|
Myocardial Infarction
|
0.390 |
Biomarker
|
disease |
CTD_human |
[Association of a polymorphic marker Trp719Arg of KIF6 gene with effects of atorvastatin and simvastatin in patients with early ischemic heart disease].
|
21943003 |
2011 |
|
Myocardial Infarction
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
With regard to the primary CHD endpoint on trial (fatal or non-fatal myocardial infarction or stroke), we observed a significant relationship for KIF6 719Arg homozygotes (p=0.03, hazards ratio 0.47, 12.8% of the population) in women on pravastatin only, and for TAS2R50 for the AA genotype (p=0.03, hazards ratio 1.76, 8.9% of the population), also only in women on pravastatin.
|
22192511 |
2012 |
|
Myocardial Infarction
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Confirming and extending previous reports, carriers of the 719Arg allele of KIF6 have 34% higher risk of myocardial infarction and 24% higher risk of CHD compared with noncarriers among 25,283 women from the WHS.
|
18222354 |
2008 |
|
Myocardial Infarction
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
In summary, carriers of the KIF6 719Arg allele were not at increased risk of CAD/non-fatal MI in a case-control study of Indians (Indo-Europeans) living in Western India.
|
21810021 |
2011 |
|
Myocardial Infarction
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
A KIF6 variant in man has been reported to be associated with adverse cardiovascular outcomes after myocardial infarction.
|
23355886 |
2013 |
|
Myocardial Infarction
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
We found that carriers of the KIF6 719Arg allele were not at increased risk of non-fatal MI in a case-control study of Costa Ricans living in the Central Valley of Costa Rica.
|
20927332 |
2010 |
|
Myocardial Infarction
|
0.390 |
GeneticVariation
|
disease |
LHGDN |
Confirming and extending previous reports, carriers of the 719Arg allele of KIF6 have 34% higher risk of myocardial infarction and 24% higher risk of CHD compared with noncarriers among 25,283 women from the WHS.
|
18222354 |
2008 |
|
Myocardial Infarction
|
0.390 |
Biomarker
|
disease |
BEFREE |
The effect of kinesin family member 6 (KIF6) on statin therapy was also examined among patients who had a history of one or two heart attacks.
|
26443250 |
2015 |
|
Myocardial Infarction
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Our findings indicate that the Trp719Arg polymorphism of the KIF6 gene is an important risk factor for developing MI and that allele 719Arg may have a protective association to present CHD in all populations.
|
28096762 |
2015 |
|
Myocardial Infarction
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Of the 170 SNPs in the KIF6 region investigated in the Cholesterol and Recurrent Events trial (CARE), 28 were associated with differential event reduction from statin therapy (P (interaction) < 01 in Caucasians, adjusted for age and sex) and were further investigated in the Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction 22 (PROVE IT-TIMI22) and West of Scotland Coronary Prevention Study (WOSCOPS).
|
20886236 |
2011 |
|
Myocardial Infarction
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
The contribution of a 9p21.3 variant, a KIF6 variant, and C-reactive protein to predicting risk of myocardial infarction in a prospective study.
|
21406102 |
2011 |
|
Malignant neoplasm of breast
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Association of the 719Arg variant of KIF6 with both increased risk of coronary events and with greater response to statin therapy.
|
18510970 |
2008 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Meta-analyses of KIF6 Trp719Arg in coronary heart disease and statin therapeutic effect.
|
23236363 |
2012 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Impact of KIF6 Polymorphism rs20455 on Coronary Heart Disease Risk and Effectiveness of Statin Therapy in 100 Patients from Southern Iran.
|
26443250 |
2015 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Confirming and extending previous reports, carriers of the 719Arg allele of KIF6 have 34% higher risk of myocardial infarction and 24% higher risk of CHD compared with noncarriers among 25,283 women from the WHS.
|
18222354 |
2008 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Investigation of KIF6 Trp719Arg in a case-control study of coronary artery disease in Western Indians.
|
21810021 |
2011 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Evidence from multiple large prospective studies suggests that a common polymorphism that encodes an arginine (Arg)-to-tryptophan substitution at position 719 in the KIF6 gene is associated with coronary heart disease (CHD) and reduction in coronary events from statin therapy.
|
20854963 |
2010 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A variant of KIF6 (719Arg) has also been reported to be associated with increased risk of CHD in large prospective studies, but not in case-control studies.
|
21406102 |
2011 |
|
Coronary heart disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Functional studies of these variants may help to understand the role of KIF6 in the pathogenesis of CHD and differential response to statin therapy.
|
20886236 |
2011 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Whereas six prospective studies have shown that carriers of the KIF6 Trp719Arg risk allele have 20% to 50% greater CHD risk than non-carriers, several cross-sectional case-control studies failed to show that carrier status is related to CHD.
|
21435211 |
2011 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data indicate that the assessment of KIF6 rs20455 and TAS2R50 rs1376251 genotypes are not useful for predicting statin induced cardiovascular risk reduction in men, but do predict CHD risk reduction in women in this elderly population.
|
22192511 |
2012 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Novel KIF6 polymorphism increases susceptibility to type 2 diabetes mellitus and coronary heart disease in Han Chinese men.
|
25629058 |
2014 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There are no significant association found between KIF6 rs20455 polymorphism and CHD risk (Homozygote model: OR = 1.007, 95% CI =0.952-1.066, P = 0.801; Heterozygote model: OR = 1.009, 95% CI = 0.968-1.052, P = 0.636; Dominant model: OR = 1.007, 95% CI = 0.966-1.048, P = 0.753; Recessive model: OR = 0.989, 95% CI = 0.943-1.037, P = 0.655; Allele comparison model: OR = 1.00, 95% CI = 0.971-1.030, P = 0.988).
|
29304815 |
2018 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Studies and abstracts investigating the relationship between the Trp719Arg polymorphism of KIF6 and subsequent risk for development of CHD were reviewed.
|
28096762 |
2015 |