Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.400 Biomarker group HPO
CUI: C0007785
Disease: Cerebral Infarction
Cerebral Infarction 		0.370 Biomarker disease CTD_human
CUI: C0751010
Disease: Cerebral Infarction, Left Hemisphere
Cerebral Infarction, Left Hemisphere 		0.300 Biomarker phenotype CTD_human
CUI: C0751011
Disease: Cerebral Infarction, Right Hemisphere
Cerebral Infarction, Right Hemisphere 		0.300 Biomarker phenotype CTD_human
CUI: C0751012
Disease: Anterior Choroidal Artery Infarction
Anterior Choroidal Artery Infarction 		0.300 Biomarker phenotype CTD_human
CUI: C0751014
Disease: Subcortical Infarction
Subcortical Infarction 		0.300 Biomarker disease CTD_human
CUI: C0887799
Disease: Posterior Choroidal Artery Infarction
Posterior Choroidal Artery Infarction 		0.300 Biomarker phenotype CTD_human
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.400 GeneticVariation group BEFREE 5-lipoxygenase activating (ALOX5AP) gene involved in the synthesis of leukotrienes, has been recognized as an important gene contributing towards susceptibility of stroke risk. 23746795 2013
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.370 Biomarker disease BEFREE Arachidonate 5-lipoxygenase activating protein (ALOX5AP) gene is involved in the pathogenesis of atherosclerotic cardiovascular disease (CVD). 16261187 2006
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.040 GeneticVariation group BEFREE ALOX5AP haplotypes that associate with CVD are not associated with obesity or insulin resistance. 16261187 2006
CUI: C0028754
Disease: Obesity
Obesity 		0.020 GeneticVariation disease BEFREE ALOX5AP haplotypes that associate with CVD are not associated with obesity or insulin resistance. 16261187 2006
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.100 Biomarker disease BEFREE Arachidonate 5-lipoxygenase activating protein (ALOX5AP) has been reported to demonstrate linkage and association with ischemic stroke and myocardial infarction. 17387518 2007
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		0.090 GeneticVariation disease BEFREE ALOX5AP gene variants and risk of coronary artery disease: an angiography-based study. 17505527 2007
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.090 GeneticVariation disease BEFREE ALOX5AP gene variants and risk of coronary artery disease: an angiography-based study. 17505527 2007
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		0.090 Biomarker disease BEFREE ALOX5AP, a gene within the inflammatory leukotriene pathway linked to and associated with coronary atherosclerosis, is also associated with in-stent restenosis. 18374923 2008
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.100 GeneticVariation disease BEFREE Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and coronary heart disease risk in familial hypercholesterolemia. 18775537 2009
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		0.090 GeneticVariation disease BEFREE Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and coronary heart disease risk in familial hypercholesterolemia. 18775537 2009
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.400 GeneticVariation group BEFREE ALOX5AP genetic variants and risk of atherothrombotic stroke in the Taiwanese population. 22051033 2011
CUI: C0004096
Disease: Asthma
Asthma 		0.100 Biomarker disease BEFREE ALOX5AP and LTA4H are associated with asthma susceptibility, suggesting a role for LTB4 in disease. 23167751 2012
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke 		0.100 GeneticVariation disease BEFREE ALOX5AP SG13S114 polymorphism is associated with susceptibility to IS in Chinese population. 24148560 2014
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.100 GeneticVariation disease BEFREE rs4769874 (ALOX5AP), rs854560 (PON1), and rs4646903 (CYP1A1 MspI polymorphism) are significantly associated with an increased risk of CAD with respective odds ratios of 1.53703, 1.67710, and 1.35520; the genetic variant rs9579646 (ALOX5AP) is significantly associated with a decreased risk of CAD (OR 0.76163). 25902778 2015
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke 		0.100 GeneticVariation disease BEFREE A first meta-analysis of both subsets showed that the T allele of the SG13S114 SNP in ALOX5AP was a risk factor for IS after Bonferroni correction [OR = 1.22 (1.06-1.40); p = 0.006]. 20357438 2010
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.100 GeneticVariation disease BEFREE A genome-wide approach found significant association of two at-risk haplotypes (HapA, HapB) in the ALOX5AP gene with myocardial infarction and stroke. 21153769 2011
CUI: C3822559
Disease: response to epirubicin
response to epirubicin 		0.100 GeneticVariation phenotype GWASCAT A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. 24025145 2013
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.090 GeneticVariation disease BEFREE A key role in the inflammatory pathway is played by the 5-lipoxygenase activating protein (ALOX5AP), which is known to influence the risk of CHD in FH. 19361804 2009