GC, GC vitamin D binding protein, 2638

N. diseases: 219; N. variants: 17
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.370 GeneticVariation disease BEFREE We found no clear association between MS and frequencies of phenotypes or alleles of Gc protein. 3218452 1988
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.370 GeneticVariation disease BEFREE In conclusion, our findings do not support a role of an independent effect of the investigated vitamin D-related gene variants, VDBP and CYP27B1, in the risk of MS. 27904983 2017
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.370 GeneticVariation disease BEFREE Vitamin D-Binding Protein Polymorphisms, 25-Hydroxyvitamin D, Sunshine and Multiple Sclerosis. 29414925 2018
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.350 GeneticVariation disease BEFREE The proteomic approach detected significantly decreased expression of vitamin D-binding protein (VDBP) in the synovial membranes from patients with RA, which was confirmed with western blot analysis. rs2282679 was significantly associated with RA and AS (p=0.026794 and 0.007566, respectively). 22704802 2012
CUI: C0162557
Disease: Liver Failure, Acute
Liver Failure, Acute 		0.330 GeneticVariation disease BEFREE In a retrospective analysis of the double-blind trial of intravenous N-acetylcysteine (NAC) for ALF not because of acetaminophen, sera on days 1 and 3 or days 2 and 4 following admission were available to measure AFP in 70 patients and Gc in 66 patients. 31421008 2019
CUI: C0018213
Disease: Graves Disease
Graves Disease 		0.320 GeneticVariation disease BEFREE A polymorphism within the vitamin D-binding protein gene is associated with Graves' disease but not with Hashimoto's thyroiditis. 12050214 2002
CUI: C0018213
Disease: Graves Disease
Graves Disease 		0.320 GeneticVariation disease BEFREE In conclusion, genetic differences in the VDR gene may be involved in the development of AITD and the activity of GD, whereas the genetic differences in the GC and CYP2R1 genes may be involved with the intractability of GD. 25046415 2014
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.310 GeneticVariation disease BEFREE Interestingly, WT- diplotype (less than 3 VDBP major alleles) was associated with significant liver fibrosis (p = 0.045). 31600151 2017
CUI: C0042870
Disease: Vitamin D Deficiency
Vitamin D Deficiency 		0.200 GeneticVariation disease BEFREE In women with a vitamin D deficiency (<20 ng/ml), the GT allele of the VDBP SNP rs7041 (p value =0.04), the VDBP allelic combination Gc1F/1F (T allele of rs4588 and C allele of rs7041) (p value =0.03), and the GA allele of the CYP2R1 SNP rs2060793 (p = 0.05) were associated with an increased risk of developing PCOS. 28008453 2018
CUI: C0042870
Disease: Vitamin D Deficiency
Vitamin D Deficiency 		0.200 GeneticVariation disease GWASDB Common genetic determinants of vitamin D insufficiency: a genome-wide association study. 20541252 2010
CUI: C0042870
Disease: Vitamin D Deficiency
Vitamin D Deficiency 		0.200 GeneticVariation disease BEFREE Prevalence of vitamin D deficiency in women from southern Brazil and association with vitamin D-binding protein levels and GC-DBP gene polymorphisms. 31830090 2019
CUI: C0042870
Disease: Vitamin D Deficiency
Vitamin D Deficiency 		0.200 GeneticVariation disease BEFREE The rs70141657G/A of CYP2R1 and rs7041T/G and rs4588C/A of vitamin D binding protein genetic polymorphisms were associated with increased risk of vitamin D deficiency among apparently healthy Jordanians. 26383826 2015
CUI: C0042870
Disease: Vitamin D Deficiency
Vitamin D Deficiency 		0.200 GeneticVariation disease BEFREE Hypovitaminosis D in a Young Lebanese Population: Effect of GC Gene Polymorphisms on Vitamin D and Vitamin D Binding Protein Levels. 26404398 2015
CUI: C0042870
Disease: Vitamin D Deficiency
Vitamin D Deficiency 		0.200 GeneticVariation disease BEFREE Our findings for the first time indicated that there is a strong association between vitamin D deficiency, lipid profile and the VDR rs1544410G>A and rs7T41>G VDBP genes polymorphisms. 31359379 2019
CUI: C0042870
Disease: Vitamin D Deficiency
Vitamin D Deficiency 		0.200 GeneticVariation disease BEFREE Vitamin D deficiency is frequently present in chronic liver disease and may predict non-response to antiviral therapy in chronic hepatitis C. Small studies suggest that vitamin D supplementation improves sustained viral response rates, while 1α-hydroxylase polymorphisms and vitamin D-binding protein are also implicated in therapeutic outcomes. 22634121 2012
CUI: C0042870
Disease: Vitamin D Deficiency
Vitamin D Deficiency 		0.200 GeneticVariation disease GWASCAT Common genetic determinants of vitamin D insufficiency: a genome-wide association study. 20541252 2010
CUI: C0042870
Disease: Vitamin D Deficiency
Vitamin D Deficiency 		0.200 GeneticVariation disease BEFREE Using multiple logistic regression analysis, vitamin D deficiency was significantly associated with the GC rs2282679 genotype (odds ratio [OR] per C allele 1.80, 95% confidence interval CI 1.57-2.01), independent of established risk factors for vitamin D deficiency including age, sex, and BMI. 25370324 2015
CUI: C0023508
Disease: White Blood Cell Count procedure
White Blood Cell Count procedure 		0.100 GeneticVariation phenotype GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
CUI: C0023508
Disease: White Blood Cell Count procedure
White Blood Cell Count procedure 		0.100 GeneticVariation phenotype GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.100 GeneticVariation disease LHGDN Risk and severity of COPD is associated with the group-specific component of serum globulin 1F allele. 14718422 2004
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.100 GeneticVariation disease BEFREE 471 PiZZ subjects with α1-antitrypsin deficiency (AATD) were genotyped for tag single nucleotide polymorphisms (SNPs) covering the DBP gene (GC), together with known functional variants, prior to seeking association with COPD phenotypes. 21228423 2011
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.100 GeneticVariation disease BEFREE Dual role of vitamin D-binding protein 1F allele in chronic obstructive pulmonary disease susceptibility: a meta-analysis. 25966120 2015
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.100 GeneticVariation disease BEFREE Systematic Review and Meta-Analysis to Establish the Association of Common Genetic Variations in Vitamin D Binding Protein With Chronic Obstructive Pulmonary Disease. 31156695 2019
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.100 GeneticVariation disease BEFREE Through four databases, two independent investigators searched for case-control studies providing sufficient data to calculate odds ratios by the vitamin D binding protein allele variant and genotype variant for a case of COPD. 25488093 2015
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.100 GeneticVariation disease BEFREE Several reports have described associations between GC haplotypes and COPD but these remain controversial. 12947140 2003