FCGR2A, Fc fragment of IgG receptor IIa, 2212

N. diseases: 227; N. variants: 13
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0349506
Disease: Photosensitivity of skin
Photosensitivity of skin 		0.100 Biomarker phenotype HPO
CUI: C0694550
Disease: Recurrent pneumonia
Recurrent pneumonia 		0.100 Biomarker disease HPO
CUI: C0746102
Disease: Chronic lung disease
Chronic lung disease 		0.100 Biomarker disease HPO
CUI: C1856646
Disease: Elevated sweat chloride
Elevated sweat chloride 		0.100 Biomarker phenotype HPO
CUI: C2169795
Disease: Recurrent bronchopulmonary infections
Recurrent bronchopulmonary infections 		0.100 Biomarker phenotype HPO
CUI: C2939175
Disease: Meconium ileus
Meconium ileus 		0.100 Biomarker disease HPO
CUI: C4019436
Disease: Antiphospholipid antibody positivity
Antiphospholipid antibody positivity 		0.100 Biomarker phenotype HPO
CUI: C0024299
Disease: Lymphoma
Lymphoma 		0.020 Biomarker group BEFREE Neoplastic follicles in the remaining nine cases, which showed the features of MALT lymphoma, were of a different phenotype (Ig light-chain restriction, CD10- KB61(CDw32)+), and these lymphomas showed Jh but not bcl-2 gene rearrangement. 1951841 1991
CUI: C0043020
Disease: Wallerian Degeneration
Wallerian Degeneration 		0.200 Biomarker phenotype RGD Expression of genes encoding receptors for IgG (FcRIII) and for C3b/C4b (Crry) in rat sciatic nerve during development and Wallerian degeneration. 1533683 1992
CUI: C0023418
Disease: leukemia
leukemia 		0.010 Biomarker disease BEFREE Leukemia cell survival also could be enhanced by exogenous IFN-gamma or anti-CD40 presented on Fc gamma RII (CDw32)-expressing L cells, but not by exogenous IL-4, IL-6, or monomeric human IgG. 7505024 1993
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.010 Biomarker disease BEFREE Leukemia cell survival also could be enhanced by exogenous IFN-gamma or anti-CD40 presented on Fc gamma RII (CDw32)-expressing L cells, but not by exogenous IL-4, IL-6, or monomeric human IgG. 7505024 1993
CUI: C0035243
Disease: Respiratory Tract Infections
Respiratory Tract Infections 		0.010 Biomarker group BEFREE Fc gamma receptor IIa (CD32) heterogeneity in patients with recurrent bacterial respiratory tract infections. 7930727 1994
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.500 GeneticVariation disease BEFREE Skewed distribution of IgG Fc receptor IIa (CD32) polymorphism is associated with renal disease in systemic lupus erythematosus patients. 8849356 1995
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases 		0.010 GeneticVariation group BEFREE Skewed distribution of IgG Fc receptor IIa (CD32) polymorphism is associated with renal disease in systemic lupus erythematosus patients. 8849356 1995
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.500 GeneticVariation disease BEFREE Recent studies in human systemic lupus erythematosus have found an association with a particular FCGR2A allele. 8994865 1996
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis 		0.050 Biomarker disease BEFREE Therefore, since immune complex clearance is essential in SLE, we hypothesized that Fc gamma RIIA genes are important disease susceptibility factors for SLE, particularly lupus nephritis. 8636449 1996
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell 		0.010 GeneticVariation disease BEFREE The His(H)-Arg(R) polymorphism at amino acid 131 of the Fc gamma RIIA receptor alters binding affinity for human IgG2 and influences infection with encapsulated organisms in children without sickle cell disease. 8648541 1996
CUI: C0024305
Disease: Lymphoma, Non-Hodgkin
Lymphoma, Non-Hodgkin 		0.040 Biomarker disease BEFREE Coculture with CD40L L cells, but not with CDw32 L cells, inhibited (38% to 100%) the activation of caspase 3 induced by 0.1 to 0.5 microgram/mL of DOX in all five NHL cell lines, but in only two cell lines at 1 microgram/mL. 9787177 1998
CUI: C0025303
Disease: Meningococcal Infections
Meningococcal Infections 		0.020 GeneticVariation group BEFREE Association of human Fc gamma RIIa (CD32) polymorphism with susceptibility to and severity of meningococcal disease. 9798027 1998
CUI: C0025303
Disease: Meningococcal Infections
Meningococcal Infections 		0.020 GeneticVariation group BEFREE Meningococcal disease and polymorphism of FcgammaRIIa (CD32) in late complement component-deficient individuals. 9472667 1998
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.010 Biomarker disease BEFREE GPRE increased the fraction of blasts expressing CD11b and CD32 in AML-M2 and -M5. 9669838 1998
CUI: C0151436
Disease: Vasculitis, Leukocytoclastic, Cutaneous
Vasculitis, Leukocytoclastic, Cutaneous 		0.010 Biomarker disease BEFREE CD32/immunoglobulin G subtypes/leukocytoclastic vasculitis/microvessels. 10417619 1999
CUI: C2973529
Disease: Leukocytoclastic vasculitis
Leukocytoclastic vasculitis 		0.010 Biomarker disease BEFREE CD32/immunoglobulin G subtypes/leukocytoclastic vasculitis/microvessels. 10417619 1999
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.500 Biomarker disease BEFREE To determine whether 7 candidate genes, including tumor necrosis factor receptor II, bcl-2, CTLA-4, interleukin-10 (IL-10), CD19, Fcy receptor type IIA (CD32), and IL-1 receptor antagonist, may contribute to susceptibility to systemic lupus erythematosus (SLE) in the Italian population. 10643707 2000
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.040 AlteredExpression group BEFREE Exposure of U-87MG cells to GH-RH antagonists in vitro also resulted in a time-dependent increase in the mRNA levels of IGFR-II or a decrease in the mRNA levels of IGFR-I. mRNA for GH-RH was detected in U-87MG cells and xenografts implying that GH-RH may play a role in the pathogenesis of this tumor. 10935510 2000