2011 |
Lupus Erythematosus, Systemic
|
0.500 |
Biomarker
|
disease |
BEFREE |
The FCGR2B haplotype has no linkage disequilibrium with previously identified FCGR2A and FCGR3A polymorphisms, and after adjustment for FCGR2A and FCGR3A, FCGR2B showed a persistent association with SLE (odds ratio = 1.72; p = 0.0083).
|
15153543 |
2004 |