|
Diabetic Nephropathy
|
0.050 |
Biomarker
|
disease |
BEFREE |
ANGPTL2 knockdown alleviated renal injury in STZ-induced DN rat model.
|
28946139 |
2017 |
|
Diabetic Nephropathy
|
0.050 |
Biomarker
|
disease |
BEFREE |
Our recent study indicated that angiopoietin-like protein 2, which is a circulating proinflammatory protein, might be a strong mediator for the development of DKD and a good predictive biomarker of its progression.
|
30991405 |
2019 |
|
Diabetic Nephropathy
|
0.050 |
Biomarker
|
disease |
BEFREE |
ANGPTL2 might be directly involved in podocyte dysfunction and independently associated with the progression of DKD stages.
|
30137449 |
2019 |
|
Diabetic Nephropathy
|
0.050 |
Biomarker
|
disease |
BEFREE |
The present study aims to explore whether angiopoietin-like protein 2 (ANGPTL2) can promote renal tissue fibrosis in DN.
|
31632523 |
2019 |
|
Wiskott-Aldrich Syndrome
|
0.050 |
Biomarker
|
disease |
BEFREE |
When activated by Wiskott-Aldrich syndrome proteins (WASP), Arp2/3 complex nucleates branched actin filaments important for processes like cellular motility and endocytosis [1].
|
30471998 |
2018 |
|
Wiskott-Aldrich Syndrome
|
0.050 |
Biomarker
|
disease |
BEFREE |
ARPC1B-deficient platelets are microthrombocytes similar to those seen in Wiskott-Aldrich syndrome that show aberrant spreading consistent with loss of Arp2/3 function.
|
28368018 |
2017 |
|
Wiskott-Aldrich Syndrome
|
0.050 |
Biomarker
|
disease |
BEFREE |
TrkC activation led to a mobility shift of Wiskott-Aldrich syndrome family verprolin-homologous protein (WAVE)-2 which is known to orchestrate Arp2/3 activation and actin polymerization.
|
29162704 |
2018 |
|
Wiskott-Aldrich Syndrome
|
0.050 |
Biomarker
|
disease |
BEFREE |
We discover a key biochemical difference between Dip1 and WASP that may limit linear filament nucleation in cells; although WASP must be released for nucleation, Dip1 stays associated with Arp2/3 complex on the pointed ends of nucleated actin filaments, so Dip1 is consumed in the reaction.
|
31564494 |
2019 |
|
Wiskott-Aldrich Syndrome
|
0.050 |
Biomarker
|
disease |
BEFREE |
We have used both the acidic domains from actin-related protein (Arp) 2/3 complex-binding proteins such as the Wiscott-Aldrich syndrome protein (N-WASP) or cortactin, and siRNA directing toward Arp2 to inhibit viral infection.
|
15385624 |
2004 |
|
Breast Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Loss of the Arp2/3 inhibitory protein Arpin produces a similar poor outcome in breast cancer as high expression of the NCKAP1 subunit of the Arp2/3 activatory WAVE complex.
|
26867158 |
2016 |
|
Breast Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
This was further supported by decreased gene expression of extracellular matrix-degrading proteases (uPA, PLAT, ADAM8), cell adhesion molecules (integrins, laminins), pro-inflammatory mediators of the metastasis-promoting tumor microenvironment (TNFSF12, IL6, ANGPTL2, CSF1R) and concomitant increased expression of the validated breast cancer metastasis suppressor gene (BRMS1).
|
24498382 |
2014 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Here, we show that tumor cell-derived angiopoietin-like protein 2 (ANGPTL2) increases responsiveness of breast cancer cells to CXCL12 by promoting up-regulation of CXCR4 in those cells.
|
25773070 |
2015 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
This demonstrates that breast cancer can interact with the sensory nervous system to drive neuritogenesis through a VEGF-A/VEGFR2/ARP2/3 mediated pathway.
|
29100335 |
2017 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Arpin, a negative regulator of the actin-related protein-2/3 (Arp2/3) complex, is downregulated and predicts poor prognosis in breast cancer patients.
|
28531800 |
2017 |
|
Stomach Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Combined, these data demonstrate that Coronin3 can regulate GC invasion and metastasis through Arp2, and the combination of Coronin3 and Arp2 provides a potential marker for predicting GC prognosis.
|
24918434 |
2014 |
|
Stomach Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Additionally, a significant correlation was observed between the expression of Arpin and the presence of the Arp2/3 complex in GC tissues (<i>χ</i><sup>2</sup> = 30.535, <i>P</i> < 0.001).
|
28293092 |
2017 |
|
Stomach Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
In clinical treatment, ANGPTL2 may become a new target for treatment of gastric cancer.
|
28058016 |
2016 |
|
Stomach Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Additionally, ANGPTL2 levels in the serum of gastric cancer patients were compared with those of healthy individuals to evaluate the possibility of the protein as a predictive biomarker for gastric cancer.
|
25484242 |
2015 |
|
Stomach Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
ANGPTL2 expression was upregulated in GC tissues compared to normal gastric mucosa; and high ANGPTL2 expression was significantly associated with tumor progression, early recurrence (P = 0.003) and poor prognosis (P = 0.007).
|
26420253 |
2015 |
|
Diabetes
|
0.040 |
Biomarker
|
disease |
BEFREE |
This study aimed to explore the role of ANGPTL2 in adipose tissue inflammation and macrophage activation in a mouse model of diabetes.
|
26132105 |
2015 |
|
Diabetes
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Different observational clinical studies reported that circulating levels of ANGPTL2 increase significantly in various chronic inflammatory diseases and showed associations between ANGPTL2 levels and diagnosis and/or prognosis of cardiovascular diseases, diabetes, chronic kidney disease, and various types of cancers.
|
29138671 |
2017 |
|
Diabetes
|
0.040 |
Biomarker
|
disease |
BEFREE |
Plasma angiopoietin-like 2 (Angptl2), a proinflammatory protein, has been associated with obesity and diabetes.
|
28754390 |
2017 |
|
Diabetes
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
To examine the role of ANGPTL2 in the pathogenesis of diabetic kidney disease (DKD), we studied the epigenetic regulation of angptl2 expression in patients with diabetes.
|
30137449 |
2019 |
|
Glioma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Inhibition of the Arp2/3 complex significantly affected the ability of glioma cells to migrate and invade.
|
23969835 |
2013 |
|
Glioma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Taken together, our study provided the first evidence that ANGPTL2 played an oncogenic role in glioma development and might be considered as a new therapeutic target for glioma treatment.
|
28247845 |
2017 |