|
Dermatomyositis
|
0.210 |
Biomarker
|
disease |
MGD |
|
|
|
|
Dermatomyositis
|
0.210 |
Biomarker
|
disease |
BEFREE |
We propose that keratinocyte-derived Angptl2 functions in DM pathogenesis by inducing chronic inflammation in skin tissue.
|
22281496 |
2012 |
|
Malignant neoplasm of stomach
|
0.060 |
Biomarker
|
disease |
BEFREE |
Reduced expression of the insulin-induced protein 1 and p41 Arp2/3 complex genes in human gastric cancers.
|
12115587 |
2002 |
|
Malignant neoplasm of stomach
|
0.060 |
Biomarker
|
disease |
BEFREE |
Combined, these data demonstrate that Coronin3 can regulate GC invasion and metastasis through Arp2, and the combination of Coronin3 and Arp2 provides a potential marker for predicting GC prognosis.
|
24918434 |
2014 |
|
Malignant neoplasm of stomach
|
0.060 |
Biomarker
|
disease |
BEFREE |
Additionally, ANGPTL2 levels in the serum of gastric cancer patients were compared with those of healthy individuals to evaluate the possibility of the protein as a predictive biomarker for gastric cancer.
|
25484242 |
2015 |
|
Malignant neoplasm of stomach
|
0.060 |
Biomarker
|
disease |
BEFREE |
In clinical treatment, ANGPTL2 may become a new target for treatment of gastric cancer.
|
28058016 |
2016 |
|
Malignant neoplasm of stomach
|
0.060 |
Biomarker
|
disease |
BEFREE |
Additionally, a significant correlation was observed between the expression of Arpin and the presence of the Arp2/3 complex in GC tissues (<i>χ</i><sup>2</sup> = 30.535, <i>P</i> < 0.001).
|
28293092 |
2017 |
|
Malignant neoplasm of stomach
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
ANGPTL2 expression was upregulated in GC tissues compared to normal gastric mucosa; and high ANGPTL2 expression was significantly associated with tumor progression, early recurrence (P = 0.003) and poor prognosis (P = 0.007).
|
26420253 |
2015 |
|
Obesity
|
0.060 |
Biomarker
|
disease |
BEFREE |
Plasma angiopoietin-like 2 (Angptl2), a proinflammatory protein, has been associated with obesity and diabetes.
|
28754390 |
2017 |
|
Obesity
|
0.060 |
Biomarker
|
disease |
BEFREE |
Thus, Angptl2 is a key adipocyte-derived inflammatory mediator that links obesity to systemic insulin resistance.
|
19723494 |
2009 |
|
Obesity
|
0.060 |
Biomarker
|
disease |
BEFREE |
ANGPTL2 is known as an inflammatory mediator derived from adipose tissue that links obesity to systemic insulin resistance, and obestatin has been identified as a hormone associated with insulin resistance that suppresses food reabsorption, inhibits gastric emptying and decreases weight gain.
|
29932432 |
2018 |
|
Obesity
|
0.060 |
Biomarker
|
disease |
BEFREE |
These results suggest that the reduction of ANGPTL2 could be a useful and promising strategy to prevent obesity and insulin resistance, although further investigation of the mechanisms linking ANGPTL2 and intermittent fasting is warranted.
|
29192516 |
2018 |
|
Obesity
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
These findings may provide insight into the molecular mechanisms of the increased expression of Angptl2 and TGF-β1 in obesity.
|
23261458 |
2013 |
|
Obesity
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
To investigate the pattern and regulation of ANGPTL2 expression in human adipose tissues in obesity and its related diseases, we recruited 32 non-diabetic and 13 type 2 diabetic obese women and 32 normal-weight women.
|
30228336 |
2018 |
|
Malignant neoplasm of breast
|
0.050 |
Biomarker
|
disease |
BEFREE |
Arpin, a negative regulator of the actin-related protein-2/3 (Arp2/3) complex, is downregulated and predicts poor prognosis in breast cancer patients.
|
28531800 |
2017 |
|
Malignant neoplasm of breast
|
0.050 |
Biomarker
|
disease |
BEFREE |
This demonstrates that breast cancer can interact with the sensory nervous system to drive neuritogenesis through a VEGF-A/VEGFR2/ARP2/3 mediated pathway.
|
29100335 |
2017 |
|
Malignant neoplasm of breast
|
0.050 |
Biomarker
|
disease |
BEFREE |
Here, we show that tumor cell-derived angiopoietin-like protein 2 (ANGPTL2) increases responsiveness of breast cancer cells to CXCL12 by promoting up-regulation of CXCR4 in those cells.
|
25773070 |
2015 |
|
Malignant neoplasm of breast
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
This was further supported by decreased gene expression of extracellular matrix-degrading proteases (uPA, PLAT, ADAM8), cell adhesion molecules (integrins, laminins), pro-inflammatory mediators of the metastasis-promoting tumor microenvironment (TNFSF12, IL6, ANGPTL2, CSF1R) and concomitant increased expression of the validated breast cancer metastasis suppressor gene (BRMS1).
|
24498382 |
2014 |
|
Malignant neoplasm of breast
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Loss of the Arp2/3 inhibitory protein Arpin produces a similar poor outcome in breast cancer as high expression of the NCKAP1 subunit of the Arp2/3 activatory WAVE complex.
|
26867158 |
2016 |
|
Colorectal Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Likewise, serum ANGPTL2 levels in colorectal cancers were significantly higher than NCs (P < 0.01), and allowed distinguishing of colorectal cancers from NCs with high accuracy (AUC = 0.837).
|
25294915 |
2014 |
|
Colorectal Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Angiopoietin-like protein 2 negatively regulated by microRNA-25 contributes to the malignant progression of colorectal cancer.
|
25174582 |
2014 |
|
Colorectal Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Serum ANGPTL2 improves preoperative detection of LN metastasis in CRC.
|
25964566 |
2015 |
|
Colorectal Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
These results indicate that the colocalization of Arp2 and WAVE2 is an independent risk factor for liver metastasis of colorectal carcinoma.
|
17459058 |
2007 |
|
Colorectal Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Here, we explored that possibility by determining whether ANGPTL2 expression altered survival of human colorectal cancer cell lines treated with antineoplastic drugs.
|
25287946 |
2014 |
|
Diabetic Nephropathy
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
We studied the expression characteristics of angiopoietin-like 2 (ANGPTL2), a novel DN-associated growth factor identified in our previous gene chip screening.
|
17347581 |
2007 |