Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
|
19525953 |
2009 |
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
LHGDN |
The expanding genetic overlap between multiple sclerosis and type I diabetes.
|
18987646 |
2009 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Independent genome-wide association studies highlighted the function of CLEC16A/KIAA0350 polymorphisms modifying the risk to either multiple sclerosis (rs6498169) or type 1 diabetes (rs2903692).
|
19337309 |
2009 |
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Taken together these data provide evidence of joint disease association in T1D and MS within CLEC16A and underline a shared disease pathway.
|
18946483 |
2009 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
|
19525953 |
2009 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Of the 17 IMSGC SNPs, five SNPs showed genome-wide significant association with MS: HLA-DRA (P=8E-124), IL7R (P=6E-09), IL2RA (P=1E-11), CD58 (P=4E-09) and CLEC16A (P=3E-12).
|
19834503 |
2009 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Taken together these data provide evidence of joint disease association in T1D and MS within CLEC16A and underline a shared disease pathway.
|
18946483 |
2009 |
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
To dissect further the involvement of four recent identified MS susceptibility genes (KIAA0350, IL2RA, RPL5 and CD58) in disease pathogenesis, we genotyped 94 haplotype-tagging single nucleotide polymorphisms (SNPs) from these loci in 1146 MS cases and 1309 controls.
|
19375175 |
2009 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We also replicated several known MS associations (HLA-DR15, P = 7.0 x 10(-184); CD58, P = 9.6 x 10(-8); EVI5-RPL5, P = 2.5 x 10(-6); IL2RA, P = 7.4 x 10(-6); CLEC16A, P = 1.1 x 10(-4); IL7R, P = 1.3 x 10(-3); TYK2, P = 3.5 x 10(-3)) and observed a statistical interaction between SNPs in EVI5-RPL5 and HLA-DR15 (P = 0.001).
|
19525955 |
2009 |
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
CTD_human |
Taken together these data provide evidence of joint disease association in T1D and MS within CLEC16A and underline a shared disease pathway.
|
18946483 |
2009 |
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
CTD_human |
We also replicated several known MS associations (HLA-DR15, P = 7.0 x 10(-184); CD58, P = 9.6 x 10(-8); EVI5-RPL5, P = 2.5 x 10(-6); IL2RA, P = 7.4 x 10(-6); CLEC16A, P = 1.1 x 10(-4); IL7R, P = 1.3 x 10(-3); TYK2, P = 3.5 x 10(-3)) and observed a statistical interaction between SNPs in EVI5-RPL5 and HLA-DR15 (P = 0.001).
|
19525955 |
2009 |
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Furthermore, rs4774*C was associated with DRB1*1501+ MS when conditioned on the presence (OR = 1.67, 95% CI = 1.19-2.37, P = 1.9 x 10(-3)) and absence (OR = 1.49, 95% CI = 1.15-1.95, P = 2.3 x 10(-3)) of CLEC16A rs6498169*G, a putative MS risk allele adjacent to CIITA.
|
20211854 |
2010 |
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
For example, nucleotide variation in the interleukin 7 receptor (IL7RA), the interleukin 2 receptor (IL2RA), the CD58 and the c-type lectin domain family 16 member A (CLEC16A) genes has been consistently associated with MS in several populations.
|
20450971 |
2010 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
CLEC16A, a putative immunoreceptor, was recently established as a susceptibility locus for type I diabetes and multiple sclerosis.
|
20220768 |
2010 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Associations of CLEC16A polymorphisms with T1D and MS were successfully replicated in a Spanish population.
|
19221398 |
2010 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recent association studies in multiple sclerosis (MS) have identified and replicated several single nucleotide polymorphism (SNP) susceptibility loci including CLEC16A, IL2RA, IL7R, RPL5, CD58, CD40 and chromosome 12q13-14 in addition to the well established allele HLA-DR15.
|
20368992 |
2010 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
21833088 |
2011 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
|
21833088 |
2011 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
All described base polymorphisms are mapping to one LD block of approximately 50 kb within intron 19 of the CLEC16A gene, suggesting a pivotal role of this region for susceptibility of MS and possibly also for other autoimmune diseases.
|
20849399 |
2011 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA-CLEC16A-SOCS1 gene complex.
|
21653641 |
2011 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Two other SNPs were nominally associated with MS in this dataset, namely CLEC16A rs 12708716 (p = 0.0082, OR = 1.478, 95% CI = 1.106-1.975) and CD226 rs763361 (p = 0.03971, OR = 1.353, CI = 1.014-1.805).
|
20952449 |
2011 |
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
To explore the CLEC16A association in MS in more detail, we genotyped 57 SNPs in 807 Norwegian MS patients and 1027 Norwegian controls.
|
21179112 |
2011 |
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Multiple sclerosis (MS) shares some risk genes with other disorders hallmarked by an autoimmune pathogenesis, most notably IL2RA and CLEC16A.
|
22130326 |
2012 |
Multiple Sclerosis
|
0.500 |
Biomarker
|
disease |
BEFREE |
In reciprocal experiments, a 20 kb fragment of intron 19 of CLEC16A, containing SNPs associated with T1D and MS, as well as with DEXI expression, interacted with the promotor region of DEXI but not with candidate DNA fragments containing other potential causal genes in the region, including CLEC16A.
|
21989056 |
2012 |
Multiple Sclerosis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Multiple sclerosis-associated single-nucleotide polymorphisms in CLEC16A correlate with reduced SOCS1 and DEXI expression in the thymus.
|
23151489 |
2013 |