|
Tumor Progression
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Tumor progression and survival were analyzed in Phlpp1(-/-) Apc(Min) and Apc(Min)/Phlpp1(-/-) mice.
|
24530606 |
2014 |
|
Cardiac Arrest
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PHLPP1 levels increased in rat brains subjected to CA.
|
24023368 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PHLPP, a novel family of Ser/Thr protein phosphatases, functions as a tumor suppressor in colon cancers.
|
24061475 |
2013 |
|
Malignant tumor of colon
|
0.030 |
Biomarker
|
disease |
BEFREE |
PHLPP, a novel family of Ser/Thr protein phosphatases, functions as a tumor suppressor in colon cancers.
|
24061475 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
PHLPP1 expression in human glioma was associated negatively with the severity of the tumor and inflammatory cytokines. siRNA PHLPP1 could increase the levels of inflammatory cytokines in U251 glioma cells while PHLPP1 addition could inhibit significantly inflammatory cytokines.
|
26971226 |
2016 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
Biomarker
|
disease |
BEFREE |
PHLPP: a putative cellular target during insulin resistance and type 2 diabetes.
|
28428363 |
2017 |
|
Degenerative polyarthritis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Phlpp protein phosphatases are abnormally abundant within human osteoarthritic articular chondrocytes and may contribute to the development of osteoarthritis.
|
29068480 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PH domain leucine-rich repeat-containing protein phosphatase 1 (PHLPP1) is known to be a tumour suppressor.
|
30092222 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PHLPP1 (PH domain and leucine rich repeat protein phosphatase 1) is a newly identified family of Ser/Thr phosphatases that catalyzes the dephosphorylation of a conserved regulatory motif of the AGC kinases resulting in a tumor suppressive function, while CDKN1B/p27 also acts as a tumor suppressor by regulating cell cycle, senescence, apoptosis, and cell motility.
|
30821592 |
2019 |
|
Intervertebral Disc Degeneration
|
0.010 |
Biomarker
|
disease |
BEFREE |
Phlpp1 is associated with human intervertebral disc degeneration and its deficiency promotes healing after needle puncture injury in mice.
|
31582730 |
2019 |
|
Neoplasm Metastasis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
A lentiviral overexpression system was used to stably express miR-190, leading to the enhancement of hepatocellular carcinoma (HCC) proliferation and metastasis as a result of inhibited PHLPP1 expression.
|
30092222 |
2018 |
|
Squamous cell carcinoma of the hypopharynx
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Aberrant expression of PHLPP1 and PHLPP2 correlates with poor prognosis in patients with hypopharyngeal squamous cell carcinoma.
|
25793736 |
2015 |
|
Impaired insulin secretion
|
0.010 |
Biomarker
|
disease |
BEFREE |
Aberrations in PKB/AKT signaling coordinates with impaired insulin secretion and insulin resistance, identified during T2D, obesity and cardiovascular disorders which brings in the relevance of PHLPPs in the metabolic paradigm.
|
28428363 |
2017 |
|
Cardiovascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Aberrations in PKB/AKT signaling coordinates with impaired insulin secretion and insulin resistance, identified during T2D, obesity and cardiovascular disorders which brings in the relevance of PHLPPs in the metabolic paradigm.
|
28428363 |
2017 |
|
Prostate carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Accumulation of Phlpp1 and Deptor with corresponding inactivation of Akt/mTOR was also detected in Sag-null prostate cancer tissues.
|
27955654 |
2016 |
|
Malignant neoplasm of prostate
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Accumulation of Phlpp1 and Deptor with corresponding inactivation of Akt/mTOR was also detected in Sag-null prostate cancer tissues.
|
27955654 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
AKT signaling is constitutively activated in various cancers, due in large part to loss-of-function in the PTEN and PHLPP phosphatases that act as tumor suppressor genes.
|
23856247 |
2013 |
|
Neoplasm Metastasis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
AKT2 and AKT3 could even rescue the PHLPP1-mediated inhibition of metastasis.
|
29391600 |
2018 |
|
Malignant Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Altered Phlpp1 levels are associated with cancer and degenerative diseases such as osteoarthritis.
|
29775231 |
2018 |
|
Primary malignant neoplasm
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Altered Phlpp1 levels are associated with cancer and degenerative diseases such as osteoarthritis.
|
29775231 |
2018 |
|
Degenerative polyarthritis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Altered Phlpp1 levels are associated with cancer and degenerative diseases such as osteoarthritis.
|
29775231 |
2018 |
|
Colonic Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Apc(Min)/Phlpp1(-/-) mice had decreased survival and developed larger intestinal and colon tumors compared to Apc(Min) mice.
|
24530606 |
2014 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Both PHLPP1 and PHLPP2 are commonly deleted in human cancers, supporting a tumor suppressive role.
|
27913677 |
2016 |
|
Malignant Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt.
|
24703948 |
2014 |
|
Primary malignant neoplasm
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt.
|
24703948 |
2014 |