|
Alzheimer's Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Western blotting detected reduced Arp2 levels in the AD group, but there was no correlation with phosphorylated tau levels suggesting that the Arp2 loss does not contribute to mechanisms that drive tau pathology progression.
|
31410926 |
2020 |
|
Down Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Fluorescent deconvolution tomography was used to determine postsynaptic PAK3 and Arp2 levels for large numbers of excitatory synapses in the parietal cortex of individuals with DS plus AD pathology (DS + AD) or AD alone relative to age-matched controls.
|
31410926 |
2020 |
|
Impaired cognition
|
0.010 |
Biomarker
|
disease |
BEFREE |
As both PAK and the Arp2/3 complex play roles in the actin stabilization that supports synaptic plasticity, reductions in these proteins at synapses may be early events in spine dysfunction that contribute to cognitive impairment in these disorders.
|
31410926 |
2020 |
|
Complete Trisomy 21 Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Fluorescent deconvolution tomography was used to determine postsynaptic PAK3 and Arp2 levels for large numbers of excitatory synapses in the parietal cortex of individuals with DS plus AD pathology (DS + AD) or AD alone relative to age-matched controls.
|
31410926 |
2020 |
|
Malignant neoplasm of thyroid
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Correlations of ANGPTL2 expression levels with proliferation, migration, and metastasis of thyroid cancer were assessed with the TCGA data set and analyzed by gene set enrichment analysis.
|
31384179 |
2019 |
|
Japanese Encephalitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Membrane trafficking RNA interference screen identifies a crucial role of the clathrin endocytic pathway and ARP2/3 complex for Japanese encephalitis virus infection in HeLa cells.
|
30489239 |
2019 |
|
Hyperglycemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Elevated serum ANGPTL2 associated with 2.83-fold increased risk of T2D and with 1.18-fold elevated risk of CVD among T2D patients with positive correlations with markers of hyperglycemia, insulin resistance and atherogenic lipid profile.
|
31484627 |
2019 |
|
Liver Cirrhosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The serum ANGPTL2 displayed better diagnostic efficiency not only for differentiating HCC from HC but also for differentiating HCC from high-risk controls (CHB+LC).
|
31534368 |
2019 |
|
melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we conducted mechanistic analysis comparing ANGPTL2 function in cancer progression in a murine syngeneic model of melanoma and a mouse model of translocation renal cell carcinoma (tRCC).
|
31727773 |
2019 |
|
Myocardial Infarction
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression level of Angptl 2 and IL-6 in the myocardial infarction group was significantly higher than that in the control group P<0.001.
|
30988729 |
2019 |
|
Degenerative polyarthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Next, human primary chondrocytes were treated with IL-1β to mimic OA progress in vitro, and the expression of ANGPTL2 were tested by qRT-PCR and western blot.
|
31214838 |
2019 |
|
Thyroid Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Correlations of ANGPTL2 expression levels with proliferation, migration, and metastasis of thyroid cancer were assessed with the TCGA data set and analyzed by gene set enrichment analysis.
|
31384179 |
2019 |
|
Complete atrioventricular block
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
As shown in our previous studies, ANGPTL2 expression positively correlates with liver fibrosis stages in chronic hepatitis B (CHB) patients.
|
31534368 |
2019 |
|
Renal fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
ANGPTL2 may serve an important role in the autophagy of DN and activate MEK/ERK/Nrf-1 pathway, which may therefore have potential as a treatment to prevent renal fibrosis in DN.
|
31632523 |
2019 |
|
Malignant neoplasm of mouth
|
0.010 |
Biomarker
|
group |
BEFREE |
We review its molecular structure, its most important interactions (with Src, Arp2/3 complex, and SH3-binding partners), the regulation of its functions, and its specific oncogenic role in oral cancer.
|
29878474 |
2019 |
|
Lip and Oral Cavity Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We review its molecular structure, its most important interactions (with Src, Arp2/3 complex, and SH3-binding partners), the regulation of its functions, and its specific oncogenic role in oral cancer.
|
29878474 |
2019 |
|
Papillary thyroid carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The level of ANGPTL2 in PTC and para-cancerous tissue was assessed by immunohistochemistry.
|
31384179 |
2019 |
|
Fibrosis, Liver
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
As shown in our previous studies, ANGPTL2 expression positively correlates with liver fibrosis stages in chronic hepatitis B (CHB) patients.
|
31534368 |
2019 |
|
Coronary Stenosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Pearson's correlation analysis showed that Angptl 2 and IL-6 were positively correlated with the diameter of coronary stenosis (r=0.696, 0.750, P<0.001).
|
30988729 |
2019 |
|
Combined immunodeficiency
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Patients with mutations in the actin-related protein complex 1B (ARPC1B) subunit of Arp2/3 show combined immunodeficiency, with symptoms of immune dysregulation, including recurrent viral infections and reduced CD8+ T cell count.
|
31710310 |
2019 |
|
Hepatitis B, Chronic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
As shown in our previous studies, ANGPTL2 expression positively correlates with liver fibrosis stages in chronic hepatitis B (CHB) patients.
|
31534368 |
2019 |
|
Thyroid carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Correlations of ANGPTL2 expression levels with proliferation, migration, and metastasis of thyroid cancer were assessed with the TCGA data set and analyzed by gene set enrichment analysis.
|
31384179 |
2019 |
|
Acute Chest Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
It is reported that DNA hypomethylation in the promoter region of ANGPTL2 gene was associated with acute coronary syndrome (ACS), a type of CHD.
|
30461060 |
2019 |
|
Tumor Promotion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Our study provides strong evidence that ANGPTL2 can function in either tumor promotion or suppression, depending on what cell type it is expressed in.
|
31727773 |
2019 |
|
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results of the receiver operating characteristic curve indicated a significantly higher area under the curve for the ability of the ANGPTL2 to predict HCC than alpha fetoprotein (AFP).
|
31534368 |
2019 |