|
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
HPO |
|
|
|
|
Cerebral Infarction
|
0.370 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Cerebral Infarction, Left Hemisphere
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
|
|
|
|
Cerebral Infarction, Right Hemisphere
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
|
|
|
|
Anterior Choroidal Artery Infarction
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
|
|
|
|
Subcortical Infarction
|
0.300 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Posterior Choroidal Artery Infarction
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
|
|
|
|
Rheumatoid Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The expression of arachidonate 5-lipoxygenase (5-LOX, arachidonate: oxygen 5-oxydoreductase; EC 1.13.11.34) and the 5-lipoxygenase activating protein (FLAP) genes in osteoarthritis and RA synoviocytes was studied at the transcriptional level by reverse transcription-polymerase chain reaction (RT-PCR) methodology.
|
8750209 |
1995 |
|
Degenerative polyarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The expression of arachidonate 5-lipoxygenase (5-LOX, arachidonate: oxygen 5-oxydoreductase; EC 1.13.11.34) and the 5-lipoxygenase activating protein (FLAP) genes in osteoarthritis and RA synoviocytes was studied at the transcriptional level by reverse transcription-polymerase chain reaction (RT-PCR) methodology.
|
8750209 |
1995 |
|
Pulmonary Hypertension
|
0.200 |
Biomarker
|
phenotype |
RGD |
Inhibition of 5-lipoxygenase-activating protein (FLAP) reduces pulmonary vascular reactivity and pulmonary hypertension in hypoxic rats.
|
8647941 |
1996 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These data suggest that up-regulation of 5-LO and FLAP mRNAs might be involved in the increased leukotriene synthesis and play an important role in the pathogenesis of asthma.
|
9642160 |
1998 |
|
Hyperoxia
|
0.200 |
Biomarker
|
phenotype |
RGD |
Hyperoxia increases protein mass of 5-lipoxygenase and its activating protein, flap, and leukotriene B(4) output in newborn rat lungs.
|
12490039 |
2002 |
|
Proteinuria
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Inhibition of 5-lipoxygenase activating protein decreases proteinuria in diabetic rats.
|
12649539 |
2003 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No ALOX5AP allele was associated with asthma or asthma-related phenotypes in case-control or TDT analyses.
|
12911785 |
2003 |
|
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We conclude that variants of ALOX5AP are involved in the pathogenesis of both myocardial infarction and stroke by increasing leukotriene production and inflammation in the arterial wall.
|
14770184 |
2004 |
|
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
LHGDN |
We conclude that variants of ALOX5AP are involved in the pathogenesis of both myocardial infarction and stroke by increasing leukotriene production and inflammation in the arterial wall.
|
14770184 |
2004 |
|
Glomerulonephritis
|
0.200 |
ModifyingMutation
|
disease |
RGD |
Increased 5-lipoxygenase activating protein in immune-mediated experimental nephritis.
|
14733414 |
2004 |
|
Myocardial Infarction
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
We conclude that variants of ALOX5AP are involved in the pathogenesis of both myocardial infarction and stroke by increasing leukotriene production and inflammation in the arterial wall.
|
14770184 |
2004 |
|
Myocardial Infarction
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We conclude that variants of ALOX5AP are involved in the pathogenesis of both myocardial infarction and stroke by increasing leukotriene production and inflammation in the arterial wall.
|
14770184 |
2004 |
|
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
LHGDN |
Studies that employ genome-wide linkage scans with hundreds of small nuclear families have identified new susceptibility genes for coronary artery disease and myocardiaI infarction, including ALOX5AP (encoding 5-lipoxygenase-activating protein) associated with myocardial infarction and stroke and PDE4D (encoding phosphodiesterase 4D) for ischemic stroke.
|
15861005 |
2005 |
|
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
Studies that employ genome-wide linkage scans with hundreds of small nuclear families have identified new susceptibility genes for coronary artery disease and myocardiaI infarction, including ALOX5AP (encoding 5-lipoxygenase-activating protein) associated with myocardial infarction and stroke and PDE4D (encoding phosphodiesterase 4D) for ischemic stroke.
|
15861005 |
2005 |
|
Cerebrovascular accident
|
0.400 |
Biomarker
|
group |
BEFREE |
Four new susceptibility genes have been identified using genome-wide association studies or genome-wide linkage studies: LTA (encoding cytokine lymphotoxin-alpha) on 6p21.3 for MI; LGALS2 (encoding galectin-2, an LTA-interacting protein) on 22q12-q13 for MI; ALOX5AP (encoding 5-lipoxygenase activating protein involved in synthesizing potent pro-inflammatory leukotrienes) on 13q12-13 for MI and stroke; and PDE4D (encoding phosphodiesterase 4D) on 5q12 for ischemic stroke.
|
15811259 |
2005 |
|
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
This replication of haplotype association with stroke in a population outside Iceland further supports a role for ALOX5AP in cardiovascular diseases.
|
15640973 |
2005 |
|
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Recently, the 5-lipoxygenase activating protein gene (ALOX5AP) was reported to confer a risk of myocardial infarction (MI) and stroke, independent of conventional risk factors.
|
16127181 |
2005 |
|
Cerebrovascular accident
|
0.400 |
GeneticVariation
|
group |
LHGDN |
This replication of haplotype association with stroke in a population outside Iceland further supports a role for ALOX5AP in cardiovascular diseases.
|
15640973 |
2005 |