|
MiT family translocation renal cell carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, systemic ablation of ANGPTL2 accelerated tRCC progression, supporting a tumor-suppressing role.
|
31727773 |
2019 |
|
Osteopenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, our study indicated that ANGPTL2 played an essential role in osteoclast generation through regulating the proliferation and inflammation of osteoclast lineage cells, providing new insights into the therapeutic strategy to alleviate bone loss.
|
30031603 |
2018 |
|
Osteoporosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In vivo, we confirmed that ANGPTL2 knockout (KO) mice were protected against osteoporosis induced by ovariectomy (OVX), as proved by the improved bone loss and bone mineral density (BMD).
|
30031603 |
2018 |
|
Respiratory Distress Syndrome, Adult
|
0.010 |
Biomarker
|
disease |
BEFREE |
HARP-2 was a multicentre, randomised controlled trial of simvastatin (80 mg) versus placebo done in general intensive care units (ICUs) at 40 hospitals in the UK and Ireland within 48 h of onset of ARDS.
|
30078618 |
2018 |
|
Cervical Intraepithelial Neoplasia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Cervical intraepithelial neoplasia (CIN) in African women living with HIV: role and effect of rigorous histopathological review by a panel of pathologists in the HARP study endpoint determination.
|
28600294 |
2018 |
|
Transitional cell carcinoma of bladder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Logistic regression analysis demonstrated that Arp2 expression was an independent risk factor for lymph node metastasis of BUC (<i>P</i> < 0.05).
|
29593429 |
2018 |
|
Amputated structure (morphologic abnormality)
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
History of PAD (HR 4.37 95% CI [2.11-9.07]; p < 0.001), severe diabetic retinopathy (2.69 [1.31-5.57]; p = 0.0073), male gender (10.12 [2.41-42.56]; p = 0.0016) and serum ANGPTL2 concentrations (1.25 [1.08-1.45]; p = 0.0025) were associated with minor amputation outcome.
|
29879997 |
2018 |
|
Non-alcoholic Fatty Liver Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
The effects of ANGPTL2 and ANGPTL6 in the pathogenesis of NAFLD should be investigated further.
|
30002695 |
2018 |
|
Sarcopenia
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
In conclusion, ANGPTL2 up-regulation in skeletal myocytes accelerates muscle atrophy, and exercise-induced attenuation of ANGPTL2 expression in those tissues may partially explain how exercise training prevents sarcopenia.
|
29191837 |
2018 |
|
Peripheral Arterial Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
History of PAD (HR 4.37 95% CI [2.11-9.07]; p < 0.001), severe diabetic retinopathy (2.69 [1.31-5.57]; p = 0.0073), male gender (10.12 [2.41-42.56]; p = 0.0016) and serum ANGPTL2 concentrations (1.25 [1.08-1.45]; p = 0.0025) were associated with minor amputation outcome.
|
29879997 |
2018 |
|
Malignant tumor of colon
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our study shows that glucocorticoids reduced prostanoids, urokinase-type plasminogen activator (uPA) and angiopoietin-like protein-2 (ANGPTL2) levels, but increased angiogenin (ANG) in supernatant from human CT5.3hTERT colon cancer-derived myofibroblasts.
|
27717848 |
2017 |
|
Heart Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Overall, ANGPTL2 autocrine/paracrine signaling is a new factor in accelerating heart disease development in the aging.
|
28867689 |
2017 |
|
Periodontal Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
We hypothesized that ANGPTL2 might play an important role as a unique mediator in both systemic and periodontal disease.
|
28934245 |
2017 |
|
Periodontitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Via this pathway, ANGPTL2 functions in the pathogenesis of periodontitis and contributes to prolonging chronic inflammation in patients with systemic disease.
|
28934245 |
2017 |
|
Skin Abnormalities
|
0.010 |
Biomarker
|
group |
BEFREE |
We found that depletion of the Arp2/3 complex by knockout of <i>Arpc4</i> results in skin abnormalities at birth that evolve into a severe psoriasis-like disease hallmarked by hyperactivation of transcription factor Nrf2.
|
29113991 |
2017 |
|
Colon Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our study shows that glucocorticoids reduced prostanoids, urokinase-type plasminogen activator (uPA) and angiopoietin-like protein-2 (ANGPTL2) levels, but increased angiogenin (ANG) in supernatant from human CT5.3hTERT colon cancer-derived myofibroblasts.
|
27717848 |
2017 |
|
Chronic Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Circulating ANGPTL2 is increased in chronic kidney disease (CKD), where the risk of CVD is amplified.
|
28158589 |
2017 |
|
LAURIN-SANDROW SYNDROME
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The comparative analysis of mRNA expression levels (LSS vs LDH) failed to show significant differences in TGF-β1 (p = 0.08); however, we found a significant positive correlation among ANGPTL2, VEGF, TGF-β1, and collagen-1 and 3, which represent common trends in hypertrophic activity (p < 0.05).
|
28180980 |
2017 |
|
Aortic Stiffness
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The objectives of the present study were to (i) examine whether kidney transplantation (KTx) reduces ANGPTL2 levels, (ii) identify the determinants of ANGPTL2 after KTx, (iii) study the association of ANGPTL2 with aortic stiffness, and (iv) assess the impact of ANGPTL2 on mortality after KTx.
|
28158589 |
2017 |
|
Age related macular degeneration
|
0.010 |
Biomarker
|
disease |
BEFREE |
Angptl2 might therefore represent a multistep regulator of CNV pathogenesis and serve as a new therapeutic target for age-related macular degeneration.
|
26839315 |
2016 |
|
Esophageal Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
ANGPTL2 expression in EC tissues was significantly elevated in patients with a high T stage, squamous cell carcinoma, and high TNM stage.
|
25564164 |
2015 |
|
Nodule
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Nodule formation is dependent on Wiskott-Aldrich syndrome protein (WASp) and the ARP2/3 complex.
|
26028144 |
2015 |
|
Esophageal carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ANGPTL2 expression in EC tissues was significantly elevated in patients with a high T stage, squamous cell carcinoma, and high TNM stage.
|
25564164 |
2015 |
|
Secondary malignant neoplasm of bone
|
0.010 |
Biomarker
|
disease |
BEFREE |
We conclude that tumor cell-derived ANGPTL2 may increase bone metastasis by enhancing breast tumor cell responsiveness to CXCL12 signaling through up-regulation of tumor cell CXCR4 expression.
|
25773070 |
2015 |
|
Spinal stenosis of lumbar region
|
0.010 |
Biomarker
|
disease |
BEFREE |
Angiopoietin-like protein 2 promotes inflammatory conditions in the ligamentum flavum in the pathogenesis of lumbar spinal canal stenosis by activating interleukin-6 expression.
|
25735609 |
2015 |