Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
HPO |
|
|
|
Cerebral Infarction
|
0.370 |
Biomarker
|
disease |
CTD_human |
|
|
|
Cerebral Infarction, Left Hemisphere
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
|
|
|
Cerebral Infarction, Right Hemisphere
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
|
|
|
Anterior Choroidal Artery Infarction
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
|
|
|
Subcortical Infarction
|
0.300 |
Biomarker
|
disease |
CTD_human |
|
|
|
Posterior Choroidal Artery Infarction
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
|
|
|
Pulmonary Hypertension
|
0.200 |
Biomarker
|
phenotype |
RGD |
Inhibition of 5-lipoxygenase-activating protein (FLAP) reduces pulmonary vascular reactivity and pulmonary hypertension in hypoxic rats.
|
8647941 |
1996 |
Rheumatoid Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The expression of arachidonate 5-lipoxygenase (5-LOX, arachidonate: oxygen 5-oxydoreductase; EC 1.13.11.34) and the 5-lipoxygenase activating protein (FLAP) genes in osteoarthritis and RA synoviocytes was studied at the transcriptional level by reverse transcription-polymerase chain reaction (RT-PCR) methodology.
|
8750209 |
1995 |
Degenerative polyarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The expression of arachidonate 5-lipoxygenase (5-LOX, arachidonate: oxygen 5-oxydoreductase; EC 1.13.11.34) and the 5-lipoxygenase activating protein (FLAP) genes in osteoarthritis and RA synoviocytes was studied at the transcriptional level by reverse transcription-polymerase chain reaction (RT-PCR) methodology.
|
8750209 |
1995 |
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These data suggest that up-regulation of 5-LO and FLAP mRNAs might be involved in the increased leukotriene synthesis and play an important role in the pathogenesis of asthma.
|
9642160 |
1998 |
Hyperoxia
|
0.200 |
Biomarker
|
phenotype |
RGD |
Hyperoxia increases protein mass of 5-lipoxygenase and its activating protein, flap, and leukotriene B(4) output in newborn rat lungs.
|
12490039 |
2002 |
Proteinuria
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Inhibition of 5-lipoxygenase activating protein decreases proteinuria in diabetic rats.
|
12649539 |
2003 |
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No ALOX5AP allele was associated with asthma or asthma-related phenotypes in case-control or TDT analyses.
|
12911785 |
2003 |
Glomerulonephritis
|
0.200 |
ModifyingMutation
|
disease |
RGD |
Increased 5-lipoxygenase activating protein in immune-mediated experimental nephritis.
|
14733414 |
2004 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We conclude that variants of ALOX5AP are involved in the pathogenesis of both myocardial infarction and stroke by increasing leukotriene production and inflammation in the arterial wall.
|
14770184 |
2004 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
LHGDN |
We conclude that variants of ALOX5AP are involved in the pathogenesis of both myocardial infarction and stroke by increasing leukotriene production and inflammation in the arterial wall.
|
14770184 |
2004 |
Myocardial Infarction
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
We conclude that variants of ALOX5AP are involved in the pathogenesis of both myocardial infarction and stroke by increasing leukotriene production and inflammation in the arterial wall.
|
14770184 |
2004 |
Myocardial Infarction
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We conclude that variants of ALOX5AP are involved in the pathogenesis of both myocardial infarction and stroke by increasing leukotriene production and inflammation in the arterial wall.
|
14770184 |
2004 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
This replication of haplotype association with stroke in a population outside Iceland further supports a role for ALOX5AP in cardiovascular diseases.
|
15640973 |
2005 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
LHGDN |
This replication of haplotype association with stroke in a population outside Iceland further supports a role for ALOX5AP in cardiovascular diseases.
|
15640973 |
2005 |
Myocardial Infarction
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We recently reported a linkage and association study of MI and stroke that yielded a genetic variant, HapA, in the gene encoding 5-lipoxygenase-activating protein (ALOX5AP), that associates with both diseases in Iceland.
|
15640973 |
2005 |
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To further assess the contribution of the ALOX5AP variants to cardiovascular diseases in a population outside Iceland, we genotyped seven single-nucleotide polymorphisms that define both HapA and HapB from 450 patients with ischemic stroke and 710 controls from Aberdeenshire, Scotland.
|
15640973 |
2005 |
Cardiovascular Diseases
|
0.040 |
Biomarker
|
group |
BEFREE |
This replication of haplotype association with stroke in a population outside Iceland further supports a role for ALOX5AP in cardiovascular diseases.
|
15640973 |
2005 |
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A nominally significant association with stroke was observed with several SNPs from ALOX5AP, including SNP SG13S114, which had been part of the Icelandic at-risk haplotype.
|
15731479 |
2005 |