|
Lupus Erythematosus, Systemic
|
0.410 |
GeneticVariation
|
disease |
GWASCAT |
Transancestral mapping and genetic load in systemic lupus erythematosus.
|
28714469 |
2017 |
|
Lupus Erythematosus, Systemic
|
0.410 |
GeneticVariation
|
disease |
GWASCAT |
Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans.
|
26663301 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.410 |
GeneticVariation
|
disease |
BEFREE |
Significant associations were found for the single nucleotide polymorphism rs10036748 of TNIP1 with photosensitivity (odds ratio (OR) = 0.87, p = 0.01) and vasculitis (OR = 1.18, p = 0.04); rs10847697 of SLC15A4 with discoid rash (OR = 1.18, p = 0.02); rs6590330 of ETS1 with SLE of age at diagnosis <20 years (OR = 1.24, p = 8.91 x 10(-5)); rs13385731 of RasGRP3 with malar rash (OR = 1.20, p = 0.01), discoid rash (OR = 0.78, p = 0.02) and ANA (OR = 0.72, p = 0.004); rs4917014 of IKZF1 with renal nephritis (OR = 1.13, p = 0.02) and malar rash (OR = 0.83, p = 0.00038), respectively.
|
20516000 |
2010 |
|
Lupus Erythematosus, Systemic
|
0.410 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
|
19838193 |
2009 |
|
Lupus Erythematosus, Systemic
|
0.410 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
|
19838193 |
2009 |
|
Lupus Erythematosus, Systemic
|
0.410 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
|
19838193 |
2009 |
|
Libman-Sacks Disease
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
|
19838193 |
2009 |
|
Leukemia, Myelocytic, Acute
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.
|
27903959 |
2017 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Downregulation of RasGRP3 using small interfering (si) RNA significantly inhibited PTC cell proliferation and migration in vitro, and tumor growth in vivo, reflecting an oncogenic role of RasGRP3 in PTC.
|
28864115 |
2017 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
To observe the RasGRP3 function in tumor formation, the Severe combined immunodeficiency (SCID) mouse model was used.
|
24779681 |
2014 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
After PC-3 cells were transfected by small interfering RNA targeting RasGRP3, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and migratory assays were employed to determine the vitality and aggressive capability of tumor cell in vitro.
|
24418912 |
2014 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
RasGRP3-overexpressing LNCaP cells displayed a markedly enhanced rate of xenograft tumor formation in both male and female mice compared with the parental line.
|
20876802 |
2010 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
RasGRP3 suppression also inhibited cell invasion and migration and reduced proliferation, demonstrating the importance of RasGRP3 for the transformed phenotype of melanoma cells.
|
29461644 |
2018 |
|
Tumor Cell Invasion
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
RasGRP3 activated Ras and Rap1 in glioma cells and increased cell migration and invasion partially via Ras activation.
|
25682201 |
2015 |
|
Tumor Cell Invasion
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
These data suggested that elevated RasGRP3 expression may play a key role in the malignant progression of PCa, especially in invasion and metastasis, and may be a potential marker of biochemical recurrence.
|
24418912 |
2014 |
|
melanoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Integrative transcriptome analysis of human and murine melanomas identified RasGRP3 to be specifically expressed in GNAQ/GNA11-driven melanomas.
|
29490280 |
2018 |
|
Uveal melanoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
This implicates RasGRP3 as a critical node and a potential target in UM.
|
29490280 |
2018 |
|
Squamous cell carcinoma of esophagus
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Since RasGRP3 transcript levels have prognostic value in discriminating ESCC with different clinical aggressiveness, we decided to investigate its putative oncogenic role in ESCC.
|
29461644 |
2018 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
The findings nominate RasGRP3 as a therapeutic target for cancers driven by oncogenic GNAQ/11.
|
28486107 |
2017 |
|
Uveal melanoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma.
|
28486107 |
2017 |
|
Squamous cell carcinoma of esophagus
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, these findings provide a new insight into the upregulation of RasGRP3 involved in Notch pathway activation in the development of ESCC, especially under nutrient deprivation.
|
29048643 |
2017 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
This study was undertaken to investigate the expression of guanyl nucleotide-releasing protein for Ras 3 (RasGRP3) in the cell lines and tissues in BPH and prostate cancer (PCa), as well as its associations with cancer invasion and prognosis in prostate carcinomas.
|
24418912 |
2014 |
|
Malignant neoplasm of prostate
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In addition, human PCa cell lines PC-3, DU145, LNCaP, PC3M-1E8, PC3M-2B4 and BPH-1 were examined for expression of RasGRP3 using western blot and quantitative polymerase chain reaction (Q-PCR) analysis.
|
24418912 |
2014 |
|
Prostate carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In addition, human PCa cell lines PC-3, DU145, LNCaP, PC3M-1E8, PC3M-2B4 and BPH-1 were examined for expression of RasGRP3 using western blot and quantitative polymerase chain reaction (Q-PCR) analysis.
|
24418912 |
2014 |