|
Malignant neoplasm of breast
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Arteriosclerosis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We considered five variants that were associated with coronary heart disease in two studies and confirmed in the Atherosclerosis Risk in Communities study: rs20455 (KIF6), rs3900940 (MYH15), rs7439293 (PALLD), rs2298566 (SNX19), and rs1010 (VAMP8).
|
18073581 |
2007 |
|
Atherosclerosis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We considered five variants that were associated with coronary heart disease in two studies and confirmed in the Atherosclerosis Risk in Communities study: rs20455 (KIF6), rs3900940 (MYH15), rs7439293 (PALLD), rs2298566 (SNX19), and rs1010 (VAMP8).
|
18073581 |
2007 |
|
Myocardial Infarction
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Confirming and extending previous reports, carriers of the 719Arg allele of KIF6 have 34% higher risk of myocardial infarction and 24% higher risk of CHD compared with noncarriers among 25,283 women from the WHS.
|
18222354 |
2008 |
|
Myocardial Infarction
|
0.390 |
GeneticVariation
|
disease |
LHGDN |
Confirming and extending previous reports, carriers of the 719Arg allele of KIF6 have 34% higher risk of myocardial infarction and 24% higher risk of CHD compared with noncarriers among 25,283 women from the WHS.
|
18222354 |
2008 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Association of the 719Arg variant of KIF6 with both increased risk of coronary events and with greater response to statin therapy.
|
18510970 |
2008 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Confirming and extending previous reports, carriers of the 719Arg allele of KIF6 have 34% higher risk of myocardial infarction and 24% higher risk of CHD compared with noncarriers among 25,283 women from the WHS.
|
18222354 |
2008 |
|
Coronary Artery Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health Study.
|
18222354 |
2008 |
|
Coronary Arteriosclerosis
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health Study.
|
18222354 |
2008 |
|
Cardiovascular Diseases
|
0.050 |
GeneticVariation
|
group |
BEFREE |
The 4 of these 8 SNPs that had the strongest evidence for association with cardiovascular disease before testing in CHS (association in 3 antecedent studies) were in KIF6 (CHS HR=1.29; 90%CI 1.1 to 1.52), VAMP8 (HR=1.2; 90%CI 1.02 to 1.41), TAS2R50 (HR=1.13; 90%CI 1 to 1.27), and LPA (HR=1.62; 90%CI 1.09 to 2.42).
|
17975119 |
2008 |
|
Arteriosclerosis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The 719Arg allele of KIF6 (rs20455) has been reported to be associated with increased risk of CHD in a large population-based prospective study, ARIC (Atherosclerosis Risk in Communities), and in the placebo arms of 2 statin trials, CARE (Cholesterol and Recurrent Events) and WOSCOPS (West of Scotland Coronary Prevention Study).
|
18222354 |
2008 |
|
Atherosclerosis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The 719Arg allele of KIF6 (rs20455) has been reported to be associated with increased risk of CHD in a large population-based prospective study, ARIC (Atherosclerosis Risk in Communities), and in the placebo arms of 2 statin trials, CARE (Cholesterol and Recurrent Events) and WOSCOPS (West of Scotland Coronary Prevention Study).
|
18222354 |
2008 |
|
Acute Coronary Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: results from the PROVE IT-TIMI 22 study.
|
18222355 |
2008 |
|
Cerebrovascular accident
|
0.020 |
GeneticVariation
|
group |
BEFREE |
The odds ratios for noncardioembolic stroke were 1.31 (90% CI 1.07-1.60) for rs3900940 in MYH15, 1.24 (90% CI 1.01-1.5) for rs20455 in KIF6, 1.21 (90% CI 0.99-1.49) for rs1010 in VAMP8, and 1.20 (90% CI 0.95-1.50) for rs10757274 on chromosome 9p21.
|
19752551 |
2009 |
|
Myocardial Infarction
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
We found that carriers of the KIF6 719Arg allele were not at increased risk of non-fatal MI in a case-control study of Costa Ricans living in the Central Valley of Costa Rica.
|
20927332 |
2010 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Evidence from multiple large prospective studies suggests that a common polymorphism that encodes an arginine (Arg)-to-tryptophan substitution at position 719 in the KIF6 gene is associated with coronary heart disease (CHD) and reduction in coronary events from statin therapy.
|
20854963 |
2010 |
|
Coronary Artery Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The KIF6 Trp719Arg polymorphism was not associated with the risk of clinical CAD in this large replication study.
|
20933357 |
2010 |
|
Myocardial Infarction
|
0.390 |
Biomarker
|
disease |
CTD_human |
[Association of a polymorphic marker Trp719Arg of KIF6 gene with effects of atorvastatin and simvastatin in patients with early ischemic heart disease].
|
21943003 |
2011 |
|
Myocardial Infarction
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
In summary, carriers of the KIF6 719Arg allele were not at increased risk of CAD/non-fatal MI in a case-control study of Indians (Indo-Europeans) living in Western India.
|
21810021 |
2011 |
|
Myocardial Infarction
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Of the 170 SNPs in the KIF6 region investigated in the Cholesterol and Recurrent Events trial (CARE), 28 were associated with differential event reduction from statin therapy (P (interaction) < 01 in Caucasians, adjusted for age and sex) and were further investigated in the Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction 22 (PROVE IT-TIMI22) and West of Scotland Coronary Prevention Study (WOSCOPS).
|
20886236 |
2011 |
|
Myocardial Infarction
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
The contribution of a 9p21.3 variant, a KIF6 variant, and C-reactive protein to predicting risk of myocardial infarction in a prospective study.
|
21406102 |
2011 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Investigation of KIF6 Trp719Arg in a case-control study of coronary artery disease in Western Indians.
|
21810021 |
2011 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A variant of KIF6 (719Arg) has also been reported to be associated with increased risk of CHD in large prospective studies, but not in case-control studies.
|
21406102 |
2011 |
|
Coronary heart disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Functional studies of these variants may help to understand the role of KIF6 in the pathogenesis of CHD and differential response to statin therapy.
|
20886236 |
2011 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Whereas six prospective studies have shown that carriers of the KIF6 Trp719Arg risk allele have 20% to 50% greater CHD risk than non-carriers, several cross-sectional case-control studies failed to show that carrier status is related to CHD.
|
21435211 |
2011 |