GC, GC vitamin D binding protein, 2638

N. diseases: 219; N. variants: 17
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2282679
rs2282679
Entrez Id: 2638
Gene Symbol: GC
GC
CUI: C0042870
Disease:
Vitamin D Deficiency 		0.810 GeneticVariation BEFREE Using multiple logistic regression analysis, vitamin D deficiency was significantly associated with the GC rs2282679 genotype (odds ratio [OR] per C allele 1.80, 95% confidence interval CI 1.57-2.01), independent of established risk factors for vitamin D deficiency including age, sex, and BMI. 25370324 2015
dbSNP: rs2282679
rs2282679
Entrez Id: 2638
Gene Symbol: GC
GC
CUI: C0042870
Disease:
Vitamin D Deficiency 		0.810 GeneticVariation GWASCAT Common genetic determinants of vitamin D insufficiency: a genome-wide association study. 20541252 2010
dbSNP: rs2282679
rs2282679
Entrez Id: 2638
Gene Symbol: GC
GC
CUI: C0042870
Disease:
Vitamin D Deficiency 		0.810 GeneticVariation GWASDB Common genetic determinants of vitamin D insufficiency: a genome-wide association study. 20541252 2010
dbSNP: rs2282679
rs2282679
Entrez Id: 2638
Gene Symbol: GC
GC
CUI: C0919758
Disease:
Vitamin D measurement 		T 0.800 GeneticVariation GWASCAT Transethnic Evaluation Identifies Low-Frequency Loci Associated With 25-Hydroxyvitamin D Concentrations. 29325163 2018
dbSNP: rs2282679
rs2282679
Entrez Id: 2638
Gene Symbol: GC
GC
CUI: C0523979
Disease:
Vitamin D3 measurement 		T 0.800 GeneticVariation GWASCAT Transethnic Evaluation Identifies Low-Frequency Loci Associated With 25-Hydroxyvitamin D Concentrations. 29325163 2018
dbSNP: rs2282679
rs2282679
Entrez Id: 2638
Gene Symbol: GC
GC
CUI: C0919758
Disease:
Vitamin D measurement 		T 0.800 GeneticVariation GWASCAT Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels. 29343764 2018
dbSNP: rs2282679
rs2282679
Entrez Id: 2638
Gene Symbol: GC
GC
CUI: C0523979
Disease:
Vitamin D3 measurement 		T 0.800 GeneticVariation GWASCAT Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels. 29343764 2018
dbSNP: rs2282679
rs2282679
Entrez Id: 2638
Gene Symbol: GC
GC
CUI: C0523979
Disease:
Vitamin D3 measurement 		0.800 GeneticVariation GWASCAT Genome-wide association analysis of circulating vitamin D levels in children with asthma. 22673963 2012
dbSNP: rs2282679
rs2282679
Entrez Id: 2638
Gene Symbol: GC
GC
CUI: C0523979
Disease:
Vitamin D3 measurement 		0.800 GeneticVariation GWASDB Genome-wide association analysis of circulating vitamin D levels in children with asthma. 22673963 2012
dbSNP: rs2282679
rs2282679
Entrez Id: 2638
Gene Symbol: GC
GC
CUI: C0919758
Disease:
Vitamin D measurement 		0.800 GeneticVariation GWASCAT Genome-wide association analysis of circulating vitamin D levels in children with asthma. 22673963 2012
dbSNP: rs2282679
rs2282679
Entrez Id: 2638
Gene Symbol: GC
GC
CUI: C0919758
Disease:
Vitamin D measurement 		0.800 GeneticVariation GWASDB Genome-wide association analysis of circulating vitamin D levels in children with asthma. 22673963 2012
dbSNP: rs2282679
rs2282679
Entrez Id: 2638
Gene Symbol: GC
GC
CUI: C0919758
Disease:
Vitamin D measurement 		C 0.800 GeneticVariation GWASDB Genome-wide association study of circulating vitamin D levels. 20418485 2010
dbSNP: rs2282679
rs2282679
Entrez Id: 2638
Gene Symbol: GC
GC
CUI: C0523979
Disease:
Vitamin D3 measurement 		C 0.800 GeneticVariation GWASCAT Genome-wide association study of circulating vitamin D levels. 20418485 2010
dbSNP: rs2282679
rs2282679
Entrez Id: 2638
Gene Symbol: GC
GC
CUI: C0523979
Disease:
Vitamin D3 measurement 		C 0.800 GeneticVariation GWASDB Genome-wide association study of circulating vitamin D levels. 20418485 2010
dbSNP: rs2282679
rs2282679
Entrez Id: 2638
Gene Symbol: GC
GC
CUI: C0919758
Disease:
Vitamin D measurement 		C 0.800 GeneticVariation GWASCAT Genome-wide association study of circulating vitamin D levels. 20418485 2010
dbSNP: rs3755967
rs3755967
Entrez Id: 2638
Gene Symbol: GC
GC
CUI: C0023508
Disease:
White Blood Cell Count procedure 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs3755967
rs3755967
Entrez Id: 2638
Gene Symbol: GC
GC
CUI: C0523979
Disease:
Vitamin D3 measurement 		T 0.700 GeneticVariation GWASCAT Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels. 29343764 2018
dbSNP: rs3755967
rs3755967
Entrez Id: 2638
Gene Symbol: GC
GC
CUI: C0919758
Disease:
Vitamin D measurement 		T 0.700 GeneticVariation GWASCAT Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels. 29343764 2018
dbSNP: rs4588
rs4588
Entrez Id: 2638
Gene Symbol: GC
GC
CUI: C0523979
Disease:
Vitamin D3 measurement 		A 0.700 GeneticVariation GWASCAT Genome-Wide Association Study of Serum 25-Hydroxyvitamin D in US Women. 29545823 2018
dbSNP: rs4588
rs4588
Entrez Id: 2638
Gene Symbol: GC
GC
CUI: C0919758
Disease:
Vitamin D measurement 		A 0.700 GeneticVariation GWASCAT These were located in or near <i>GC</i>, the vitamin D binding protein, or <i>CYP2R1</i>, a cytochrome P450 enzyme that hydroxylates vitamin D to form 25(OH)D. The top hit was rs4588, a missense <i>GC</i> polymorphism associated with a 3.5 ng/mL decrease in 25(OH)D per copy of the minor allele (95% confidence interval [CI]: -4.1, -3.0; <i>p</i> = 4.5 × 10<sup>-38</sup>). 29545823 2018
dbSNP: rs7041
rs7041
Entrez Id: 2638
Gene Symbol: GC
GC
CUI: C0523979
Disease:
Vitamin D3 measurement 		C 0.700 GeneticVariation GWASCAT Transethnic Evaluation Identifies Low-Frequency Loci Associated With 25-Hydroxyvitamin D Concentrations. 29325163 2018
dbSNP: rs7041
rs7041
Entrez Id: 2638
Gene Symbol: GC
GC
CUI: C0919758
Disease:
Vitamin D measurement 		C 0.700 GeneticVariation GWASCAT Transethnic Evaluation Identifies Low-Frequency Loci Associated With 25-Hydroxyvitamin D Concentrations. 29325163 2018
dbSNP: rs7041
rs7041
Entrez Id: 2638
Gene Symbol: GC
GC
CUI: C2985280
Disease:
Blood Protein Measurement 		C 0.700 GeneticVariation GWASCAT Genomic atlas of the human plasma proteome. 29875488 2018
dbSNP: rs843005
rs843005
Entrez Id: 2638
Gene Symbol: GC
GC
CUI: C0919758
Disease:
Vitamin D measurement 		T 0.700 GeneticVariation GWASCAT Transethnic Evaluation Identifies Low-Frequency Loci Associated With 25-Hydroxyvitamin D Concentrations. 29325163 2018
dbSNP: rs843005
rs843005
Entrez Id: 2638
Gene Symbol: GC
GC
CUI: C0523979
Disease:
Vitamin D3 measurement 		T 0.700 GeneticVariation GWASCAT Transethnic Evaluation Identifies Low-Frequency Loci Associated With 25-Hydroxyvitamin D Concentrations. 29325163 2018