|
Myocardial Infarction
|
0.390 |
Biomarker
|
disease |
BEFREE |
The effect of kinesin family member 6 (KIF6) on statin therapy was also examined among patients who had a history of one or two heart attacks.
|
26443250 |
2015 |
|
Myocardial Infarction
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Our findings indicate that the Trp719Arg polymorphism of the KIF6 gene is an important risk factor for developing MI and that allele 719Arg may have a protective association to present CHD in all populations.
|
28096762 |
2015 |
|
Myocardial Infarction
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
A KIF6 variant in man has been reported to be associated with adverse cardiovascular outcomes after myocardial infarction.
|
23355886 |
2013 |
|
Myocardial Infarction
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
With regard to the primary CHD endpoint on trial (fatal or non-fatal myocardial infarction or stroke), we observed a significant relationship for KIF6 719Arg homozygotes (p=0.03, hazards ratio 0.47, 12.8% of the population) in women on pravastatin only, and for TAS2R50 for the AA genotype (p=0.03, hazards ratio 1.76, 8.9% of the population), also only in women on pravastatin.
|
22192511 |
2012 |
|
Myocardial Infarction
|
0.390 |
Biomarker
|
disease |
CTD_human |
[Association of a polymorphic marker Trp719Arg of KIF6 gene with effects of atorvastatin and simvastatin in patients with early ischemic heart disease].
|
21943003 |
2011 |
|
Myocardial Infarction
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
In summary, carriers of the KIF6 719Arg allele were not at increased risk of CAD/non-fatal MI in a case-control study of Indians (Indo-Europeans) living in Western India.
|
21810021 |
2011 |
|
Myocardial Infarction
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Of the 170 SNPs in the KIF6 region investigated in the Cholesterol and Recurrent Events trial (CARE), 28 were associated with differential event reduction from statin therapy (P (interaction) < 01 in Caucasians, adjusted for age and sex) and were further investigated in the Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction 22 (PROVE IT-TIMI22) and West of Scotland Coronary Prevention Study (WOSCOPS).
|
20886236 |
2011 |
|
Myocardial Infarction
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
The contribution of a 9p21.3 variant, a KIF6 variant, and C-reactive protein to predicting risk of myocardial infarction in a prospective study.
|
21406102 |
2011 |
|
Myocardial Infarction
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
We found that carriers of the KIF6 719Arg allele were not at increased risk of non-fatal MI in a case-control study of Costa Ricans living in the Central Valley of Costa Rica.
|
20927332 |
2010 |
|
Myocardial Infarction
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Confirming and extending previous reports, carriers of the 719Arg allele of KIF6 have 34% higher risk of myocardial infarction and 24% higher risk of CHD compared with noncarriers among 25,283 women from the WHS.
|
18222354 |
2008 |
|
Myocardial Infarction
|
0.390 |
GeneticVariation
|
disease |
LHGDN |
Confirming and extending previous reports, carriers of the 719Arg allele of KIF6 have 34% higher risk of myocardial infarction and 24% higher risk of CHD compared with noncarriers among 25,283 women from the WHS.
|
18222354 |
2008 |
|
Malignant neoplasm of breast
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There are no significant association found between KIF6 rs20455 polymorphism and CHD risk (Homozygote model: OR = 1.007, 95% CI =0.952-1.066, P = 0.801; Heterozygote model: OR = 1.009, 95% CI = 0.968-1.052, P = 0.636; Dominant model: OR = 1.007, 95% CI = 0.966-1.048, P = 0.753; Recessive model: OR = 0.989, 95% CI = 0.943-1.037, P = 0.655; Allele comparison model: OR = 1.00, 95% CI = 0.971-1.030, P = 0.988).
|
29304815 |
2018 |
|
Coronary Artery Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The KIF6 rs20455 polymorphism has been verified as an important genetic factor of coronary heart disease (CHD), but with controversial results.
|
29304815 |
2018 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Impact of KIF6 Polymorphism rs20455 on Coronary Heart Disease Risk and Effectiveness of Statin Therapy in 100 Patients from Southern Iran.
|
26443250 |
2015 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Studies and abstracts investigating the relationship between the Trp719Arg polymorphism of KIF6 and subsequent risk for development of CHD were reviewed.
|
28096762 |
2015 |
|
Coronary Artery Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Impact of KIF6 Polymorphism rs20455 on Coronary Heart Disease Risk and Effectiveness of Statin Therapy in 100 Patients from Southern Iran.
|
26443250 |
2015 |
|
Coronary Artery Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The Trp719Arg polymorphism of the KIF6 gene and coronary heart disease risk: systematic review and meta-analysis.
|
28096762 |
2015 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Novel KIF6 polymorphism increases susceptibility to type 2 diabetes mellitus and coronary heart disease in Han Chinese men.
|
25629058 |
2014 |
|
Dental caries of smooth surface
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.
|
24556642 |
2014 |
|
Coronary Artery Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Novel KIF6 polymorphism increases susceptibility to type 2 diabetes mellitus and coronary heart disease in Han Chinese men.
|
25629058 |
2014 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Meta-analyses of KIF6 Trp719Arg in coronary heart disease and statin therapeutic effect.
|
23236363 |
2012 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data indicate that the assessment of KIF6 rs20455 and TAS2R50 rs1376251 genotypes are not useful for predicting statin induced cardiovascular risk reduction in men, but do predict CHD risk reduction in women in this elderly population.
|
22192511 |
2012 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of KIF6 variant with lipid level and angiographic coronary artery disease events risk in the Han Chinese population.
|
23001387 |
2012 |