|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Angiopoietin-like protein 2 (ANGPTL2) is a secreted molecule with numerous physiologic and pathologic functions, for example, in angiogenesis, hematopoiesis, and tumorigenesis.
|
31581797 |
2019 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Angiopoietin-like protein 2 (ANGPTL2) plays an important role in inflammatory carcinogenesis and tumor metastasis by activating tumor angiogenesis and tumor cell chemotaxis and invasiveness.
|
25287946 |
2014 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
As angiopoietin-like protein 2 (ANGPTL2) mediates inflammation and inflammation-associated carcinogenesis, we investigated the functional and clinical significance of ANGPTL2 in human gastric cancer (GC).
|
26420253 |
2015 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Angiopoietin-like protein 2 (ANGPTL2) is a mediator of chronic inflammation and inflammatory carcinogenesis.
|
25294915 |
2014 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Moreover, the tumorigenesis assay showed that ANGPTL2 knockdown inhibited glioma tumor growth in vivo.
|
28247845 |
2017 |
|
Carcinogenesis
|
0.060 |
PosttranslationalModification
|
phenotype |
BEFREE |
These results suggest that, at least partly, epigenetic silencing by hypermethylation of the ANGPTL2 promoter leads to a loss of ANGPTL2 function, which may be a factor in the carcinogenesis of OC in a stage-dependent manner.
|
18593905 |
2008 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
These results suggest that, at least partly, epigenetic silencing by hypermethylation of the ANGPTL2 promoter leads to a loss of ANGPTL2 function, which may be a factor in the carcinogenesis of OC in a stage-dependent manner.
|
18593905 |
2008 |
|
Cardiovascular Diseases
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Histological analysis revealed abundant Angptl2 expression in endothelial cells and macrophages infiltrating atheromatous plaques in patients with cardiovascular disease.
|
24526691 |
2014 |
|
Cardiovascular Diseases
|
0.060 |
Biomarker
|
group |
BEFREE |
We indicate for the first time serum ANGPTL2 as an independent risk biomarker for CVD in T2D patients.
|
31484627 |
2019 |
|
Cardiovascular Diseases
|
0.060 |
Biomarker
|
group |
BEFREE |
Circulating ANGPTL2 is increased in chronic kidney disease (CKD), where the risk of CVD is amplified.
|
28158589 |
2017 |
|
Cardiovascular Diseases
|
0.060 |
Biomarker
|
group |
BEFREE |
Overall, our studies demonstrate that perivascular adipose tissue-secreted Angptl2 accelerates vascular inflammation and the subsequent CVD development.
|
23333801 |
2013 |
|
Cardiovascular Diseases
|
0.060 |
AlteredExpression
|
group |
BEFREE |
A strong relationship between high circulating angiopoietin-like 2 (ANGPTL2) levels, a proinflammatory adipokine, and cardiovascular diseases has been reported.
|
30745045 |
2019 |
|
Cardiovascular Diseases
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Different observational clinical studies reported that circulating levels of ANGPTL2 increase significantly in various chronic inflammatory diseases and showed associations between ANGPTL2 levels and diagnosis and/or prognosis of cardiovascular diseases, diabetes, chronic kidney disease, and various types of cancers.
|
29138671 |
2017 |
|
Cervical Intraepithelial Neoplasia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Cervical intraepithelial neoplasia (CIN) in African women living with HIV: role and effect of rigorous histopathological review by a panel of pathologists in the HARP study endpoint determination.
|
28600294 |
2018 |
|
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
HARPΔ111-136 enhances radiation-induced apoptosis of U87MG glioblastoma by induction of the proapoptotic protein CHOP.
|
21109939 |
2011 |
|
Childhood Osteosarcoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Experiments <i>in vivo</i> were performed to value the effects of Angptl2 on the growth of osteosarcoma xenografts in mice.
|
31737187 |
2019 |
|
Childhood Osteosarcoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
ANGPTL2 expression in OS cell lines correlated with increased tumor metastasis and decreased animal survival by promoting tumor cell intravasation mediated by the integrin α5β1, p38 mitogen-activated protein kinase, and matrix metalloproteinases.
|
24448647 |
2014 |
|
Chronic Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Circulating ANGPTL2 is increased in chronic kidney disease (CKD), where the risk of CVD is amplified.
|
28158589 |
2017 |
|
Colon Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our study shows that glucocorticoids reduced prostanoids, urokinase-type plasminogen activator (uPA) and angiopoietin-like protein-2 (ANGPTL2) levels, but increased angiogenin (ANG) in supernatant from human CT5.3hTERT colon cancer-derived myofibroblasts.
|
27717848 |
2017 |
|
Colorectal Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Likewise, serum ANGPTL2 levels in colorectal cancers were significantly higher than NCs (P < 0.01), and allowed distinguishing of colorectal cancers from NCs with high accuracy (AUC = 0.837).
|
25294915 |
2014 |
|
Colorectal Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Angiopoietin-like protein 2 negatively regulated by microRNA-25 contributes to the malignant progression of colorectal cancer.
|
25174582 |
2014 |
|
Colorectal Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Serum ANGPTL2 improves preoperative detection of LN metastasis in CRC.
|
25964566 |
2015 |
|
Colorectal Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
These results indicate that the colocalization of Arp2 and WAVE2 is an independent risk factor for liver metastasis of colorectal carcinoma.
|
17459058 |
2007 |
|
Colorectal Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Here, we explored that possibility by determining whether ANGPTL2 expression altered survival of human colorectal cancer cell lines treated with antineoplastic drugs.
|
25287946 |
2014 |
|
Combined immunodeficiency
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Patients with mutations in the actin-related protein complex 1B (ARPC1B) subunit of Arp2/3 show combined immunodeficiency, with symptoms of immune dysregulation, including recurrent viral infections and reduced CD8+ T cell count.
|
31710310 |
2019 |