ANGPTL2, angiopoietin like 2, 23452

N. diseases: 125; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0494165
Disease: Secondary malignant neoplasm of liver
Secondary malignant neoplasm of liver 		0.030 AlteredExpression disease BEFREE ANGPTL2 was overexpressed in colorectal cancer tissues, and was significantly associated with advanced T stage, lymph node, and liver metastasis. 25294915 2014
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms 		0.010 AlteredExpression group BEFREE ANGPTL2 expression in EC tissues was significantly elevated in patients with a high T stage, squamous cell carcinoma, and high TNM stage. 25564164 2015
CUI: C0152018
Disease: Esophageal carcinoma
Esophageal carcinoma 		0.010 AlteredExpression disease BEFREE ANGPTL2 expression in EC tissues was significantly elevated in patients with a high T stage, squamous cell carcinoma, and high TNM stage. 25564164 2015
CUI: C0546837
Disease: Malignant neoplasm of esophagus
Malignant neoplasm of esophagus 		0.010 AlteredExpression disease BEFREE ANGPTL2 expression in EC tissues was significantly elevated in patients with a high T stage, squamous cell carcinoma, and high TNM stage. 25564164 2015
CUI: C0158288
Disease: Spinal stenosis of lumbar region
Spinal stenosis of lumbar region 		0.010 Biomarker disease BEFREE Angiopoietin-like protein 2 promotes inflammatory conditions in the ligamentum flavum in the pathogenesis of lumbar spinal canal stenosis by activating interleukin-6 expression. 25735609 2015
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.060 AlteredExpression disease BEFREE ANGPTL2 expression was upregulated in GC tissues compared to normal gastric mucosa; and high ANGPTL2 expression was significantly associated with tumor progression, early recurrence (P = 0.003) and poor prognosis (P = 0.007). 26420253 2015
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.050 AlteredExpression disease BEFREE ANGPTL2 expression was upregulated in GC tissues compared to normal gastric mucosa; and high ANGPTL2 expression was significantly associated with tumor progression, early recurrence (P = 0.003) and poor prognosis (P = 0.007). 26420253 2015
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.070 AlteredExpression phenotype BEFREE ANGPTL2 expression was upregulated in GC tissues compared to normal gastric mucosa; and high ANGPTL2 expression was significantly associated with tumor progression, early recurrence (P = 0.003) and poor prognosis (P = 0.007). 26420253 2015
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.010 Biomarker disease BEFREE Angptl2 might therefore represent a multistep regulator of CNV pathogenesis and serve as a new therapeutic target for age-related macular degeneration. 26839315 2016
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		0.030 Biomarker disease BEFREE ANGPTL2 is a circulating pro-inflammatory protein that increases with age and prematurely in patients with coronary artery diseases; integrating the methylation pattern of the promoter may help differentiate age- vs. disease-related change in its expression. 27101308 2016
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.020 Biomarker disease BEFREE ANGPTL2 is a circulating pro-inflammatory protein that increases with age and prematurely in patients with coronary artery diseases; integrating the methylation pattern of the promoter may help differentiate age- vs. disease-related change in its expression. 27101308 2016
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.100 Biomarker phenotype BEFREE ANGPTL2 contributed to proliferation and invasion of gastric cancer cells. 28058016 2016
CUI: C0856169
Disease: Endothelial dysfunction
Endothelial dysfunction 		0.020 Biomarker phenotype BEFREE Angiopoietin-like-2 (ANGPTL2) is a secreted proinflammatory glycoprotein that promotes endothelial dysfunction, atherosclerosis, and cardiovascular disease (CVD). 28158589 2017
CUI: C1290884
Disease: Inflammatory disorder
Inflammatory disorder 		0.020 Biomarker group BEFREE Angiopoietin-like protein 2 (ANGPTL2) was reported to be implicated in the pathogenesis of inflammatory disease. 28946139 2017
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.050 Biomarker disease BEFREE ANGPTL2 knockdown alleviated renal injury in STZ-induced DN rat model. 28946139 2017
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.070 Biomarker phenotype BEFREE Angiopoietin-like protein 2 (Angptl2) is involved in tumor progression. 29218246 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE Arp2 expression in BUC tissues was associated with tumor size, tumor multiplicity, tumor stage, tumor grade, and lymph node metastasis (<i>P</i> < 0.05). 29593429 2018
CUI: C0028754
Disease: Obesity
Obesity 		0.060 Biomarker disease BEFREE ANGPTL2 is known as an inflammatory mediator derived from adipose tissue that links obesity to systemic insulin resistance, and obestatin has been identified as a hormone associated with insulin resistance that suppresses food reabsorption, inhibits gastric emptying and decreases weight gain. 29932432 2018
CUI: C0035222
Disease: Respiratory Distress Syndrome, Adult
Respiratory Distress Syndrome, Adult 		0.010 Biomarker disease BEFREE HARP-2 was a multicentre, randomised controlled trial of simvastatin (80 mg) versus placebo done in general intensive care units (ICUs) at 40 hospitals in the UK and Ireland within 48 h of onset of ARDS. 30078618 2018
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.050 Biomarker disease BEFREE ANGPTL2 might be directly involved in podocyte dysfunction and independently associated with the progression of DKD stages. 30137449 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE Arp2/3 specificity may thus provide diagnostic and therapeutic opportunities in cancer. 30971746 2019
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 Biomarker group BEFREE Arp2/3 specificity may thus provide diagnostic and therapeutic opportunities in cancer. 30971746 2019
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.070 Biomarker phenotype BEFREE Arp2/3 inhibition has recently garnered more attention as it has been associated with attenuation of cancer progression, neurotoxic effects during drug abuse, and pathogen invasion of host cells. 31073744 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE Angiopoietin-like 2 (ANGPTL2), a secreted protein which belongs to the angiopoietin (ANGPTL) family, was reported to be involved in the regulation of several different type of cancer cell proliferation and metastasis. 31384179 2019
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 Biomarker group BEFREE Angiopoietin-like 2 (ANGPTL2), a secreted protein which belongs to the angiopoietin (ANGPTL) family, was reported to be involved in the regulation of several different type of cancer cell proliferation and metastasis. 31384179 2019