Colorectal Carcinoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Importantly, we found a WDR48 somatic mutation (L580F) that is defective in stabilizing PHLPP1 in colorectal cancers, supporting a WDR48 role in tumor suppression.
|
24145035 |
2013 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Here we investigated the association of POL1-nearby variant rs488846, MALT1-nearby variant rs2874116, MC4R-nearby variant rs1942872, PHLPP rs9958800 and DSEL-nearby variant rs9966483 single nucleotide polymorphisms (SNPs) in the 18q region, previously linked with DN in African-Americans, with T2DM in (North African) Tunisian subjects, followed by their association with DN, which was performed subsequent to the analysis of the association with T2DM.
|
23727064 |
2013 |
Diabetic Nephropathy
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Here we investigated the association of POL1-nearby variant rs488846, MALT1-nearby variant rs2874116, MC4R-nearby variant rs1942872, PHLPP rs9958800 and DSEL-nearby variant rs9966483 single nucleotide polymorphisms (SNPs) in the 18q region, previously linked with DN in African-Americans, with T2DM in (North African) Tunisian subjects, followed by their association with DN, which was performed subsequent to the analysis of the association with T2DM.
|
23727064 |
2013 |
Neoplastic Cell Transformation
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
miR-190-mediated downregulation of PHLPP contributes to arsenic-induced Akt activation and carcinogenesis.
|
21750348 |
2011 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The ability of miR-199a-5p and miR-375 to target PHLPP1 (PH domain and leucine-rich repeat protein phosphatase 1), a tumor suppressor that negatively regulates the AKT pathway, accounts, at least in part, for their drug-resistance activity.
|
26107137 |
2015 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PHLPP1 (PH domain and leucine rich repeat protein phosphatase 1) is a newly identified family of Ser/Thr phosphatases that catalyzes the dephosphorylation of a conserved regulatory motif of the AGC kinases resulting in a tumor suppressive function, while CDKN1B/p27 also acts as a tumor suppressor by regulating cell cycle, senescence, apoptosis, and cell motility.
|
30821592 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
It was PHLPP1 but not PHLPP2 that was significantly related to the tumor T stage.
|
25793736 |
2015 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this study we have investigated the relationship between Usp12, PHLPP and PHLPPL tumour suppressors in the regulation of AR transcriptional activity in prostate cancer (PC).
|
25216524 |
2014 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PH domain leucine-rich repeat-containing protein phosphatase 1 (PHLPP1) is known to be a tumour suppressor.
|
30092222 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together, our study identified a tumor suppressor role of PHLPP in suppressing cell motility by negatively regulating integrin expression in pancreatic cancer cells.
|
26760962 |
2016 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Whereas Apc(Min) mice developed mostly low-grade adenomas, 20% of the tumors that developed in Apc(Min)/Phlpp1(-/-) mice were invasive adenocarcinomas.
|
24530606 |
2014 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Rather, the defect arises from altered localization of β-TrCP1; in astrocytoma cell lines and in normal brain tissue the E3 ligase is predominantly cytoplasmic, whereas in glioblastoma cell lines and patient-derived tumor neurospheres, the E3 ligase is confined to the nucleus and thus spatially separated from PHLPP1, which is cytoplasmic.
|
21454620 |
2011 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PHLPP, a novel family of Ser/Thr protein phosphatases, functions as a tumor suppressor in colon cancers.
|
24061475 |
2013 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We show that Phlpp1-loss causes neoplasia and, on partial Pten-loss, carcinoma in mouse prostate.
|
21840483 |
2011 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our previous studies indicated a tumor suppressor role of both PHLPP isoforms in colon cancer.
|
21177869 |
2011 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1), which terminates Akt signaling by directly dephosphorylating and inactivating Akt, has been identified as a tumor suppressor.
|
22426999 |
2012 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This study reveals functional and mechanistic links between miRNA-224 and the tumor suppressors PHLPP1 and PHLPP2 in the pathogenesis of colorectal cancer. miR-224 not only plays important roles in the regulation of cell proliferation and tumor growth in colorectal cancer, but also has potential as a prognostic marker or therapeutic target for colorectal cancer.
|
23846336 |
2013 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
AKT signaling is constitutively activated in various cancers, due in large part to loss-of-function in the PTEN and PHLPP phosphatases that act as tumor suppressor genes.
|
23856247 |
2013 |
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Thus, PHLPP1 provides a proofreading step that maintains the fidelity of PKC autoinhibition and reveals a prominent loss-of-function mechanism in cancer by suppressing the steady-state levels of PKC.
|
30904392 |
2019 |
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
The frequent deletion of PHLPP in cancer, coupled with the development of prostate tumors in mice lacking PHLPP1, identifies PHLPP as a novel tumor suppressor.
|
22144674 |
2012 |
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Both PHLPP1 and PHLPP2 are commonly deleted in human cancers, supporting a tumor suppressive role.
|
27913677 |
2016 |
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Many factors regulate cancer cell apoptosis, among which Survivin has a strong anti-apoptotic effect and PHLPP is a tumor suppressor gene that can induce significant apoptosis.
|
25895131 |
2015 |
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
Thus, PHLPP1 provides a proofreading step that maintains the fidelity of PKC autoinhibition and reveals a prominent loss-of-function mechanism in cancer by suppressing the steady-state levels of PKC.
|
30904392 |
2019 |
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
The frequent deletion of PHLPP in cancer, coupled with the development of prostate tumors in mice lacking PHLPP1, identifies PHLPP as a novel tumor suppressor.
|
22144674 |
2012 |
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
Many factors regulate cancer cell apoptosis, among which Survivin has a strong anti-apoptotic effect and PHLPP is a tumor suppressor gene that can induce significant apoptosis.
|
25895131 |
2015 |