|
Prostate carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Coexpression of miR-15a and miR-375 resulted in downregulation of PHLPP1/2 and strongly increased prostate carcinoma cell growth.
|
24337069 |
2014 |
|
Prostate carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Accumulation of Phlpp1 and Deptor with corresponding inactivation of Akt/mTOR was also detected in Sag-null prostate cancer tissues.
|
27955654 |
2016 |
|
Prostate carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression.
|
21840483 |
2011 |
|
Prostate carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
In this study we have investigated the relationship between Usp12, PHLPP and PHLPPL tumour suppressors in the regulation of AR transcriptional activity in prostate cancer (PC).
|
25216524 |
2014 |
|
Liver carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Stable miR-190 overexpression leads to the downregulation of PHLPP1 protein expression. miR-190 has potential as a target in the treatment and diagnosis of HCC.
|
30092222 |
2018 |
|
Liver carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
The overexpressed PTENP1 decoyed oncomirs miR-17, miR-19b and miR-20a, which would otherwise target PTEN, PHLPP (a negative AKT regulator) and such autophagy genes as ULK1, ATG7 and p62, indicating that PTENP1 modulated the HCC cell behavior and gene networks by miRNA regulation.
|
25617127 |
2015 |
|
Liver carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The functional consequences of recombinant PHLPP1 overexpression in hepatoma HepG2 cells and L6 myoblasts were investigated.
|
21461637 |
2011 |
|
Liver carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Together, these results suggest that miR-367-3p may function as an AR enhancer to increase Sorafenib chemotherapy efficacy via altering the MDM2/AR/FKBP5/PHLPP/(pAKT and pERK) signals to better suppress HCC metastasis.
|
27688096 |
2016 |
|
Malignant tumor of colon
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our previous studies indicated a tumor suppressor role of both PHLPP isoforms in colon cancer.
|
21177869 |
2011 |
|
Malignant tumor of colon
|
0.030 |
Biomarker
|
disease |
BEFREE |
PHLPP, a novel family of Ser/Thr protein phosphatases, functions as a tumor suppressor in colon cancers.
|
24061475 |
2013 |
|
Malignant tumor of colon
|
0.030 |
Biomarker
|
disease |
BEFREE |
MiR-199a-5p and miR-375 affect colon cancer cell sensitivity to cetuximab by targeting PHLPP1.
|
26107137 |
2015 |
|
Colorectal Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Human CRC patient microarray data revealed that the expression of PHLPP1 or PHLPP2 is positively correlated with CDH1.
|
24530606 |
2014 |
|
Colorectal Carcinoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Importantly, we found a WDR48 somatic mutation (L580F) that is defective in stabilizing PHLPP1 in colorectal cancers, supporting a WDR48 role in tumor suppression.
|
24145035 |
2013 |
|
Colorectal Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
This study reveals functional and mechanistic links between miRNA-224 and the tumor suppressors PHLPP1 and PHLPP2 in the pathogenesis of colorectal cancer. miR-224 not only plays important roles in the regulation of cell proliferation and tumor growth in colorectal cancer, but also has potential as a prognostic marker or therapeutic target for colorectal cancer.
|
23846336 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
Biomarker
|
disease |
BEFREE |
PHLPP: a putative cellular target during insulin resistance and type 2 diabetes.
|
28428363 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Here we investigated the association of POL1-nearby variant rs488846, MALT1-nearby variant rs2874116, MC4R-nearby variant rs1942872, PHLPP rs9958800 and DSEL-nearby variant rs9966483 single nucleotide polymorphisms (SNPs) in the 18q region, previously linked with DN in African-Americans, with T2DM in (North African) Tunisian subjects, followed by their association with DN, which was performed subsequent to the analysis of the association with T2DM.
|
23727064 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
Biomarker
|
disease |
BEFREE |
These results suggest that several mechanisms affecting Akt isoforms, including deregulated production of PHLPP1, could underlie the alterations of skeletal muscle insulin signalling in type 2 diabetes.
|
18204829 |
2008 |
|
Malignant neoplasm of prostate
|
0.030 |
Biomarker
|
disease |
BEFREE |
Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression.
|
21840483 |
2011 |
|
Malignant neoplasm of prostate
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In this study we have investigated the relationship between Usp12, PHLPP and PHLPPL tumour suppressors in the regulation of AR transcriptional activity in prostate cancer (PC).
|
25216524 |
2014 |
|
Malignant neoplasm of prostate
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Accumulation of Phlpp1 and Deptor with corresponding inactivation of Akt/mTOR was also detected in Sag-null prostate cancer tissues.
|
27955654 |
2016 |
|
Diabetic Nephropathy
|
0.020 |
Biomarker
|
disease |
BEFREE |
Taken together, our results indicate that PHLPP1 up-surged Nrf2 nuclear instability by promoting Nrf2/β-TrCP association and its inhibition may be critical in the management of diabetic nephropathy.
|
29655866 |
2018 |
|
Diabetic Nephropathy
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Here we investigated the association of POL1-nearby variant rs488846, MALT1-nearby variant rs2874116, MC4R-nearby variant rs1942872, PHLPP rs9958800 and DSEL-nearby variant rs9966483 single nucleotide polymorphisms (SNPs) in the 18q region, previously linked with DN in African-Americans, with T2DM in (North African) Tunisian subjects, followed by their association with DN, which was performed subsequent to the analysis of the association with T2DM.
|
23727064 |
2013 |
|
Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The highest mean values of PHLPP1 mRNA and protein were found in non-glioma brain tissues whereas the lowest mean values were found in those in glioblastoma with an increase of TNF-α, IL-17, IL-1β (p<0.05).
|
26971226 |
2016 |
|
Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Restoring the localization of β-TrCP1 to the cytosol of glioblastoma cells rescues the ability of Akt to regulate PHLPP1 stability.
|
21454620 |
2011 |
|
melanoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We here show that PHLPP1 expression was significantly downregulated or lost and correlated with metastatic potential in melanoma.
|
29391600 |
2018 |