|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Plasma levels of the soluble form of the FcγRIIa receptor vary with receptor polymorphisms and are elevated in rheumatoid arthritis.
|
31378115 |
2020 |
|
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
In recent years, there has been renewed interest in the role of IgG in intestinal immunity, driven in part by a genetic association of an affinity-lowering variant of an IgG receptor, FcγRIIA, with protection from ulcerative colitis (UC), a subclass of inflammatory bowel disease (IBD).
|
31480888 |
2019 |
|
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Specifically, a variant of the activating receptor, FcγRIIA, with low affinity for IgG, confers protection against the development of ulcerative colitis, a subset of IBD, leading to a re-evaluation of the role of IgG and FcγRs in gastrointestinal tract immunity, an organ system traditionally associated with IgA.
|
31031776 |
2019 |
|
Ulcerative Colitis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Genome-wide association studies in ulcerative colitis point to a role for FcγRIIA, a receptor for IgG.Castro-Dopico et al.
|
30995495 |
2019 |
|
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies (GWASs) in UC implicate a FCGR2A variant that alters the binding affinity of the antibody receptor it encodes, FcγRIIA, for immunoglobulin G (IgG).
|
30876876 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Variations of the 5, 10- methylenetetrahydrofolate reductase (MTHFR) gene -the main genetic determinant of hyperhomocystenemia in humans-as well the interferon regulatory factor-8 (IRF8), FcγRIIA and BAFF genes have been all linked to subclinical atherosclerosis in SLE.
|
31444033 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
FcγRIIA represents a link that connects platelet activity, vascular health and CVD in SLE.
|
30638300 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.500 |
Biomarker
|
disease |
BEFREE |
These data indicate the SLE-derived ICs activate neutrophils to release ROS and chemokines in an FcγRIIA-dependent and TLR7- and TLR9-independent manner that likely contributes to local tissue inflammation and damage.
|
30610165 |
2019 |
|
Mucocutaneous Lymph Node Syndrome
|
0.500 |
Biomarker
|
disease |
BEFREE |
HTA analysis revealed higher mRNA levels of FCAR, FCGR1C, and FCGR2A in KD patients.
|
31816620 |
2019 |
|
Mucocutaneous Lymph Node Syndrome
|
0.500 |
Biomarker
|
disease |
BEFREE |
Extensive Ethnic Variation and Linkage Disequilibrium at the <i>FCGR2/3</i> Locus: Different Genetic Associations Revealed in Kawasaki Disease.
|
30949161 |
2019 |
|
Rheumatoid Arthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Compared with the control group, i-RA and a-RA patients exhibited: (1) increased neutrophil ROS production and membrane expression of FcγRIIa/CD32, FcγRIIIb/CD16, and CR1/CD35, indicating neutrophil activation; and (2) increased serum chemotactic activity and decreased activity of the alternative complement pathway, indicating systemic complement system activation.
|
29464314 |
2018 |
|
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The TC haplotype constructed by the major allele of FCGR2A (rs1801274 and rs511278) was more prevalent in UC patients compared with controls (65.2% vs. 60.2%, p = 0.017).
|
30260678 |
2018 |
|
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
FcγRIIa-131H allele may have a protective role in autoantibody production and might be a biomarker for predicting good response to TNFi in Chinese RA patients.
|
28112584 |
2017 |
|
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
In total, 25 single nucleotide polymorphisms were found to be associated with anti-TNF treatment response in RA (19 from genome-wide association studies and 6 from the meta-analyses), and these map to genes involved in T cell function, NFκB and TNF signalling pathways (including CTCN5, TEC, PTPRC, FCGR2A, NFKBIB, FCGR2A, IRAK3).
|
28607508 |
2017 |
|
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Significantly higher mean frequencies of cells presenting CD11b and CD32 from whole blood were observed in patients with AOSD than in patients with RA or HC.
|
28106835 |
2017 |
|
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
|
28067908 |
2017 |
|
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our suggestive finding that the association between dietary heme iron intake and risk of UC may be modified by a coding variant in FcγRIIA gene warrants additional investigation.
|
28604414 |
2017 |
|
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Transancestral mapping and genetic load in systemic lupus erythematosus.
|
28714469 |
2017 |
|
Mucocutaneous Lymph Node Syndrome
|
0.500 |
PosttranslationalModification
|
disease |
BEFREE |
The activating FcγRIIA and inhibitory FcγRIIB methylation levels of seven patients with KD and four control subjects were examined using HumanMethylation27 BeadChip.
|
27893416 |
2017 |
|
Mucocutaneous Lymph Node Syndrome
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Male-specific association of the FCGR2A His167Arg polymorphism with Kawasaki disease.
|
28886140 |
2017 |
|
Mucocutaneous Lymph Node Syndrome
|
0.500 |
Biomarker
|
disease |
BEFREE |
Overall, the gender differences associated with FCGR2A in KD provide a new insight into KD susceptibility.
|
28886140 |
2017 |
|
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The PTPRC rs10919563 A allele shows a poor response to anti-TNF therapy, and the FCGR2A HH + HR genotype shows a poor response to adalimumab for RA.
|
27074847 |
2016 |
|
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis demonstrates that the FCGR2A rs1801274 G-allele confers susceptibility to KD and UC.
|
27270653 |
2016 |
|
Ulcerative Colitis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We confirmed the associations of 10 known UC risk loci in Koreans: rs76418789 in IL23R (combined P = 1.25 × 10), rs4728142 in IRF5 (combined P = 3.17 × 10), rs1830610 near JAK2 (combined P = 2.28 × 10), rs1555791 near TNFRSF14 (combined P = 1.62 × 10), rs880790 between IL10-IL19 (combined P = 3.73 × 10), rs10185424 between IL1R2-IL1R1 (combined P = 1.54 × 10), rs6478108 in TNFSF15 (combined P = 9.28 × 10), rs861857 between UBE2L3-YDJC (combined P = 3.05 × 10), rs1801274 in FCGR2A (discovery P = 1.54 × 10), and rs17085007 between GPR12-USP12 (discovery P = 3.64 × 10).
|
26398853 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Comprehensive Assessment of the Association between FCGRs polymorphisms and the risk of systemic lupus erythematosus: Evidence from a Meta-Analysis.
|
27538381 |
2016 |