Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Moreover, this case had a t(1;2) translocation fusing ALK and TMP3, identical to that seen in inflammatory myofibroblastic tumour.
|
27450657 |
2016 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Here we report the identification of a secondary mutation in ALK, F1174L, as one cause of crizotinib resistance in a patient with an inflammatory myofibroblastic tumor (IMT) harboring a RANBP2-ALK translocation who progressed while on crizotinib therapy.
|
21030459 |
2010 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Anaplastic lymphoma kinase (ALK) gene rearrangements, most often resulting in the tropomyosin 3 (TPM3)-ALK fusion gene, are the main causes of IMT.
|
25596129 |
2015 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Neoadjuvant crizotinib in advanced inflammatory myofibroblastic tumour with ALK gene rearrangement.
|
25744866 |
2015 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Molecular characterization of inflammatory myofibroblastic tumors with frequent ALK and ROS1 gene fusions and rare novel RET rearrangement.
|
25723109 |
2015 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Inflammatory myofibroblastic tumor (IMT) is a rare benign cancer that can express a more aggressive phenotype related to the genetic mutation of the anaplastic lymphoma kinase receptor (ALK).
|
30900517 |
2019 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Epithelioid inflammatory myofibroblastic sarcoma is a variant of inflammatory myofibroblastic tumor with aggressive clinical course associated with RANBP2-ALK fusion.
|
25028698 |
2014 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
RANBP2 and CLTC are involved in ALK rearrangements in inflammatory myofibroblastic tumors.
|
17656252 |
2007 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
All 14 IMTs were confirmed to harbor ALK genetic fusion by RNA sequencing, and ALK immunostaining in the form of granular cytoplasmic positivity with paranuclear accentuation was observed in all 14 cases.
|
30015720 |
2018 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Some populations of IMT have anaplastic large cell lymphoma kinase (ALK) gene rearrangements.
|
16984614 |
2006 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Even on re-review the IMT in these 2 cases were morphologically indistinguishable from other cases of IMT, with FISH demonstrating ALK alterations in the IMT areas in one of them.
|
17122505 |
2006 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Chromosomal translocations leading to activation of the ALK tyrosine kinase can be detected in approximately 50% of IMTs, particularly those arising in young patients.
|
17938159 |
2008 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
ALK probe rearrangement in a t(2;11;2)(p23;p15;q31) translocation found in a prenatal myofibroblastic fibrous lesion: toward a molecular definition of an inflammatory myofibroblastic tumor family?
|
11284039 |
2001 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
An inflammatory myofibroblastic tumor in liver with ALK and RANBP2 gene rearrangement: combination of distinct morphologic, immunohistochemical, and genetic features.
|
18701132 |
2008 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Currently, the definitive means of diagnosing IMTs is the identification of a rearrangement of the anaplastic lymphoma kinase gene (at chromosome 2p23) by fluorescence in situ hybridization.
|
22588194 |
2012 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Chromoplectic TPM3-ALK rearrangement in a patient with inflammatory myofibroblastic tumor who responded to ceritinib after progression on crizotinib.
|
27742657 |
2016 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
CLTC encodes a major subunit of clathrin, a multimeric protein on cytoplasmic organelles, and is a known recurrent fusion partner of the ALK tyrosine kinase gene in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumors.
|
12917640 |
2003 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Five CFTs were analyzed for IMT-related rearrangements in ALK, ROS1 and RET using fluorescence in situ hybridization (FISH).
|
31202195 |
2019 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Crizotinib, a dual MET/ALK inhibitor, has demonstrated promising clinical activity in patients with non-small-cell lung cancer and inflammatory myofibroblastic tumors harboring ALK translocations.
|
22034911 |
2011 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
It is known, however, that ALK gene rearrangements are common in inflammatory myofibroblastic tumors, similar to non-small cell lung cancer.
|
29925295 |
2019 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Of note, 1 tumor previously diagnosed as leiomyosarcoma was established as inflammatory myofibroblastic tumor along this study with a novel ALK-TNS1 fusion.
|
31121144 |
2019 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We report two emblematic cases of IMT in pediatric patients, treated with the second-generation ALK inhibitor ceritinib in the context of a clinical trial (NCT01742286).
|
30697903 |
2019 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
One exceptional case of a RANBP2-ALK-positive epithelioid inflammatory myofibroblastic sarcoma (an aggressive variant of IMT) showed moderate cytoplasmic staining for pan-Trk.
|
31578734 |
2019 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Of the ALK-1 immunoreactive lesions, nine lymphomas were concordantly ALK translocation-positive but one vesical inflammatory myofibroblastic tumor was discordantly FISH-negative.
|
15887977 |
2004 |
Inflammatory Myofibroblastic Tumor
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The expression of CD30 and ALK1 with ALK gene rearrangement raised the possibility of three diagnoses: a primary cutaneous anaplastic large cell lymphoma (ALCL), a cutaneous inflammatory myofibroblastic tumor (IMT), an AFH of the skin associated with ALK gene rearrangement and CD30 positivity.
|
24666231 |
2014 |